Chinese Journal of Stroke

Unlucky People

WANG Yong-Jun

2013, 8(10): 781-782.

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Post-stroke Epilepsy

KUANG Yi-Fang, DING Mei-Ping

2013, 8(10): 783-785.

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Effects of Long-term Topiramate and Valproate Sodium Monotherapy on Serum Lipid Levels

XIA Man*, YU Jin-Tai, TAN Lan.

2013, 8(10): 786-790.

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Objective To assess the effects of long-term topiramate and valproate sodium monotherapy on serum lipids in patients with epilepsy. Methods Fifty eight adult epilepsy patients who were on antiepileptic drug monotherapy (30 receiving topiramate and 28 receiving valproate sodium) for more than 12 months were recruited. Sixty age and sex matched healthy adults were enrolled in this study as the control group. Serum levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), lipoprotein(a) and triglycerides (TG) were measured in all participants after overnight fasting. Results The group which received the valproate sodium monotherapy showed increased levels of serum lipoprotein(a) except for TC, LDL-C, HDL-C and TG (P>0.05) when compared to the group receiving topiramate (P<0.001) as well as the controls (P=0.003). The group receiving the topiramate monotherapy demonstrated insignificant changes in cholesterol (TC, LDL-C, HDL-C), TG and lipoprotein(a) levels in comparison with the control group. Conclusion Serum lipoprotein(a) level was substantially increased in epilpesy patients on a long-term monotherapy with valproate sodium, whereas long-term topiramate monotherapy might have a minor effect on serum lipids.

Analysis of Twenty-eight Early Seizures after Stroke

ZHENG Cheng-Cai, BAO Yi-Xin, TU Dong-Pei, XU Hui-Qin.

2013, 8(10): 791-794.

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Objective To discuss the incidence rate, clinic manifestation, therapy and prognosis of early seizures after stroke. Methods We reviewed and analyzed the patients at the Department of Neurology in our hospital that had stroke from Jan. 2012 to Feb. 2013. Results Among the 1973 stroke patients, 28 patients attacked by early seizures after stroke, the incidence rate was 1.4%. And the incidence rate was 1.1% (20/1785) when it came to the one who suffered infarction, 3.7% (8/188) as to the cerebral hemorrhage patients (P＜0.001); among the 28 patients 20 were male, the incidence rate was 1.7% (20/1149), 8 were female, the incidence rate was 1.0% (8/824); the seizures types were partial seizure or generalized seizure after partial seizure. The number of the patients whose lesions located in cerebral cortex was 13 (46.4%), 6 (21.4%) patients' lesions located in subcortex, others' (32.2%) located in both cerebral cortex and subcortex. Conclusion The incidence of early seizures after stroke has no significant difference between different genders or the types of stroke, the cortical stroke could cause the early seizures after stroke more easily than subcortical stroke.

Association between Serum Brain-derived Neurotrophic Factor Level and Cognitive Impairment in Patients with Mild Cognitive Impairment

ZHANG Lan-E, YANG Zeng-Yun, HE Bing, Fan Jing-Bo, LU Guo-Hua.

2013, 8(10): 795-798.

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Objective To investigate the relationship between cognitive function and brain-derived neurotrophic factor (BDNF) in mild cognitive impairment and healthy elders. Methods From the community society, we selected 30 samples of mild cognitive impairment (MCI) and 32 control samples. The cognitive function was evaluated by neuropsychological test and the level of BDNF was tested by enzyme-linked immunosorbent assay (ELISA). Results Compared to the control group, the level of BDNF in MCI patients was significantly increased than healthy elders (P=0.025). Also, the level of BDNF in MCI patients was negatively correlated to memory (r=-0.494, P=0.009) and language (r=-0.399, P=0.039) of Mini-Mental State Examination Scale, and positively correlated to the scores of Clinical Dementia Rating Scale (r=0.476, P=0.012). Conclusion The increased level of BDNF in MCI patients showed that BDNF may be involved in the pathophysiology of cognitive impairment.

Effects of Leukoaraiosis on Subsequent Cerebral Vascular Disease and Cognitive Function

LI Xiao-Qing, BI Qi, LIU Pen-Ju.

2013, 8(10): 799-803.

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Objective To determine whether the presence of leukoaraiosis (LA) is a risk factor for subsequent cerebral vascular disease and cognitive impairment. Methods We prospectively examined 253 consecutive outpatients at Department of Neurology of Beijing Anzhen Hospital. The patients were divided into two groups: patients with leukoaraiosis (LA group) and patients without leukoaraiosis (control group). According to the scores, the patients in LA group were divided into mild, moderate and severe groups. Mini Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) (Beijing version) were used to assess the cognitive function. We analyzed clinical data. Patients were then followed up for the development of stroke and cognitive changes. Results In LA group, hypertension and diabetes were more common and there was significant difference between LA and control group (P=0.003 and P=0.004, respectively). The prevalence of cognitive impairment in moderate and severe LA groups was much higher than those in control group (P=0.035 and P=0.019, respectively). The incidences of cerebral infarction in mild, moderate and severe LA group were much higher than those in control group (P=0.019, P=0.024 and P=0.049, respectively). The incidences of cognitive impairment in mild, moderate and severe were much higher than those in control group (P=0.048, P=0.036 and P=0.004, respectively). There was significant difference between LA and control group for the development of cerebral infarction and cognitive impairment. Conclusion The incidence of cerebral infarction and cognitive impairment rose in senile patients with leukoaraiosis.

Post-stroke Epilepsy

DING Mei-Ping

2013, 8(10): 804-804.

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Spontaneous Cervical Artery Dissection and Ischemic Stroke

LIU Juan, ZHOU Hua-Dong,LIU Juan, ZHOU Hua-Dong,

2013, 8(10): 839-843.

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Spontaneous cervical artery dissection (SCAD) is one of the major cause of ischemic stroke in young and middle-aged patients. It is a multifactorial disease involving inheritance, environment, infection in which it is still controversy about the relationship between SCAD and vascular risk factors. Available evidence strongly favors embolism as the most common cause for ischemic stroke. Anticoagulation and antiplatelet are the main treatment options, but randomized trials are lacking to compare both options. There are several single-center studies to evaluate the validity and safety of endovascular stent therapy for SCAD. Most of SCAD has favorable prognosis.

Role of Cerebellum on Vascular Cognitive Impairment

YIN Shun-Xiong*, MIN Lian-Qiu.

2013, 8(10): 844-848.

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The cerebellum is not only associated with the motor, but also the cognitive functions of the non-motor. Vascular cognitive impairment is one of the most important branches among the cognitive function disorder. It has close relations with the risk factors of cerebrovascular disease and old ages. The damage of the nerve cell and nerve fiber bundle caused by cerebral ischemia is the main pathogenesis of vascular cognitive impairment. The strategic positions associated with vascular cognitive impairment include the frontal lobe (especially the prefrontal cortex), anterior cingulate gyrus, hippocampal gyrus, hypothalamus, basal ganglia, parietal lobe (especially the gyrus angular of dominant hemisphere), and temporal cortex, most of which are associated with the cerebellum through the fibers. This article reviews the recent studies about the modular organization and function of the cerebellum, and its relationships with vascular cognitive impairment, to investigate the role of each anatomic site of the cerebellum on vascular cognitive impairment.

Cerebral Vascular Accidents after Percutaneous Coronary Intervention: Incidence, Predictors and Clinical Outcome

YANG Hu-Qin*, HAO Yong-Gang.

2013, 8(09): 849-852.

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Percutaneous coronary intervention-related cerebrovascular accidents (PCI-CVA) is reported to occur in 0.18% to 0.44% of all PCI procedures, which is one of the most debilitating complications. An advanced age, arterial hypertension, diabetes mellitus, history of stroke, congestive heart failure, renal failure, the use of an intra-aortic balloon pump, coronary angiography performed under emergency conditions have been identified as risk factors for PCI-CVA. PCI-CVA patients suffer from longer hospital stay, higher expenses, higher mortality and persistent neurological defects. We can optimize drug therapy, use smaller-caliberguides, and avoid hypotension to reduce the PCI-CVA's incidence.

Improvement of Employment Quality for Postgraduate in Neurology

ZHOU Jian, WANG Lei,ZHANG Rui-Jie, et al.

2013, 8(09): 853-854.

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Clinical Teaching Experience in Moyamoya Disease for Neurosurgical Graduate

DI Fei,ZHANG Dong, ZHANG Yan, et al.

2013, 8(09): 855-856.

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