关键词: 脑血管病; 认知功能; 尼莫地平

Abstract: Objective To observe the efficacy of Nimodipine on vascular cognitive impairment in a shortperiod treatment.Methods It was a prospective opened own control study. Sixty-four patients with cerebrovascular disease were recruited from outpatient of neurology department. On the basis of secondary prevention drugs, patients were given to oral Nimodipine 60-90 mg/d. The patients' cognitive functions have been assessed using the mini mental state examination(MMSE) and Montrealcognitive assessment(MoCA) before and after 12-24 weeks treatment.Results After treatment of Nimodipine, the performance record were significantly better than before, total scores of MMSE were 26.3±2.7 vs 25.6±2.9(P =0.039), MoCA were 20.5±4.6 vs 19.0±4.1(P =0.000), and the memory test of MoCA were significant better than before(1.8±1.7 vs 1.1±1.2, P =0.000).Conclusion Nimodipine may have some benefits for cognitive function in patients with cerebralvascular disease

Key words: Cerebral vascular disease; Cognitive; Nimodipine