泛凋亡与中枢神经系统疾病的研究进展

doi:10.3969/j.issn.1673-5765.2025.08.016

摘要/Abstract

摘要： 泛凋亡（PANoptosis）是一种全新的炎症性程序性细胞死亡形式，由泛凋亡体（PANoptosome）复合物调控并激活，具有细胞焦亡、凋亡和坏死性凋亡的主要特征。泛凋亡在病毒、细菌、真菌感染性疾病中发挥自我防御功能，在炎症性疾病中则加重疾病损伤。本文介绍泛凋亡的定义及分子调控机制，探讨多种细胞死亡形式的串扰和关联关系，阐述泛凋亡在卒中、脑肿瘤、脓毒症相关性脑病、癫痫等中枢神经系统疾病中的作用机制，旨在为中枢神经系统疾病的临床治疗提供新思路。

文章导读： 泛凋亡是整合多种死亡途径的炎症性程序性细胞死亡形式，参与多种中枢神经系统疾病的病理进程，在疾病发生发展中发挥重要调控作用，针对泛凋亡的干预是中枢神经系统疾病精准防治的一种新思路。

关键词: 泛凋亡; 焦亡; 凋亡; 坏死性凋亡; 中枢神经系统疾病

Abstract: PANoptosis, a novel form of inflammatory programmed cell death, is regulated and activated by the PANoptosome complex and possesses the main characteristics of pyroptosis, apoptosis, and necroptosis. PANoptosis plays a self-defense role in viral, bacterial, and fungal infectious diseases, while it exacerbates disease damage in inflammatory diseases. This article summarizes the definition and molecular regulatory mechanisms of PANoptosis, explores the crosstalk and correlations among various forms of cell death, and elaborates on the mechanisms of PANoptosis in central nervous system diseases such as stroke, brain tumors, sepsis-related encephalopathy, and epilepsy, aiming to provide new ideas for the clinical treatment of central nervous system diseases.

Key words: PANoptosis; Pyroptosis; Apoptosis; Necroptosis; Central nervous system disease

中图分类号:

刘嘉, 刘雪梅. 泛凋亡与中枢神经系统疾病的研究进展[J]. 中国卒中杂志, 2025, 20(8): 1058-1065.

LIU Jia, LIU Xuemei. Research Progress on PANoptosis and Central Nervous System Diseases[J]. Chinese Journal of Stroke, 2025, 20(8): 1058-1065.

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