Risk Factors of the Type 2 Diabetic Patients Complicated with Stroke
QIAO Yue;GUO Li-Xin;ZHOU Yan;et al
2012, 7(05):
362-369.
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Objective To explore the risk factors of the type 2 diabetic patients complicated with stroke.Methods In this retrospective study we enrolled 2099 patients hospitalized in the Department of Endocrinology, Beijing Hospital from 2003 to 2010. According to stroke, these patients were divided into two groups, type 2 diabetic patients complicated with stroke and the ones without stroke. The general state of health and related indicators were compared and the risk factors of type 2 diabetic patients complicated with stroke were analyzed in this study. Risk factors are slightly different in different gender, we further stratified according to gender, and the risk factors of type 2 diabetic patients complicated with stroke were analyzed respectively.Results Of the 2099 type 2 diabetic patients, 212 cases(10.1%) with stroke were higher than thosewithout stroke in age, waist-hip ratio, duration of diabetes, fasting insulin, 2 hours postmeal insulin, systolic blood pressure, uric acid, the intima-media thickness of carotid artery and the intima-media thickness of femoral artery. The differences were statistically significant(P<0.05). The rates of stroke in diabetic patients with hypertension and coronary heart disease were higher than those without the corresponding events(P<0.05). In male, 130 cases(10.9%)with stroke were higher than those without stroke in age, duration of diabetes, fasting insulin, 2 hours postmeal insulin, total cholesterol, triglycerides, low density lipoprotein cholesterol, uric acid, systolic blood pressure, the intima-media thickness of carotid artery and the intima-media thickness of femoral artery. The differences were statistically significant(P<0.05). In female, 82 cases(9.04%)with stroke were higher than those without stroke in age, waist-hip ratio, duration of diabetes, systolic blood pressure, uric acid, high density lipoprotein cholesterol, the intima-media thickness of carotid artery and the intima-media thickness of femoral artery. The differences were statistically significant(P<0.05). The rates of stroke in diabetic patients with hypertension and coronary heart disease were higher than those without the corresponding events(P<0.05) in different gender. Logistic regression analysis showed that age(odds ratio, OR 1.067, 95% confidence interval, CI 1.021-1.115, P=0.004), intima-media thickness of femoral artery thickness(OR 1.590, 95%CI 1.041-2.431, P=0.032), systolic blood pressure(OR 1.026, 95%CI 1.008-1.044, P=0.004) and coronary heart disease(OR 2.342, 95%CI 1.081-5.070, P=0.031) were related with type 2 diabetic patients complicated with stroke.Conclusions The type 2 diabetic patients complicated with stroke is related with age, waist-hip ratio, duration of diabetes, fasting insulin, 2 hours postmeal insulin, systolic blood pressure and uric acid. The male type 2 diabetic patients complicated with stroke is related with age, duration of diabetes, fasting insulin, 2 hours postmeal insulin, total cholesterol, triglycerides, low density lipoprotein cholesterol, uric acid, systolic blood pressure, the intima-media thickness of carotid artery and the intima-media thickness of femoral artery. The female type 2 diabetic patients complicated with stroke is related with age, waist-hip ratio, duration of diabetes, systolic blood pressure, uric acid, high density lipoprotein cholesterol, the intima-media thickness of carotid artery and the intima-media thickness of femoral artery. Hypertension and coronary heart disease can increase the risk of stroke in male and female patients.
