关键词: 轻型卒中; 预后; 早期神经功能恶化; 药物依从性

Abstract:

Objective To explore the relationship between 90 days prognosis of patients with minor stroke and drug compliance. Methods A consecutive patients with minor stroke (NIHSS≤3) hospitalized in Tongji Hospital from August 1, 2014 to July 31, 2015 were enrolled in this study. Drug compliance for stroke secondary prevention, stroke recurrence and modified Rankin Scale (mRS) were investigated by telephone or outpatient service at 90 days after onset. mRS≤2 was defined as good prognosis and mRS>2 was defined as poor prognosis. The chi-square test or Fisher's exact test was used statistically to analyze the early neurological deterioration (END), stroke recurrence within 90 days and the impact of drug compliance on prognosis at 90 day of minor stroke. Results A total of 292 cases were successfully followed up at 90 days after onset. Good prognosis rate (mRS≤2) of minor stroke at 90 days was 81.6%, and recurrence rate was 10.4% within 90 days after onset. END rate was 8.2%. The rate of poor outcomes in END group was higher (58.3%) than no-END group (14.9%, P <0.001). The rate of poor outcomes in the recurrence group was higher (86.7%) than the no-recurrence group other group (6.7%, P <0.001). END and stroke recurrence were closely related to the poor prognosis. The rate of good prognosis of compliance of antithrombotic and hypolipidemic agents were 83.5% and 78.1% respectively. The result showed there was no significant correlation between the bad compliance of stroke secondary prevention and unfavorable outcomes.

Conclusion Minor stroke has good prognosis at 90 days after onset and lower recurrence. END and stroke recurrence are closely related to the poor outcomes of minor stroke at 90 days. There is no significant correlation between the bad compliance of stroke secondary prevention and unfavorable 90-day outcomes.

Key words: Minor ischemic stroke; Outcomes; Early neurological deterioration; Drug compliance