【Abstract】
Objective To investigate the prevalence and related factors of cerebral microbleeds (CMB) in patients with acute ischemic stroke.
Methods Three hundred and two patients with acute ischemic stroke including all the etiological typings who were hospitalized in Department of Neurology of Beijing No.6 Hospital from January 2011 to June 2012 were successionally recruited. According to whether there were CMB, the patients were divided into two groups, CMB group (83 cases) and non-CMB group (219 cases). Then compare the difference of clinical data including general conditions, biochemical indicators and imaging features between the two groups. The independent risk factors of CMB were analyzed with the Logistic multivariable regression.
Results Among a total of 302 patients, 83 (27.5%) patients had lesions of cerebral microbleeds. Compared with non-CMB group, the age (t=3.67, P<0.001), hypertension (χ2=4.76, P=0.03), history of stroke (χ2=5.46, P=0.02), fibrinogen (t=2.33, P=0.02), number of lacunar infarction (LI) (Z= -5.04, P<0.001) and severity of leukoaraiosis (LA) (Z= -7.88, P<0.001) in the patients with CMB had statistical difference. Logistic regression analysis showed that fibrinogen (OR 1.469, 95%CI 1.366~1.602; P=0.037), number of LI (OR 1.636,95%CI 1.200~2.231; P=0.002) and severity of LA (OR 1.700, 95%CI 1.502~1.980; P<0.001) were the independent risk factors for presence of CMB.
Conclusion CMB had relationships with fibrinogen, number of LI and severity of LA.
