Chinese Journal of Stroke

China Stroke Statistics 2020 (1)

WANG Yongjun, LI Zixiao, GU Hongqiu, ZHAI Yi, JIANG Yong, ZHOU Qi, ZHAO Xingquan, WANG Yilong, YANG Xin, WANG Chunjuan, MENG Xia, LI Hao, LIU Liping, JING Jing, WU Jing, XU Anding, DONG Qiang, David Wang, WANG Wenzhi, MA Xudong, ZHAO Jizong, China Stroke Statistics Writing Committee

2022, 17(05): 433-447. DOI: 10.3969/j.issn.1673-5765.2022.05.001

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Progress of Headache due to Reversible Cerebral Vasoconstriction Syndrome

LIU Yonghui, YANG Kan, QIN Fubin, CHEN Wenwen, HE Tingting, HUANG Yadi

2022, 17(05): 455-460. DOI: 10.3969/j.issn.1673-5765.2022.05.003

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Reversible cerebral vasoconstriction syndrome (RCVS) is a kind of cerebrovascular disease. Headache due to RCVS is relatively common in RCVS patients, and the pathogenesis is not yet clear. In this paper, headache due to RCVS may be related to vascular dystonia and endothelial dysfunction, and early identification of the disease on the basis of clinical manifestations and differential diagnosis is conductive to the prognosis of the disease.

Headache Phenotypes and Possible Mechanisms of Dural Arteriovenous Fistula

LU Jiajie, ZHAO Hongru

2022, 17(05): 461-465. DOI: 10.3969/j.issn.1673-5765.2022.05.004

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Dural arteriovenous fistula is an intracranial vascular malformation, typified by abnormal communication between meningeal arteries and dural venous sinuses or cortical veins. Headache is a common symptom with various clinical phenotypes, which makes the diagnosis more difficult. It can be manifested as migraine-like headache or non-migraine-like headache, often accompanied by pulsing tinnitus or ophthalmoplegia. At present, DSA is still the gold standard for diagnosis and characterization of dural arteriovenous fistula. Conservative treatment and endovascular embolization to reduce the shunt of dural arteriovenous fistula can effectively relieve headache symptoms. This article aimed to review the headache phenotypes, possible mechanisms and treatment outcomes of dural arteriovenous fistulas.

Central Nervous System Vasculitis and Headache

DING Man, XIAO Zheman

2022, 17(05): 466-471. DOI: 10.3969/j.issn.1673-5765.2022.05.005

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Vasculitis involving the central nervous system (CNS) is widely referred to CNS vasculitis. Headache is one of the non-specific manifestations of CNS vasculitis, and it is also the most common neurological symptom. At present, according to the 2012 Chapel Hill consensus conference (CHCC) vasculitis classification criteria, vasculitis is classified according to the size of the involved blood vessels. The pathogenesis of headaches caused by vasculitis is unknown. The destruction of the blood-brain barrier and neurovascular units may play an essential role in vasculitis-related headaches. The incidence of different types of vasculitis involving the CNS, as well as the timing and characteristics of headaches are different. It is crucial to recognize vasculitisrelated headaches and make a quick diagnosis so as to avoid unnecessary treatment or leading to severe neurological sequelae.

Progress of Headache Attributed to Unruptured Intracranial Saccular Aneurysm

DENG Ziru, SUN Wen, CHEN Yuhua, LYU Xinyi, GUI Wei

2022, 17(05): 472-476. DOI: 10.3969/j.issn.1673-5765.2022.05.006

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Rupture of intracranial saccular aneurysm is the main cause of spontaneous subarachnoid hemorrhage (SAH). Recognizing the characteristics of headache due to the unruptured intracranial saccular aneurysm (UISA) is of important clinical value to prevent the occurrence of hemorrhagic events. The mechanism of headache due to UISA is still unclear, which is now believed to be related to the dilation, compression of aneurysm, stripping of vessel wall, artery pulsation and microbleeding. And inflammatory is also involved in the process. The characteristics of headache are not specific, and migraine-like headache is the main type. For new-onset, severe, persistent headache, and headache nature changing frequently, it should be alert to the possibility of aneurysm rupture. SWI is helpful to identify high-risk headache. Simple coiling is preferred for treatment of headache due to UISA, but large sample studies are still needed.

Headache Characteristics of Carotid Artery Dissection

CHEN Meijiao, JIN Haidi, LIU Kaiming

2022, 17(05): 477-482. DOI: 10.3969/j.issn.1673-5765.2022.05.007

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Objective To investigate the headache characteristics of patients with cervical artery dissection (CAD), to provide reference for clinical diagnosis and treatment of CAD.

Methods The clinical data of patients with CAD admitted to the Second Affiliated Hospital of Zhejiang University School of Medicine and the First Affiliated Hospital of Zhejiang Chinese Medical University between September 2016 and September 2021 were retrospectively analyzed. Selecting the CAD-related headache patients, the headache characteristics (location, nature, intensity, duration, complications, etc.) of these patients were analyzed.

Results A total of 78 patients with CAD were included, including 9 patients of CAD-related headache. Among the 9 patients, there were 6 males and 3 females, aged from 16 to 70 years, with the median age of 52 years old. The dissection was located in internal carotid artery in all 9 patients, and the headache was mainly located in the eyes and frontotemporal region ipsilateral to the dissection (9 cases).No vertebral artery dissection was found. For the nature of pain, 5 patients presented with dull and distending pain, 3 with throbbing pain, and 1 with stabbing pain. Of the 9 patients, 1 presented with mild headache, 6 with moderate headache, and 2 with severe headache. 6 patients had continuous headache, and the other 3 had intermittent headache. 2 patients had a prior history of headache, and 5 patients had acute ischemic stroke or transient ischemic attack. 5 patients presented with Horner syndrome. 5 patients had vascular risk factors or carotid artery injury factors.

Conclusions CAD-related headache was more common in internal carotid artery dissection. Patients with CAD-related headache often had vascular risk factors or history of cervical artery injury. CAD-related headache was mainly located in the eyes and frontotemporal region ipsilateral to the dissection, and often accompanied by Horner syndrome. The headache was mostly moderatesevere, and the nature and duration of headache were not specific.

Correlation between Stress Hyperglycemia Ratio and Clinical Prognosis of Patients with Acute Ischemic Stroke

ZHANG Dong, LI Zhizhang, MA Ruinan, YUE Yunhua

2022, 17(05): 483-490. DOI: 10.3969/j.issn.1673-5765.2022.05.008

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Objective To investigate the correlation between stress hyperglycemia ratio (SHR) and 90-day clinical prognosis of patients with acute ischemic stroke (AIS). Methods The data of AIS patients who were admitted in Department of Neurology, Yangpu Hospital, Tongji University from May 2016 to October 2020 were retrospectively analyzed. The outcome was assessed by 90-day mRS and composite vascular events (recurrent stroke, myocardial infarction and vascular death). The favorable prognosis was defined as a mRS score of 0-2, and unfavorable prognosis was defined as a mRS score of 3-6 and composite vascular events within 90 days after stroke. SHR was calculated by fasting blood glucose divided by the estimated average blood glucose. The multivariate logistic regression analysis was used to determine whether SHR was an independent influencing factor of the 90-day prognosis. ROC curve was used to evaluate the effect of SHR to predict 90-day prognosis. Spearman correlation was used to analyze the correlation between SHR and clinical factors. Results (1) A total of 1484 patients were included,with the median age of 70 (62-80) years and 948 males (63.9%). The median baseline NIHSS score was 3 (2-7). There were 923 cases (62.2%) in favorable prognosis group and 561 cases (37.8%) in unfavorable prognosis group. (2) Univariate analysis showed that the SHR in favorable prognosis group was significantly lower than that in unfavorable prognosis group [0.82 (0.72-0.95) vs . 0.86 (0.74-1.02), P =0.001]. (3) Multivariate logistic regression analysis showed that compared with the lowest quartile of SHR, the highest quartile was independently associated with the 90-day unfavorable prognosis (OR 2.22, 95%CI 1.26-3.91, P =0.006), which had statistical difference in non-diabetic group in subgroup analysis (OR 2.11, 95%CI 1.19-3.75, P =0.010), and no statistical difference in diabetic group (OR 1.53, 95%CI 0.69-3.42, P =0.298). (4) The area under the ROC curve (C-value) of SHR for predicting 90-day unfavorable prognosis was 0.552 (95%CI 0.526-0.578, P =0.001, the optimal cut-off value was 0.84, the sensitivity was 52.94%, and the specificity was 56.12%); and in non-diabetic subgroup, the C-value was 0.600 (95%CI 0.563-0.637, P <0.001, the optimal cut-off value was 0.87, the sensitivity was 52.48%, and the specificity was 64.97%). (5) Correlation analysis showed that SHR was positively correlated with the baseline NIHSS score (r =0.115, P <0.001), CRP (r =0.079, P =0.002), and white blood cell count (r =0.126, P <0.001), while negatively correlated with platelet count (r =-0.094, P <0.001). Conclusions In AIS patients, elevated SHR was associated with unfavorable functional outcome at 90 days, especially in non-diabetic patients. SHR may be correlated with stroke severity at admission and inflammation.

The Effect of Exercise Intervention on Metabolic Indexes in Patients with Metabolic Abnormality

ZOU Xu, GU Rongna, ZHANG Han

2022, 17(05): 491-496. DOI: 10.3969/j.issn.1673-5765.2022.05.009

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Objective To evaluate the effect of exercise intervention on metabolic indexes of patients with metabolic abnormality, and explore the clinical value of non-drug intervention to prevent cardiocerebrovascular diseases. Methods This prospective study recruited the patients with metabolic abnormality at one time. According to medical examination results and physical fitness test, every patient was offered personalized exercise prescription. A total of 12-week exercise intervention was conducted through combining Wechat group management with on-site exercise guidance, with the exercise form of combining with aerobic exercise and strength training. The subjects’ metabolic indexes such as BMI, body mass, waist circumference, blood pressure, fasting blood glucose, and blood lipid were compared before and after the intervention. Metabolic syndrome severity score (MSSS) and visceral adiposity index (VAI) were calculated and compared before and after the intervention. Results A total of 109 patients were included, of whom 107 patients completed the whole-course intervention, including 43 males (40.2%) and 64 females (59.8%), with an average age of 42.6±9.3 years. After exercise intervention, metabolic indexes such as fasting blood glucose [5.1 (4.7-5.5) mmol/L vs . 5.4 (5.0-6.0) mmol/L, P <0.01], LDL-C [2.8 (2.4-3.6) mmol/L vs . 3.2 (2.7-3.7) mmol/L, P =0.04], TC [4.8 (4.3-5.4) mmol/L vs . 5.6 (4.6-5.8) mmol/L, P =0.01], TG [1.3 (0.9-1.7) mmol/L vs . 1.5 (1.1-2.3) mmol/L, P <0.01] decreased significantly. MSSS [-1.8 (-3.6-0.1) vs . -0.4 (-2.7-1.5), P <0.01] and VAI [1.4 (1.0-2.1) vs . 1.8 (1.2-3.0), P <0.01] after exercise intervention were also decreased significantly compared to that before exercise intervention. Conclusions Making personalized exercise prescription and urging patients to implement the exercise intervention through on-site and network guidance, can be a kind of effective treatment means of improving metabolic abnormality.

Analysis of Non-linguistic Cognitive Impairment in Acute Stroke Patients with Broca's Aphasia

YUAN Zinan, LIU Xinxin, YU Ping, ZHANG Yumei

2022, 17(05): 497-502. DOI: 10.3969/j.issn.1673-5765.2022.05.010

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Objective To explore the characteristics of non-linguistic cognitive impairment in acute stroke patients with Broca's aphasia, and the relationship between language impairment and non-linguistic cognitive impairment.

Methods This study prospectively enrolled acute stroke patients with Broca's aphasia and nonaphasia who were hospitalized in Department of Neurology of Beijing Tiantan Hospital, Capital Medical University from April 2019 to April 2021. The western aphasia battery (WAB) was used to assess language impairment and the second edition of Loewenstein occupational therapy cognitive assessment (LOTCA) was used to assess non-linguistic cognitive function. The LOTCA scores of Broca's aphasia and non-aphasia groups were compared. Partial correlation analysis was carried out on the sub-items of WAB with each cognitive sub-item and total score of LOTCA in Broca's aphasia group. The multivariate stepwise linear regression model was used to analyze the influence of WAB sub-items on the total score of LOTCA, to construct the regression equation according to the results. The goodness-of-fit test and significance test were performed on the regression equation. Results A total of 21 patients with Broca's aphasia and 14 patients with non-aphasia were enrolled in this study. The total LOTCA score (P <0.001) and scores of orientation (P <0.001), visual perception (P <0.001), spatial perception (P =0.007), motor praxis (P =0.006), visuomotor organization (P <0.001), thinking operation (P <0.001), and attention (P =0.010) in Broca's aphasia group were lower than those in non-aphasia group. Partial correlation regression analysis showed that the total LOTCA score was positively correlated with aphasia quotient (r =0.645, P =0.002), spontaneous speech (r =0.518, P =0.016) and comprehension (r =0.716, P <0.001) in WAB. Multivariate linear regression analysis showed that spontaneous speech and comprehension scores in WAB were the main influencing factors of the total score of LOTCA. The regression equation as follows: LOTCA total score=0.442×spontaneous speech+0.643×comprehension. The result of the goodness-of-fit and significance test showed the adjusted R 2 value was 0.682, and F =22.434, P <0.001.

Conclusions Acute stroke patients with Broca's aphasia have impairment in orientation, visual perception, spatial perception, motor praxis, visuomotor organization, thinking operation, and attention. Spontaneous speech and comprehension in language test are independent influencing factors of non-linguistic cognitive function.

Meta-analysis of Clinical Outcomes of Treatment for Anterior Circulation Tandem Lesions

ZHANG Tong, WANG Anxin, AN Yuan, ZHANG Yaqing, LIU Yanfang, ZHAO Xingquan

2022, 17(05): 503-509. DOI: 10.3969/j.issn.1673-5765.2022.05.011

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Objective To compare the differences in clinical outcomes of different treatments for anterior circulation tandem lesions. Methods Databases including PubMed, Cochrane Library, ScienceDirect, CNKI, VIP, and Wanfang were retrieved from inception to December 11, 2021 to search for the literatures involving interventional treatment for anterior circulation tandem lesions in patients with acute ischemic stroke. The patients were divided into the intervention group and control group. Treatment strategy in intervention group was simultaneous emergency interventional treatment of both lesions, including thrombectomy or thrombolysis combined with stenting, and treatment strategy in control group was first interventional treatment of the responsible lesion, including thrombectomy or thrombolysis combined with stenting, and then selective treatment of the other lesion. The clinical outcomes including technical recanalization (TICI≥2b) rate, 90-day good prognosis (mRS score of 0-2), and mortality rate were compared between the two groups. The literature quality was evaluated according to Cochrane systematic evaluation principles, and then meta-analysis was performed using R version 4.1.2. When ≥5 studies were included, funnel plots were drawn to identify publication bias and asymmetry test were performed. Results A total of 6 literatures were included in the final analysis, involving 779 patients with 584 in intervention group and 195 in control group. Meta-analysis results showed that there were statistical differences in technical success rate (OR 2.14, 95%CI 1.68-2.74, P =0.002), 90-day good prognosis rate (OR 1.46, 95%CI 1.20-1.76, P =0.049), and mortality rate (OR 0.60, 95%CI 0.47-0.76, P =0.035) between the intervention and control groups. The funnel plot was symmetrical from left to right, indicating that there was no significant publication bias for the included literatures. Conclusions In patients with anterior circulation tandem lesions, simultaneous emergency interventional treatment of both lesions is prone to higher recanalization rate, better 90-day clinical prognosis and lower mortality rate.

Efficacy of Sertraline Hydrochloride for Post-stroke Depression: A Multicenter Study

SHEN Rong, ZHOU Hua, ZHAO Zhong

2022, 17(05): 510-515. DOI: 10.3969/j.issn.1673-5765.2022.05.012

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Objective To investigate the effect of early application of sertraline on post-stroke depression (PSD) and cognitive dysfunction after ischemic stroke. Methods Patients with first acute ischemic stroke who were hospitalized in neurology department of 6 hospitals in Suzhou from February 2016 to August 2017 were randomly divided into 3 groups: the control group was given conventional treatment, the low-dose treatment group was given sertraline hydrochloride 50 mg/d on the basis of conventional treatment, and the high-dose treatment group was given sertraline hydrochloride 100 mg/d on the basis of conventional treatment, with the treatment course for 3 months. At 1 month, 3 months, 6 months and 1 year after stroke, the patients were evaluated by Hamilton depression scale (HAMD), MMSE and mRS. The incidence of PSD, cognitive function and prognosis at the above point-in-time and ischemic stroke recurrence within one year were compared among the 3 groups. Results A total of 404 patients were included in the final analysis, including 136 in control group,

140 in the low-dose treatment group, and 128 in the high-dose treatment group. (1) There were

no statistical difference in the incidence of 1-year ischemic stroke among the 3 groups; (2) The incidence of PSD in the low-dose (22.9% vs . 44.1%, P <0.001) and high-dose treatment groups (18.8% vs . 44.1%, P <0.001) were lower than that in the control group at 3 months, and the incidence of PSD in the low-dose (5.7% vs . 44.1%, P <0.001) and high-dose treatment groups (4.7% vs . 44.1%, P <0.001) were lower than that in the control group at 6 months,all with statistical differences; (3) The HAMD scores of the low-dose and high-dose treatment groups were lower than those of the control group at 3, 6 months and 1 year, all with statistical differences; (4) The MMSE score of the high-dose treatment group was higher than that of the control group at 3 months, and the MMSE scores of the low-dose and the high-dose treatment groups were higher than that of the control group at 6 and 12 months, all with statistical differences. Conclusions Early application of sertraline hydrochloride after acute ischemic stroke can reduce the incidence of post-stroke depression, improve cognitive function of patients at 1 year after stroke, while had no influence on recurrent stroke and functional prognosis.

Effect of Cognitive Reserve on the Integrity of White Matter Tracts in Patients with White Matter Hyperintensities at Different Cognitive Stage

ZHU Huahong, YE Qing, QIN Ruomeng, HUANG Lili, XU Yun

2022, 17(05): 516-522. DOI: 10.3969/j.issn.1673-5765.2022.05.013

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Objective To investigate the effect of cognitive reserve (CR) on the integrity of white matter tracts in patients with white matter hyperintensities (WMH) across different cognitive stages. Methods This study prospectively enrolled the consecutive patients with WMH who were admitted in Department of Neurology, Nanjing Drum Tower Hospital from January 2017 to December 2020. All subjects underwent neuropsychological tests, cognitive reserve assessment and multimodal MRI scans. According to the MoCA score, the patients were divided into WMH with cognitive impairment (CI) group (WMH-CI) and WMH without CI group (WMH-nonCI). According to the median cognitive reserve index (CRI), the patients were further divided into WMH-CI high CR group, WMH-CI low CR group, WMH-nonCI high CR group and WMH-nonCI low CR group. The integrity of white matter tracts was measured by the fractional anisotropy (FA), a diffusion parameter of white matter tracts, which was calculated by PANDA software. The two-factor ANOVA was used to analyze the effects of cognitive status and CR level on cognitive function, brain volume and FA value of white matter tracts, and the correlation analysis of cognitive function, brain volume and FA value was performed. Results A total of 137 patients with WMH were included, including 39 subjects with WMHnonCI and low CR, 42 with WMH-nonCI and high CR, 35 with WMH-CI and low CR, and 21 with WMH-CI and high CR. The scores of MMSE (F =5.872, P =0.017), MoCA (F =19.310, P <0.001), executive function (F =4.329, P =0.039) and processing speed (F =15.136, P <0.001) in patients with high CR were significantly higher than those in patients with low CR. Cognitive status and CR level had an interactive effect in the FA in the left uncinate tract (F =4.324, P =0.040). For patients without CI, there was no statistical difference in FA value between the low CR group and high CR group (t =−0.138, P =0.891); while for patients with CI, the FA in high CR group was significantly lower than that in low CR group (t =2.999, P =0.004). Cognitive status and CR level had an interaction effect in gray matter volume (F =4.949, P =0.028). In addition, both the FA in the left uncinate tract (r =0.368, P =0.003) and gray matter volume (r =0.292, P =0.020) were significantly positively correlated with MoCA in patients with high CR. Conclusions In patients with WMH and normal cognitive function, there was no correlation between CR level and the integrity of white matter tracts. Whereas for patients with WMH and CI, the integrity of white matter tracts was significantly decreased in those with high CR and correlated with cognitive function.

Clinical Prediction Model and Influencing Factors of Total Cerebral Small Vessel Disease Burden

MA Jiali, WANG Yuqing, WANG Kaiwen, DONG Jingjing, LI Yongqiu

2022, 17(05): 523-528. DOI: 10.3969/j.issn.1673-5765.2022.05.014

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Objective To analyze the influencing factors of total cerebral small vessel disease (CSVD) burden, and establish clinical prediction models of total CSVD burden. Methods The data of CSVD patients who were admitted in Department of Neurology of Tangshan Gongren Hospital and underwent MRI scan from January 2020 to June 2021 were retrospectively analyzed. According to the total CSVD burden based on MRI, the subjects were divided into five groups: 0, 1, 2, 3 and 4 score groups. Multivariate logistic regression analysis was used to determine the independent influencing factors of total CSVD burden, to construct the clinical prediction model. Results A total of 812 cases were included in the analysis. Multivariate logistic regression analysis showed that aging (OR 1.068, 95%CI 1.054-1.082), hypertension (OR 2.056, 95%CI 1.533-2.721), new-onset acute stroke (OR 2.303, 95%CI 1.696-3.016), previous stroke (OR 3.251, 95%CI 2.377-4.233) were independent risk factors of total CSVD burden. The prediction model of different total CSVD burden as follows: Ln (total CSVD burden ≤n )=C-(0.066×age+0.721×hypertension+0.816×acute stroke+1.155×previous stroke), and when n is 0, 1, 2 and 3, the corresponding C value is 1.028, 2.887,4.866 and 6.321, respectively. The goodness of fit of Pearson and Deviance tests were χ 2=2204.357, P =0.897 and χ 2’=1596.575, P ’=0.967, respectively. The accuracy of prediction was 83.4%. Conclusions Aging, hypertension, acute stroke and previous stroke are independent influencing factors of total CSVD burden, and the prediction model constructed based on the above factors had good predictive value.

Comparison of Rapamycin-Eluting Stent with Bare-Metal Stent in Patients with Symptomatic IntracranialAtherosclerotic Stenosis

LING Yitong, SUN Yujie, LI Guangwen, LIU Tonghui, LI Ye, ZHANG Yong

2022, 17(05): 529-534. DOI: 10.3969/j.issn.1673-5765.2022.05.015

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Objective To observe the clinical efficacy and safety of rapamycin-eluting stent (RES) and baremetal stent (BMS) in treatment of symptomatic intracranial atherosclerotic stenosis (ICAS). Methods This retrospective study enrolled the patients with symptomatic ICAS who were treated with balloon expandable stents in the Affiliated Hospital of Qingdao University from July 2015 to December 2019. The patients were divided into RES group and BMS group. The baseline data, technical success (residual stenosis<30%) rate, complications (including vascular rupture, arterial dissection, in-stent thrombosis, stroke, transient ischemic attack, cerebral hemorrhage, subarachnoid hemorrhage, etc.) rate within 7 days and 1-year in-stent restenosis (stenois>50%) rate were compared between the two groups. Results A total of 116 patients were enrolled in this study, with a mean age of 60.4±8.2 years and 75 males (64.7%), 46 cases in RES group and 70 cases in BMS group. There were no statistical differences in the baseline data, technical success rate and complications rate within 7 days between the two groups. The incidence of 1-year in-stent restenosis in RES group was lower than that in BMS group (0 vs . 20.0%, P =0.012). Conclusions RES has the same safety as the existing BMS in treatment of symptomatic ICAS, and it has a lower 1-year in-stent restenosis rate than BMS.

A Case of Trousseau Syndrome with Dancing Movements of Lateral Limb as the Initial Manifestation of Cerebral Infarction and Literature Review

LI Jing, HUANG Yanlan, ZHONG Yifei, GUO Xiaoyun

2022, 17(05): 535-538. DOI: 10.3969/j.issn.1673-5765.2022.05.016

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A Case Report of Hemophagocytic Syndrom with Multiple Cerebral Infarction

LI Yanxun, LIU Fang, WANG Li, WANG Hui, HE Wen

2022, 17(05): 539-543. DOI: 10.3969/j.issn.1673-5765.2022.05.017

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Multi-modality MRI Assessment of Middle Cerebral Artery Thrombus: A Case Report

LI Linlin, WU Yuqian, ZHANG Yingkui

2022, 17(05): 544-547. DOI: 10.3969/j.issn.1673-5765.2022.05.018

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Application of Zebrafish Model Organism in Stroke Research

MO Dongcan, LIU Liuyu, LI Xiaoling, LI Jianli, LUO Man

2022, 17(05): 548-552. DOI: 10.3969/j.issn.1673-5765.2022.05.019

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Animal model provides a necessary tool for exploring the complex pathophysiological process of cerebrovascular disease and drug development. Zebrafish (Danio rerio) is an ideal spinal model organism, which has the characteristics of small size, strong reproductive capacity, good visibility, short experimental period, and low cost. In addition, the genetic sequence of zebrafish is highly similar to human. It has its own unique advantages in living vascular research, and has been more and more used in stroke research. This paper introduced the characteristics of zebrafish model and its application in stroke research, to provide some help for the follow-up research.

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