Progress of Crossed Aphasia

doi:10.3969/j.issn.1673-5765.2019.10.019

Abstract

Abstract:

Crossed aphasia (CA) refers to aphasia occurring after right cerebral hemisphere injure in right-handed individuals. The incidence of CA in stroke patients is 0.38%-4.6%. CA includes mirror image crossed aphasia and anomalous crossed aphasia, and impaired oral expression mainly presented with non-fluent aphasia. The mechanism of CA remains unclear. Previous studies have showed that the earlier the rehabilitation, the better the prognosis. This paper reviewed the pathogenesis, clinical features, imaging characteristics and rehabilitation of CA, to provide a reference for diagnosis and treatment of CA.

Key words: Crossed aphasia; Right cerebral hemisphere; Language function

摘要：

交叉性失语是一组由于右利手者右侧大脑半球损伤引起的获得性语言障碍综合征，在卒中患者中的发病率为0.38%～4.6%，包括镜像失语与非典型失语，口语表达障碍多数为非流利性失语。交叉性失语的发病机制目前仍存在争议，越早进行康复训练，预后越好。本文从交叉性失语的发病机制、临床特点、影像学检查及康复训练的研究进展进行综述，以提高临床医师的重视，从而为交叉性失语的诊治提供理论依据。

关键词: 交叉性失语; 右侧大脑半球; 语言功能

JIA Wei-Li, LIU Qi, LI Si-Qi, ZHANG Yu-Mei. Progress of Crossed Aphasia[J]. Chinese Journal of Stroke, 2019, 14(10): 1066-1071.

贾伟丽，刘琪，李思奇，张玉梅. 交叉性失语的研究进展[J]. 中国卒中杂志, 2019, 14(10): 1066-1071.

References

[1] MARIËN P，ENGELBORGHS S，VIGNOLO L A，

et al. The many faces of crossed aphasia in dextrals：

report of nine cases and review of the literature[J].

Eur J Neurol，2001，8（6）：643-658.

[2] 高素荣. 失语症[J]. 医学理论与实践，1994，7（1）：

7-10.

[3] 金雪红，姚潇涵. 脑卒中交叉性失语的临床研究[J].

实用心脑肺血管病杂志，2012，20（11）：1778-1779.

[4] FERRARI C，POLITO C，BERTI V，et al. High

frequency of crossed aphasia in dextral in an

Italian cohort of patients with logopenic primary

progressive aphasia[J/OL]. J Alzheimers Dis，2019.

https：//doi.org/10.3233/JAD-190677.

[5] NISHIDA H，HAYASHI Y，BAN Y，et al. A case

of crossed logopenic primary progressive aphasia

in a dextral patient with underlying frontotemporal

dementia[J/OL]. Intern Med，2019. https：//doi.

org/10.2169/internalmedicine.2301-18.

[6] ZAMMAR S G，SPECHT C S，ZACHARIA B E.

Crossed aphasia as a manifestation of glioblastoma[J/

OL]. Cureus，2018，10（2）：e2239. https：//doi.

org/10.7759/cureus.2239.

[7] UYSAL U，LANDAZURI P，PEARSON C，et

al. Unexpected aphasia following right temporal

lobectomy as treatment of recurrent super-refractory

status epilepticus[J]. Case Rep Neurol，2017，9（2）：

195-203.

[8] PRATER S，ANAND N，WEI L，et al. Crossed

aphasia in a patient with anaplastic astrocytoma of

the non-dominant hemisphere[J]. J Radiol Case Rep，

2017，11（9）：1-9.

[9] KIM W J，YANG E J，PAIK N J. Neural substrate

responsible for crossed aphasia[J]. J Korean Med Sci，

2013，28（10）：1529-1533.

[10] ANNETT M. The theory of an agnosic right shift

gene in schizophrenia and autism[J]. Schizophr Res，

1999，39（3）：177-182.

[11] ALEXANDER M P，ANNETT M. Crossed aphasia

and related anomalies of cerebral organization：case

reports and a genetic hypothesis[J]. Brain Lang，

1996，55（2）：213-239.

[12] VASSAL M，Le BARS E，MORITZ-GASSER S，et

al. Crossed aphasia elicited by intraoperative cortical

and subcortical stimulation in awake patients[J]. J

Neurosurg，2010，113（6）：1251-1258.

[13] RATHORE C，GEORGE A，KESAVADAS C，et

al. Extent of initial injury determines language

lateralization in mesial temporal lobe epilepsy with

hippocampal sclerosis（MTLE-HS）[J]. Epilepsia，

2009，50（10）：2249-2255.

[14] JANSZKY J，MERTENS M，JANSZKY I，et al.

Left-sided interictal epileptic activity induces shift

of language lateralization in temporal lobe epilepsy：

an fMRI study[J]. Epilepsia，2006，47（5）：921-927.

[15] TAN X，GUO Y，DUN S，et al. Crossed aphasia

following cerebral infarction in a right-handed

patient with atypical cerebral language dominance[J].

J Neurol，2018，265（7）：1671-1675.

[16] PATIDAR Y，GUPTA M，KHWAJA G A，et al. A

case of crossed aphasia with apraxia of speech[J].

Ann Indian Acad Neurol，2013，16（3）：428-431.

[17] ISHIZAKI M，UEYAMA H，NISHIDA Y，et al.

Crossed aphasia following an infarction in the right

corpus callosum[J]. Clin Neurol Neurosurg，2012，

114（2）：161-165.

[18] ALEXANDER M P，FISCHETTE M R，FISCHER

R S. Crossed aphasias can be mirror image or

anomalous. Case reports，review and hypothesis[J].

Brain，1989，112（Pt 4）：953-973.

[19] DEWARRAT G M，ANNONI J M，FORNARI E，et

al. Acute aphasia after right hemisphere stroke[J]. J

Neurol，2009，256（9）：1461-1467.

[20] COPPENS P，HUNGERFORD S，YAMAGUCHI S，

et al. Crossed aphasia：an analysis of the symptoms，

their frequency，and a comparison with lefthemisphere

aphasia symptomatology[J]. Brain Lang，

2002，83（3）：425-463.

[21] 孟红. 交叉性失语30例临床分析[J]. 中国当代医药，

2011，18（10）：173，176.

[22] 周延华，张冲，王东，等. 左、右两侧基底神经节损害

致失语症的对比研究[J]. 疾病监测与控制，2015，9

（6）：425-427.

[23] CASTRO-CALDAS A，CONFRARIA A. Age and

type of crossed aphasia in dextrals due to stroke[J].

Brain Lang，1984，23（1）：126-133.

[24] MAESHIMA S，UEYOSHI A，MATSUMOTO

T，et al. Quantitative assessment of impairment in constructional ability by cube copying in patients

with aphasia[J]. Brain Inj，2002，16（2）：161-167.

[25] JEONG E H，LEE Y J，KWON M，et al.

Agrammatic primary progressive aphasia in

two dextral patients with right hemispheric

involvement[J]. Neurocase，2014，20（1）：46-52.

[26] CABRERA-MARTÍN M N，MATÍAS-GUIU J

A，YUS-FUERTES M，et al. 18F-FDG PET/CT

and functional MRI in a case of crossed logopenic

primary progressive aphasia[J]. Rev Esp Med Nucl

Imagen Mol，2016，35（6）：394-397.

[27] VITALI P，DRONKERS N，PINCHERLE A，et

al. Accuracy of pre-surgical fMRI confirmed by

subsequent crossed aphasia[J]. Neurol Sci，2011，32

（1）：175-180.

[28] SPINELLI E G，CASO F，AGOSTA F，et al. A

multimodal neuroimaging study of a case of

crossed nonfluent/agrammatic primary progressive

aphasia[J]. J Neurol，2015，262（10）：2336-2345.

[29] 王伶杰，张洧，李映凯，等. 交叉性失语语言功能

重组的功能磁共振研究[J]. 中国老年学杂志，2017

（20）：5007-5010.

[30] DE-TORRES I，DÁVILA G，BERTHIER M L，et

al. Repeating with the right hemisphere：reduced

interactions between phonological and lexicalsemantic

systems in crossed aphasia?[J/OL].

Front Hum Neurosci，2013，7：675. https：//doi.

org/10.3389/fnhum.2013.00675.

[31] TORRISI M，POLLICINO P，CORALLO

F，et al. A case report on crossed aphasia in

dextrals：consideration about clinical features

and neural network[J/OL]. Medicine（Baltimore），

2019，98（43）：e17660. https：//doi.org/10.1097/

MD.0000000000017660.

[32] 齐晶. 脑卒中后交叉性失语26例临床病例分析[J]. 中

外健康文摘，2013（18）：106-107.

[33] 张庆苏，李胜利，贾革红，等. 4例交叉性失语患者的

言语症状及其康复[J]. 中国康复理论与实践，2002

（1）：43-44.

[34] BERTHIER M L，DE-TORRES I，PAREDESPACHECO

J，et al. Cholinergic potentiation and

audiovisual repetition-imitation therapy improve

speech production and communication deficits in a

person with crossed aphasia by inducing structural

plasticity in white matter tracts[J]. Front Hum

Neurosci，2017，11：304. https：//doi.org/10.3389/

fnhum.2017.00304.

[35] RAYMER A M，BANDY D，ADAIR J C，et al.

Effects of bromocriptine in a patient with crossed

nonfluent aphasia：a case report[J]. Arch Phys Med

Rehabil，2001，82（1）：139-144.

[36] LU H，WU H，CHENG H，et al. Improvement

of white matter and functional connectivity

abnormalities by repetitive transcranial magnetic

stimulation in crossed aphasia in dextral[J]. Int J

Clin Exp Med，2014，7（10）：3659-3668.

[37] JUNG T D，KIM J Y，LEE Y S，et al. Effect of

repetitive transcranial magnetic stimulation in a

patient with chronic crossed aphasia：fMRI study[J].

J Rehabil Med，2010，42（10）：973-978.

[38] MUNERA C P，LOMLOMDJIAN C，SOLIS P，et

al. Crossed aphasia after right anterior temporal

lobectomy. A case report[J]. Epilepsy Behav，2012，

25（1）：125-128.