The Study on Influencing Factors of Vascular Cognitive Impairment no Dementia

doi:10.3969/j.issn.1673-5765.2017.01.003

Abstract

Abstract:

Objective To investigate the influencing factors of vascular cognitive impairment no dementia (VCIND). Methods Patients with VCIND in Tangshan Gongren Hospital from January 2014 to January 2016 were recruited into the study group and patients with no cognitive impairment were enrolled into the control group. The differences of vascular risk factors, laboratory data and thyroid hormone were compared between two groups. Logistic regression analysis was used to analyze the independent risk factor. Results There were 115 cases in the study group with VCIND and 147 in the control group. The proportion of hypertension (73.9% vs 53.1%, P =0.001), history of stroke (60.9% vs 34.7%, P <0.001) in the VCIND group was significantly higher than that in the control group. The level of fasting blood glucose (Glu)(P <0.001), homocysteine (Hcy)(P <0.001) and triglyceride (P =0.022) in the VCIND group were significantly higher than that of the control group. The free triiodothyronine (FT3) in the VCIND group was proved lower than that in the control group ([2.80±0.39] pg/ ml vs [2.90±0.27] pg/ml, P =0.043]. Multivariate Logistic regression analysis showed: history of stroke (odds ratio[OR ] 6.461, 95% confidence interval [CI ] 2.835-14.725, P <0.001), Hcy [OR 15.726, 95%CI 7.198-34.358, P <0.001], blood Glu [OR 1.864, 95%CI 1.367-2.541, P <0.001] were independent risk factors of VCIND, and FT3 [OR 0.351, 95%CI 0.192-0.647, P <0.001] were the protective factors of VCIND. Conclusion History of stroke, Hcy and high blood Glu level are independent risk factors of VCIND, while FT3 is the protective factor of VCIND.

Key words: Vascular cognitive impairment; Free triiodothyronine; Influencing factors

摘要：

目的探讨非痴呆性血管性认知障碍的影响因素。方法选取唐山市工人医院2014年1月-2016年1月非痴呆性血管性认知障碍（vascular c ognitive impairment no dementia，VCIND）患者为研究对象，同期认知功能正常者为对照组。对比VCIND组和对照组的血管病危险因素、生化指标、甲状腺激素水平的差异，采用Logi sti c回归分析VCI ND的独立危险因素。结果研究共纳入VCIND组115例，对照组147例。VCIND组患者高血压（73.9% vs 53.1%，P =0.001）及既往卒中史（60.9% vs 34.7%，P＜0.001）比例显著高于对照组。VCIND组空腹血糖（P＜0.001）、同型半胱氨酸（P ＜0.001）、甘油三酯水平显著高于对照组（P =0.022）。VCIND组游离三碘甲状腺原氨酸（free triiodothyronine，FT3）水平显著低于对照组（[ 2.80±0.39）pg/ml vs（2.90±0.27）pg/ml， P =0.043]。多因素分析显示，卒中病史[比值比（odds ratio，OR）6.461，95%可信区间（confidence interval， CI）2.835～14.725，P＜0.001]、同型半胱氨酸（OR 15.726，95%CI 7.198～34.358，P＜0.001）、血糖水平（OR 1.864，95%CI 1.367～2.541，P＜0.001）是VCIND的独立危险因素，而FT3（OR 0.351，95%CI 0.192～0.647，P＜0.001）是VCI ND的保护性因素。结论卒中病史、高血糖水平、高同型半胱氨酸血症是VCI ND的独立危险因素，而FT3是VCI ND的保护性因素。

关键词: 血管性认知障碍; 游离三碘甲状腺原氨酸; 影响因素

MA Hong-Ying, LI Yu-Xia, LI Yong-Qiu, et al.. The Study on Influencing Factors of Vascular Cognitive Impairment no Dementia[J]. Chinese Journal of Stroke, 2017, 12(01): 18-22.

马洪颖，李瑜霞，李永秋，刘春芹，张冬森，王丽英，高轩，高海凤，付子娟. 非痴呆性血管性认知障碍的影响因素研究[J]. 中国卒中杂志, 2017, 12(01): 18-22.

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