1 Michael S. International Classification of Sleep

Disorders[M]. 3 rd ed. Darien：American Academy of

Sleep Medicine，2014：5-7.

2 中华医学会神经病学分会睡眠障碍学组. 中国成人

失眠诊断与治疗指南[J]. 中华神经科杂志，2012，7：

534-541.

3 Ohayon MM. Epidemiology of insomnia：what we

know and what we still need to learn[J]. Sleep Med

Rev，2002，6：97-111.

4 Soldatos CR，Allaert FA，Ohla T，et al. How do

individuals sleep around the world? Results f Iom

a single-day survey in ten countries[J]. Sleep Med，

2005，6：5-13.

5 中国医师协会. 2015中国睡眠指数报告[EB/OL]. http：

//www.cmda.net/shouyezhiding/2015-03-20/13025.

html(2015-03-20)[2016-05-19].

6 Chen PL，Lee WJ，Sun WZ，et al. Risk of dementia in

patients with insomnia and long-term use of hypnotics：

a population-based retrospective cohort study[J].

PLoS One，2012，7：e49113.

7 Merlino G，Piani A，Gigli GL，et al. Daytime

sleepiness is associated with dementia and cognitive

decline in older Italian adults：a population-based

study[J]. Sleep Med，2010，11：372-377.

8 Andrew SP，Lim MD，Matthew K，et al. Sleep

fragmentation and the risk of incident alzheimer's

disease and cognitive decline in older persons[J].

Sleep，2013，36：1027-1032.

9 Potvin O，Lorrain D，Forget H，et al. Sleep quality

and 1-year incident cognitive impai rment in

community-dwelling older adults[J]. Sleep，2012，35：

491-499.

10 Nebes RD，Buysse DJ，Halligan EM，et al. Selfrepor

ted sleep quality predicts poor cognitive

performance in healthy older adults[J]. J Gerontol B

Psychol Sci Soc Sci，2009，64：180-187.

11 Ramos AR，Dong C，Elkind MS，et al. Association

between Sleep Duration and the Mini-Mental Score：

The Northern Manhattan Study[J]. J Clin Sleep Med，

2013，9：669-673.

12 Lin X，Chao QJ，Tai Hing L，et al. Short or long

sleep duration is associated with memory impairment

in older Chinese：the Guangzhou Biobank Cohort

Study[J]. Sleep，2011，34：575-580.

13 Grandner MA，Drummond SP. Who are the long

sleepers? Towards an undestanding of the mortality

relationship[J]. Sleep Med Rev，2007，11：341-360.

14 Ohayon MM，Vecchierini MF. Daytime sleepiness

and cognitive impairment in the elderly population[J].

Arch Intern Med，2002，162：201-208.

15 Eun YJ，Hosung K，Sooyeon S，et al. Hippocampal

substructural vulnerability to sleep disturbance

and cognitive impairment in patients with chronic

primary insomnia：Magnetic resonance imaging

morphometry[J]. Sleep，2014，37：1189-1198.

16 Spira AP，Gamaldo A，Adam P，et al. Self-reported

sleep and β-amyloid deposition in communitydwelling

older adults[J]. JAMA Neurol，2013，70：

1537-1543.

17 Loke YK，Brown JW，Kwok CS，et al. Association

of obstructive sleep apnea with risk of serious

cardiovascular events：a systematic review and metaanalysis[

J]. Circ Cardiovasc Qual Outcomes，2012，5：

720-728.

18 Yaffe K，Laffan AM，Harrison SL，et al. Sleepdisordered

breathing，hypoxia，and risk of mild

cognitive impairment and dementia in older women[J].

JAMA，2011，306：613-619.

19 Antic NA，Catcheside P，Buchan C，et al. The effect

of CPAP in normalizing daytime sleepiness，quality

of life，and neurocognitive function in patients with

moderate to severe OSA[J]. Sleep，2011，34：111-119.

20 Nikodemova M，Finn L，Mignot E，et al. Association

of sleep disordered breathing and cognitive deficit in

APOE ε4 carriers[J]. Sleep，2013，36：873-880.

21 Thakre TP，Mamtani MR. Lack of association of the

APOE epsilon 4 allele with the risk of obstructive

sleep apnea：meta-analysis and meta-regression[J].

Sleep，2009，32：1507-1511.

22 Meir HK. 睡眠医学理论与实践[M]，北京：人民卫生

出版社，2010.

23 Guarnieri B，Adorni F，Musicco M，et al. Prevalence

of sleep disturbances in mild cognitive impairment

and dementing disorders：a multicenter Italian clinical

cross-sectional study on 431 patients[J]. Dement

Geriatr Cogn Disord，2012，33：50-58.

24 Talarico G，Canevelli M，Tosto G，et al. Restless legs

syndrome in a group of patients with Alzheimer’s

disease[J]. Am J Alzheimers Dis Other Demen，2013，

28：165-170.

25 Rose KM，Beck C，Tsai PF，et al. Sleep disturbances

and nocturnal agitation behaviors in older adults with

dementia[J]. Sleep，2011，34：779-786.

26 Al z heimer’s Di sea s e Inter nat ional. World

Alzheimer Repor t 2015[EB/OL]. ht tp：//www.

worldalzreport2015.org/(2015-8)[2016-05-19].

27 Westerberg CE，Mander BA，Florczak SM，et

al. Concurrent impairments in sleep and memory

in amnestic mild cognitive impairment[J]. J Int

Neuropsychol Soc，2012，18：490-500.

28 Guarnieri B，Adorni F，Musicco M，et al. Prevalence

of sleep disturbances in mild cognitive impairment

and dementing disorders：a multicenter Italian clinical

cross-sectional study on 431 patients[J]. Dement

Geriatr Cogn Disord，2012，33：50-58.

29 Hardeland R. Melatonin in aging and disease - multiple

consequences of reduced secretion，options and limits

of treatment[J]. Aging Dis，2012，3：194-225.

30 Wu YH，Feenstra MG，Zhou JN，et al. Molecular

changes underlying reduced pineal melatonin levels

in Alzheimer disease：alterations in preclinical and

clinical stages[J]. J Clin Endocrinol Metab，2003，88：

5898-5906.

31 Maestri M，Carnicelli L，Tognoni G，et al. Non-rapid

eye movement sleep instability in mild cognitive

impairment：a pilot study[J]. Sleep Med，2015，16：

1139-1145.

32 McKeith IG. Consensus guidelines for the clinical and

pathologic diagnosis of dementia with Lewy bodies

(DLB)：report of the consortium on DLB international

workshop[J]. J Alzheimers Dis，2006，9：417-423.

33 Wade AG，Farmer M，Harari G，et al. Add-on

prolonged-release melatonin for cognitive function

and sleep in mild to moderate Alzheimer's disease：a

6-month，randomized，placebo-controlled，multicenter

trial[J]. Clin Interv Aging，2014，9：947-961.

34 Gagnon JF，Vendette M，Postuma RB，et al. Mild

cognitive impairment in rapid eye movement sleep

behavior disorder and Parkinson’s disease[J]. Ann

Neurol，2009，66：39-47.

35 Postuma RB，Bertrand JA，Montplaisir J，et al.

Rapid eye movement sleep behavior disorder and risk

of dementia in Parkinson’s disease：a prospective

study[J]. Mov Disord，2012，27：720-726.

36 Pos t uma RB，Gagnon JF，Vendet t e M，e t a l .

Quantifying the risk of neurodegenerative disease in

idiopathic REM sleep behavior disorder[J]. Neurology，

2009，72：1296-1300.

37 Mahowald MW，Anderson ML，Silber MH，et al.

Lewy body variant of Alzheimer’s disease (AD)

identified by postmortem ubiquitin staining in a

previously reported case of AD associated with REM

sleep behavior disorder[J]. Biol Psychiatry，42，527-

528.

38 Jiang B，Ding C，Yao G，et al. Polysomnographic

abnormalities in patients with vascular cognitive

impairment-no dementia[J]. Sleep Med，2013，14：

1071-1075.

39 Zhu MF，Deng LY，Gong LM，et al. Macrostructure

of sleep in pat ients with vascular cognit ive

impairment-no dementia[J]. Nan Fang Yi Ke Da Xue

Xue Bao，2011，31：295-298.

40 McCar ter SJ，St Louis EK，Boeve BF. Sleep

disturbances in frontotemporal dementia[J]. Curr

Neurol Neurosci Rep，2016，16：85.

41 Huang Y，Potter R，Sigurdson W，et al. Effects of age

and amyloid deposition on Aβ dynamics in the human

central nervous system[J]. Arch Neurol，2012，69：51-

58.

42 Tarasoff-Conway JM，Carare RO，Osorio RS，et

al. Clearance systems in the brain-implications for

Alzheimer disease[J]. Rev Neurol，2015，11：457-470.

43 Xie L，Kang H，Xu Q，et al. Sleep drives metabolite

clearance from the adult brain[J]. Science，2013，342：

373-377.

44 O'Donnell J，Ding F，Nedergaard M，et al. Distinct

funct ional s tates of a st rocytes dur ing sleep

and wakefulness：Is norepinephrine the master

regulator?[J]. Curr Sleep Med Rep，2015，1：1-8.

45 McKinley J，McCarthy A，Lynch T. Don’t lose sleep

over neurodegeneration-it helps clear amyloid beta[J].

Front Neurol，2013，4：206.