[1] VOS T，LIM S S，ABBAFATI C，et al. Global

burden of 369 diseases and injuries in 204 countries

and territories，1990–2019：a systematic analysis for

the Global Burden of Disease Study 2019[J]. Lancet，

2020，396（10258）：1204-1222.

[2] PHAN T G，HASEEB A，BEARE R，et al. Googling

the lifetime risk of stroke around the world[J/OL].

F11：729[2021-02-01]. https：//doi.org/10.3389/f ront

Neurol，2020，neur.2020.00729.

[3] KRISHNAMURTHI R V，IKEDA T，FEIGIN V

L. Global，regional and country-specific burden

of ischaemic stroke，intracerebral haemorrhage

and subarachnoid haemorrhage：a systematic

analysis of the global burden of disease study 2017[J].

Neuroepidemiology，2020，54（2）：171-179.

[4] WANG Y J，LI Z X，GU H Q，et al. China stroke

statistics 2019：a report from the national center

for healthcare quality management in neurological

diseases，China National Clinical Research Center for

Neurological Diseases，the Chinese Stroke Association，

National Center for Chronic and Non-communicable

Disease Control and Prevention，Chinese Center for

Disease Control and Prevention and Institute for Global

Neuroscience and Stroke Collaborations[J]. Stroke

Vasc Neurol，2020，5（3）：211-239.

[5] ILIFF J J，WANG M，LIAO Y，et al. A paravascular

pathway facilitates CSF flow through the brain

parenchyma and the clearance of interstitial solutes，

including amyloid β[J/OL]. Sci Transl Med，2012，4

（147）：147ra111[2021-02-01]. https：//doi.org/10.1126/

scitranslmed.3003748.

[6] LOUVEAU A，SMIRNOV I，KEYES T J，et al.

Structural and functional features of central nervous

system lymphatic vessels[J]. Nature，2015，523（7560）：

337-341.

[7] MESTRE H，DU T，SWEENEY A M，et al.

Cerebrospinal fluid influx drives acute ischemic

tissue swelling[J/OL]. Science，2020，367（6483）：

eaax7171[2021-02-01]. https：//doi.org/10.1126/science.

aax7171.

[8] DHAR R. Automated quantitative assessment

of cerebral edema after ischemic stroke using

CSF volumetrics[J/OL]. Neurosci Lett，2020，

724：134879[2021-02-01]. https：//doi.org/10.1016/

j.neulet.2020.134879.

[9] DHAR R，CHEN Y，HAMZEHLOO A，et al.

Reduction in cerebrospinal fluid volume as an early

quantitative biomarker of cerebral edema after

ischemic stroke[J]. Stroke，2020，51（2）：462-467.

[10] NAGANAWA S，TAOKA T. The glymphatic system：a

review of the challenges in visualizing its structure and

function with MR imaging[J/OL]. Magn Reson Med

Sci，2020[2021-02-01]. https：//doi.org/10.2463/mrms.

rev.2020-0122.

[11] LANGHORNE P，AUDEBERT H J，CADILHAC D A，

et al. Stroke systems of care in high-income countries：

what is optimal?[J]. Lancet，2020，396（10260）：1433-

1442.

[12] PANDIAN J D，KALKONDE Y，SEBASTIAN I A，et

al. Stroke systems of care in low-income and middleincome

countries：challenges and opportunities[J].

Lancet，2020，396（10260）：1443-1451.

[13] MARTINS S O，MONT'ALVERNE F，REBELLO L

C，et al. Thrombectomy for stroke in the public health care system of brazil[J]. N Engl J Med，2020，382

（24）：2316-2326.

[14] YANG P F，ZHANG Y W，ZHANG L，et al.

Endovascular thrombectomy with or without

intravenous alteplase in acute stroke[J]. N Engl J

Med，2020，382（21）：1981-1993.

[15] WANG Y T，WU X，ZHU C C，et al. Bridging

thrombolysis achieved better outcomes than direct

thrombectomy after large vessel occlusion：an

updated meta-analysis[J]. Stroke，2021，52（1）：356-

365.

[16] CAMPBELL B C V，MITCHELL P J，CHURILOV

L，et al. Tenecteplase versus alteplase before

thrombectomy for ischemic stroke[J]. N Engl J Med，

2018，378（17）：1573-1582.

[17] CAMPBELL B C V，MITCHELL P J，CHURILOV

L，et al. Effect of intravenous tenecteplase dose

on cerebral reperfusion before thrombectomy in

patients with large vessel occlusion ischemic stroke：

the EXTEND-IA TNK part 2 randomized clinical

trial[J]. JAMA，2020，323（13）：1257-1265.

[18] THOMALLA G，BOUTITIE F，MA H，et al.

Intravenous alteplase for stroke with unknown time

of onset guided by advanced imaging：systematic

review and meta-analysis of individual patient

data[J]. Lancet，2020，396（10262）：1574-1584.

[19] HILL M D，GOYAL M，MENON B K，et al.

Efficacy and safety of nerinetide for the treatment

of acute ischaemic stroke（ESCAPE-NA1）：a

multicentre，double-blind，randomised controlled

trial[J]. Lancet，2020，395（10227）：878-887.

[20] TARIQ S，SAH R G，CHAN L，et al. Recanalization

following endovascular treatment and imaging

of perfusion，regional infarction and atrophy to

understand stroke evolution-NA1（REPERFUSENA1）[

J]. Int J Stroke，2020，15（3）：343-349.

[21] WANG Y J，WANG Y L，ZHAO X Q，et al.

Clopidogrel with aspirin in acute minor stroke or

transient ischemic attack[J]. N Engl J Med，2013，

369（1）：11-19.

[22] JOHNSTON S C，AMARENCO P，DENISON H，et

al. Ticagrelor and aspirin or aspirin alone in acute

ischemic stroke or TIA[J]. N Engl J Med，2020，383

（3）：207-217.

[23] DING L L，LIU C，LI Z X，et al. Incorporating

artificial intelligence into stroke care and research[J/

OL]. Stroke，2020，51（12）：e351-e354[2021-02-01].

https：//doi.org/10.1161/strokeaha.120.031295.

[24] RIVERA S C，LIU X，CHAN A W，et al. Guidelines

for clinical trial protocols for interventions involving

artificial intelligence：the SPIRIT-AI extension[J].

Nat Med，2020，26（9）：1351-1363.

[25] LIU X，CRUZ RIVERA S，MOHER D，et al.

Reporting guidelines for clinical trial reports for

interventions involving artificial intelligence：the

CONSORT-AI extension[J]. Nat Med，2020，26（9）：

1364-1374.

[26] 熊云云，李子孝，丁玲玲，等. 基于人工智能干预措施

的临床试验方案指南：SPIRIT-AI扩展[J]. 中国卒中

杂志，2020，15（11）：1228-1238.

[27] 李子孝，熊云云，丁玲玲，等. 人工智能干预性临床

试验报告指南：CONSORT-AI扩展[J]. 中国卒中杂

志，2020，15（12）：1327-1336.

[28] KANSAGRA A P，GOYAL M S，HAMILTON S，et

al. Collateral effect of Covid-19 on stroke evaluation

in the United States[J]. N Engl J Med，2020，383（4）：

400-401.

[29] ZHOU Y F，HONG C D，CHANG J，et al.

Intravenous thrombolysis for acute ischaemic stroke

during COVID-19 pandemic in Wuhan，China：a

multicentre，retrospective cohort study[J]. J Neurol

Neurosurg Psychiatry，2021，92（2）：226-228.

[30] KERLEROUX B，FABACHER T，BRICOUT N，et

al. Mechanical thrombectomy for acute ischemic

stroke amid the COVID-19 outbreak：decreased

activity，and increased care delays[J]. Stroke，2020，

51（7）：2012-2017.

[31] AHA/ASA Stroke Council Leadership. Temporary

emergency guidance to US stroke centers during the

coronavirus disease 2019（COVID-19）pandemic：on

behalf of the American Heart Association/American

Stroke Association Stroke Council Leadership[J].

Stroke，2020，51（6）：1910-1912.

[32] TSIVGOULIS G，KATSANOS A H，ORNELLO

R，et al. Ischemic stroke epidemiology during the

COVID-19 pandemic：navigating uncharted waters

with changing tides[J]. Stroke，2020，51（7）：1924-

1926.

[33] LEE M H，PERL D P，NAIR G，et al. Microvascular

injury in the brains of patients with Covid-19[J]. N

Engl J Med，2021，384（5）：481-483.

[34] IADECOLA C，ANRATHER J，KAMEL H. Effects

of COVID-19 on the nervous system[J]. Cell，2020，

183（1）：16-27.

[35] KASHYAP V S，SCHNEIDER P A，FOTEH M，et

al. Early outcomes in the ROADSTER 2 study of

transcarotid artery revascularization in patients with

significant carotid artery disease[J]. Stroke，2020，51

（9）：2620-2629.