The Neuroprotective Effect of Silent Information Regulator Protein 1 in Ischemic Brain Injury

doi:10.3969/j.issn.1673-5765.2018.01.020

Abstract

Abstract:

In recent years, silent information regulator 1 (SIRT1) has been widely studied as a nicotinamide adenine dinucleotide-dependent deacetylase, which exists in various tissues and cells of the body. SIRT1 regulates many cellular physiological processes through the acetylation modification. It plays an important role in energy conservation, cell oxidation, aging and apoptosis, etc. Now, it is believed that SIRT1 plays a vital role of neuroprotection effects in the ischemic brain injury through regulating cell energy metabolism, anti-inflammatory reaction and anti-apoptosis, etc. This paper mainly reviews the research progress on neuroprotection effects of SIRT1 in the ischemic brain injury.

Key words: Silent information regulator protein 1 (SIRT1); Deacetylase; Neuroprotection

摘要：

近年来，沉默信息调节蛋白1（silent information regulator protein 1，SIRT1）作为依赖NAD+ 的组蛋白去乙酰化酶被广泛地研究。SIRT1存在于机体各组织细胞中，通过去乙酰化修饰，调节细胞的多种生理过程，在能量守恒、细胞氧化、衰老及凋亡等方面发挥重要作用。目前认为，SIRT1在缺血性脑损伤中起到神经保护作用，可能通过调控细胞能量代谢，抗炎性反应、抗细胞凋亡等方面发挥作用。本文主要综述了SIRT1在缺血性脑损伤中的神经保护作用。

关键词: 沉默信息调节蛋白1; 去乙酰化酶; 神经保护

LI Chuan-Wen, WANG Qing-Song. The Neuroprotective Effect of Silent Information Regulator Protein 1 in Ischemic Brain Injury[J]. Chinese Journal of Stroke, 2018, 13(01): 86-89.

李传文, 汪青松. 沉默信息调节蛋白1在缺血性脑损伤中的神经保护作用[J]. 中国卒中杂志, 2018, 13(01): 86-89.

References

[1] WRITING GROUP MEMBERS，MOZAFFARIAN

D，BENJAMIN E J，et al. Executive Summary：

Heart Disease and Stroke Statistics--2016 Update：A

Report From the American Heart Association[J].

Circulation，2016，133（4）：447-454.

[2] GUMBINGER C，REUTER B，STOCK C，et

al. Time to treatment with recombinant tissue

plasminogen activator and outcome of stroke in

clinical practice：retrospective analysis of hospital

quality assurance data with comparison with results

from randomised clinical trials[J/OL]. BMJ，2014，

348：g3429. https：//doi.org/10.1136/bmj.g3429

[3] PETEGNIEF V，PLANAS A M. SIRT1 regulation

modulates stroke outcome[J]. Transl Stroke Res，

2013，4（6）：663-671.

[4] MENG X，TAN J，LI M，et al. Sirt1：role under

the condition of ischemia/hypoxia[J]. Cell Mol

Neurobiol，2017，37（1）：17-28.

[5] KWON Y，KIM J，LEE C Y，et al. Expression of

SIRT1 and SIRT3 varies according to age in mice[J].

Anat Cell Biol，2015，48（1）：54-61.

[6] POULOSE N，RAJU R. Sirtuin regulation in aging

and injury[J]. Biochim Biophys Acta，2015，1852

（11）：2442-2455.

[7] RAN M，LI Z，YANG L，et al. Calorie restriction

attenuates cerebral ischemic injury via increasing

SIRT1 synthesis in the rat[J/OL]. Brain Res，

2015，1610：61-68. https：//doi.org/10.1016/

j.brainres.2015.03.043

[8] HATTORI Y，OKAMOTO Y，NAGATSUKA K，et

al. SIRT1 attenuates severe ischemic damage by

preserving cerebral blood flow[J]. Neuroreport，2015，

26（3）：113-117.

[9] WAN D，ZHOU Y，WANG K，et al. Resveratrol

provides neuroprotection by inhibiting

phosphodiesterases and regulating the cAMP/AMPK/

SIRT1 pathway after stroke in rats[J]. Brain Res

Bull，2016，121：255-262. http：//dx.doi.org/10.1016/

j.brainresbull.2016.02.011

[10] WANG L M，WANG Y J，CUI M，et al. A

dietary polyphenol resveratrol acts to provide

neuroprotection in recurrent stroke models by

regulating AMPK and SIRT1 signaling，thereby

reducing energy requirements during ischemia[J]. Eur

J Neurosci，2013，37（10）：1669-1681.

[11] WANG S J，ZHAO X H，CHEN W，et al. Sirtuin

1 activation enhances the PGC-1α/mitochondrial

antioxidant system pathway in status epilepticus[J].

Mol Med Rep，2015，11（1）：521-526.

[12] LIU H，WEI X，KONG L，et al. NOD2 is involved in

the inflammatory response after cerebral ischemiareperfusion

injury and triggers NADPH oxidase

2-derived reactive oxygen species[J]. Int J Biol Sci，

2015，11（5）：525-535.

[13] Hernández-Jiménez M，Hurtado O，Cuartero M I，et

al. Silent information regulator 1 protects the brain

against cerebral ischemic damage[J]. Stroke，2013，44

（8）：2333-2337.

[14] NADTOCHIY S M，YAO H，MCBURNEY M W，et

al. SIRT1-mediated acute cardioprotection[J]. Am J

Physiol Heart Circ Physiol，2011，301（4）：1506-1512.

[15] STEIN S，SCHÄFER N，BREITENSTEIN A，et al.

SIRT1 reduces endothelial activation without affecting

vascular function in ApoE-/- mice[J]. Aging（Albany

NY），2010，2（6）：353-360.

[16] ZHANG R，CHEN H Z，LIU J J，et al. SIRT1

suppresses activator protein-1 transcriptional activity

and cyclooxygenase-2 expression in macrophages[J]. J

Biol Chem，2010，285（10）：7097-7110.

[17] LI M，LU Y，HU Y，et al. Salvianolic acid B protects

against acute ethanol-induced liver injury through

SIRT1-mediated deacetylation of p53 in rats[J].

Toxicol Lett，2014，228（2）：67-74.

[18] FAN H，YANG H C，YOU L，et al. The histone

deacetylase，SIRT1，contributes to the resistance of

young mice to ischemia/reperfusion-induced acute

kidney injury[J]. Kidney Int，2013，83（3）：404-413.

[19]CHAE H D，BROXMEYER H E. SIRT1 deficiency

downregulates PTEN/JNK/FOXO1 pathway to block

reactive oxygen species-induced apoptosis in mouse

embryonic stem cells[J]. Stem Cells Dev，2011，20（7）：

1277-1285.

[20] HSU C P，ZHAI P，YAMAMOTO T，et al. Silent

information regulator 1 protects the heart from

ischemia/reperfusion[J]. Circulation，2010，122（21）：

2170-2182.