[1] WANG W，JIANG B，SUN H，et al. Prevalence，

incidence，and mortality of stroke in China：results

from a nationwide population-based survey of

480 687 adults[J]. Circulation，2017，135（8）：759-

771.

[2] WANG D，LIU J，LIU M，et al. Patterns of stroke

between university hospitals and nonuniversity

hospitals in mainland China：prospective

multicenter hospital-based registry study[J/OL].

World Neurosurg，2017，98：258-265. https：//doi.

org/10.1016/j.wneu.2016.11.006.

[3] JAUCH E C，SAVER J L，ADAMS H P Jr，et al.

Guidelines for the early management of patients with

acute ischemic stroke：a guideline for healthcare

professionals from the American Heart Association/

American Stroke Association[J]. Stroke，2013，44

（3）：870-947.

[4] 王伊龙，王拥军，吴敌，等. 中国卒中防治研究现状

[J]. 中国卒中杂志，2007，2（1）：20-37.

[5] 中国卒中学会急救医学分会. 脑卒中院前急救专家

共识[J]. 中华急诊医学杂志，2017，26（10）：1107-

1114.

[6] ECC Committee，Subcommittees and Task Forces

of the American Heart Association. 2005 American

Heart Association guidelines for cardiopulmonary

resuscitation and emergency cardiovascular care[J].

Circulation，2005，112（24 suppl）：Ⅳ1-203.

[7] European Stroke Organisation（ESO）Executive

Committee，ESO Writing Committee. Guidelines

for management of ischaemic stroke and transient

ischaemic attack 2008[J]. Cerebrovasc Dis，2008，25

（5）：457-507.

[8] ADAMS H P Jr，DEL ZOPPO G，ALBERTS M

J，et al. Guidelines for the early management of

adults with ischemic stroke：a guideline from the

American Heart Association/American Stroke

Association Stroke Council，Clinical Cardiology

Council，Cardiovascular Radiology and Intervention

Council，and the Atherosclerotic Peripheral Vascular

Disease and Quality of Care Outcomes in Research

Interdisciplinary Working Groups：the American

Academy of Neurology affirms the value of this

guideline as an educational tool for neurologists[J/

OL]. Circulation，2007，115（20）：e478-e534.

https：//doi.org/10.1161/CIRCULATIONAHA.107.

181486.

[9] BRAY J E，MARTIN J，COOPER G，et al. An

interventional study to improve paramedic diagnosis

of stroke[J]. Prehosp Emerg Care，2005，9（3）：297-302.

[10] 中国老年医学学会急诊医学分会，中华医学会急诊

医学分会卒中学组，中国卒中学会急救医学分会. 急

性缺血性脑卒中急诊急救中国专家共识2018[J]. 中

国卒中杂志，2018，13（9）：956-967.

[11] MORRIS D L，ROSAMOND W，MADDEN K，et

al. Prehospital and emergency department delays

after acute stroke：the Genentech Stroke Presentation

Survey[J]. stroke，2000，31（11）：2585-2590.

[12] POWERS W J，RABINSTEIN A A，ACKERSON

T，et al. 2018 Guidelines for the early management

of patients with acute ischemic stroke：a guideline

for healthcare professionals from the American

Heart Association/American Stroke Association[J/

OL]. Stroke，2018，49（3）：e46-e110. https：//doi.

org/10.1161/STR.0000000000000158.

[13] SAVER J L，GOYAL M，VAN DER LUGT A，et al.

Time to treatment with endovascular thrombectomy

and outcomes from ischemic stroke：a metaanalysis[

J]. JAMA，2016，316（12）：1279-1288.

[14] FARGEN K M，JAUCH E，KHATRI P，et al.

Needed dialog：regionalization of stroke systems of

care along the trauma model[J]. Stroke，2015，46（6）：

1719-1726.

[15] 国家卫生和计划生育委员会神经内科医疗质量控

制中心. 中国卒中中心建设指南[J]. 中国卒中杂志，

2015，10（6）：499-507.

[16] 楼敏，张旭婷. 卒中中心的区域化建设[J]. 中国卒中

杂志，2015，10（6）：457-460.

[17] 张玉生，徐安定. 加快构建区域性卒中急救网络建设

[J]. 中国卒中杂志，2018，13（2）：102-105.

[18] EBINGER M，WINTER B，WENDT M，et a1.

Effect of the use of ambulance-based thrombolysis

on time to thrombolysis in acute ischemic stroke：a

randomized clinical trial[J]. JAMA，2014，311（16）：

1622-1631.

[19] WALTER S，KOSTOPOULOS P，HAASS A，et al.

Diagnosis and treatment of patients with stroke in a

mobile stroke unit versus in hospital：a randomized

controlled trial[J]. Lancet Neurol，2012，11（5）：

397-404.

[20] National Institute of Neurological Disorders

and Stroke rt-PA Stroke Study Group. Tissue

plasminogen activator for acute ischemic stroke[J].

N Engl J Med，1995，333（24）：1581-1587.

[21] HACKE W，KASTE M，BLUHMKI E，et a1.

Thrombolysis with alteplase 3 to 4. 5 hours after

acute ischemic stroke[J]. N Engl J Med，2008，359

（13）：1317-1329.

[22] THOMALLA G，SIMONSEN C Z，BOUTITIE

F，et al. MRI-guided thrombolysis for stroke with

unknown time of onset[J]. N Engl J Med，2018，379

（7）：611-622.

[23] CAMPBELL B C V，MA H，RINGLEB P A，et

al. Extending thrombolysis to 4.5-9 h and wake-up

stroke using perfusion imaging：a systematic review

and meta-analysis of individual patient data[J].

Lancet，2019，394（10193）：139-147.

[24] EMBERSON J，LEES K R，LYDEN P，et al. Effect

of treatment delay，age，and stroke severity on the

effects of intravenous thrombolysis with alteplase for

acute ischaemic stroke：a meta-analysis of individual

patient data from randomised trials[J]. Lancet，2014，

384（9958）：1929-1935.

[25] ASADI H，DOWLING R，YAN B，et al. Advances

in endovascular treatment of acute ischemic stroke[J].

Intern Med J，2015，45（8）：798-805.

[26] GOYAL M，MENON B K，VAN ZWAM W H，et

a1. Endovascular thrombectomy after large-vessel

ischaemic stroke：a meta-analysis of individual

patient data from five randomised trials[J]. Lancet，

2016，387（10029）：1723-1731.

[27] NOGUEIRA R G，JADHAV A P，HAUSSEN D C，

et al. Thrombectomy 6 to 24 hours after stroke with

a mismatch between deficit and infarct[J]. N Engl J

Med，2018，378（1）：11-21.

[28] ALBERS G W，MARKS M P，KEMP S，et al.

Thrombectomy for stroke at 6 to 16 hours with

selection by perfusion imaging[J]. N Engl J Med，

2018，378（8）：708-718.

[29] 中华医学会神经病学分会神经重症协作组，中国医

师协会神经内科医师分会神经重症委员会. 大脑半

球大面积梗死监护与治疗中国专家共识[J]. 中华医

学杂志，2017，97（9）：645-652.

[30] JÜTTLER E，SCHWAB S，SCHMIEDEK P，et

al. Decompressive Surgery for the Treatment of

Malignant Infarction of the Middle Cerebral Artery

（DESTINY）：a randomized，controlled trial[J].

Stroke，2007，38（9）：2518-2525.

[31] ZHAO J，SU Y Y，ZHANG Y，et al. Decompressive

hemicraniectomy in malignant middle cerebral artery

infarct：a randomized controlled trial enrolling

patient up to 80 years old[J]. Neurocrit Care，2012，17

（2）：161-171.

[32] AIYAGARI V，DEIBERT E，DIRINGER M N.

Hypernatremia in the neurologic intensive care unit：

how high is too high?[J]. J Crit Care，2006，21（2）：

163-172.

[33] VAHEDI K，HOFMEIJEI J，JUETTLER E，et al.

Early decompressive surgery in malignant infarction

of the middle cerebral artery：a pooled analysis of

three randomized controlled trials[J]. Lancet Neurol，2007，6（3）：215-222.

[34] JÜTTLER E，UNTERBERY A，WOITZIK J，et al.

Hemicraniectomy in older patients with extensive

middle-cerebral-artery stroke[J]. N Engl J Med，

2014，370（12）：1091-1100.

[35] 中华医学会神经病学分会神经重症协作组. 神经重

症低温治疗中国专家共识[J]. 中华神经科杂志，2015，

48（6）：453-458.

[36] 宿英英，黄旭升，潘速跃，等. 神经疾病并发医院获

得性肺炎诊治共识[J]. 中华神经科杂志，2012，45

（10）：752-756.

[37] DENNIS M，MORDI N，GRAHAM C，et al. The

timing，extent，progression and regression of

deep vein thrombosis in immobile stroke patients：

observational data from the CLOTS multicenter

randomized trials[J]. J Thromb Haemost，2011，9

（11）：2193-2200.

[38] CHALOUHI N，DAOU B，RINCON F，et al. Risk

of venous thromboembolism in patients with large

hemispheric infarction undergoing decompressive

hemicraniectomy[J]. Neurocrit Care，2016，25（1）：

105-109.