Progress on Pregnancy-Associated Cerebral Venous Sinus Thrombosis

doi:10.3969/j.issn.1673-5765.2018.05.025

Abstract

Abstract:

Cerebral venous sinus thrombosis (CVST) is a rare type of cerebrovascular disease, with the features of obstruction of cerebrospinal fluid and elevated intracranial pressure. It is a rare disorder with a relative higher mortality. It is also an important cause of stroke in female adults, especially at the stage of perinatal period and with oral contraceptive. There are some difficulties in early diagnosis of CVST in pregnant females, because of multiple risk factors and complex pathogenesis. This review mainly focuses on the etiology, pathophysiology, clinical manifestation, assist examination and treatment of CVST so as to diagnose at early stage, reduce mortality, optimize the therapeutic protocol, and provide important reference for clinical diagnosis and treatment.

Key words: Cerebral venous sinus thrombosis; Pregnancy; Etiology; Pathophysiology

摘要：

颅内静脉窦血栓（cerebral venous sinus thrombosis，CVST）是指由于多种病因引起的脑静脉回流受阻、颅内高压为特征的特殊类型的脑血管病，具有较高死亡率。成年女性则以口服避孕药物和围产期多见。由于妊娠引起的CVST危险因素较多，发病机制复杂，早期对妊娠合并CVST的诊治具有一定难度。本文结合近几年国内外对妊娠相关CVST的病因和发病机制、临床表现和辅助检查、治疗等几个方面的研究进展进行阐述，以期早期发现、优化治疗方案，降低死亡率，为临床诊治提供依据。

关键词: 颅内静脉窦血栓; 妊娠; 病因; 病理生理机制

WANG Qing, YUAN Jun-Liang. Progress on Pregnancy-Associated Cerebral Venous Sinus Thrombosis[J]. Chinese Journal of Stroke, 2018, 13(05): 527-531.

王晴, 袁俊亮. 妊娠相关颅内静脉窦血栓研究进展[J]. 中国卒中杂志, 2018, 13(05): 527-531.

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