Progress of Functional Neural Networks for Space Navigation

doi:10.3969/j.issn.1673-5765.2022.01.014

Abstract

Abstract: Spatial positioning ability is an advanced cognitive function, and there are obvious individual differences. The spatial navigation neural network system in the brain is the structural basis of spatial positioning. The hippocampus, entorhinal cortex, parahippocampus, retrosplenial cortex and the thalamus are the cerebral cortex related to spatial navigation function. Place cells, head-oriented cells, grid cells, intermediate neurons, boundary cells, integrated cells and movement-sensitive cells are the main cells involved in spatial navigation. The spatial navigation neural network pathway is formed by the interaction between cerebral cortex and spatial cells related to spatial navigation. This article reviewed the brain regions, spatial cells and neural network pathways related to spatial navigation function, so as to provide a starting point for further research in spatial orientation ability in the future.

Key words: Spatial navigation; Hippocampus; Spatial cell; Neural network

摘要： 空间定位能力是一种高级认知功能，个体之间存在明显差异。大脑内部的空间导航神经网络系统是空间定位能力的结构基础。海马区、内嗅区、海马旁回、压后皮质和丘脑是与空间导航功能相关的大脑皮质。位置细胞、头向细胞、网格细胞、中间神经元、边界细胞、整合细胞和运动敏感性细胞是参加空间导航功能的主要细胞。与空间导航相关的大脑皮质及细胞相互作用形成空间导航神经网络通路。本文对与空间导航功能相关的大脑区域、空间细胞及神经网络通路进行综述，以期为今后深入研究空间定位能力提供切入点。

关键词: 空间导航; 海马; 空间细胞; 神经网络

WANG Huihui, BAI Qiuju, CHANG Linli, ZHANG Yanhai, CHI Liyi. Progress of Functional Neural Networks for Space Navigation[J]. Chinese Journal of Stroke, 2022, 17(01): 97-102.

王会会, 白秋菊, 常琳丽, 张彦海, 迟丽屹. 空间导航功能神经网络研究进展[J]. 中国卒中杂志, 2022, 17(01): 97-102.

References

[1] HAO X，HUANG Y，LI X T，et al. Structural and functional neural correlates of spatial navigation：a combined voxel-based morphometry and functional connectivity study[J/OL]. Brain Behav，2016，6（12）：e00572[2021-09-02]. https：//doi.org/10.1002/brb3.572.
[2] ISMAKOV R，BARAK O，JEFFERY K，et al. Grid cells encode local positional information[J/OL]. Curr Biol，2017，27（15）：2337-2343，e3[2021-09-02]. https：//doi.org/10.1016/j.cub.2017.06.034.
[3] ZHÀO H Y，CHI L Y，ZHANG Y H，et al . Spatial navigation is impaired in elderly patients with cerebral small vessel disease[J/OL]. Front Neurol，2021，12：608797[2021-09-02]. https：//doi.org/10.3389/fneur.2021.608797.
[4] HAMRE C，FURE B，HELBOSTAD J L，et al. Impairments in spatial navigation during walking in patients 70 years or younger with mild stroke[J]. Top Stroke Rehabil，2020，27（8）：601-609.
[5] DANJO T. Allocentric representations of space in the hippocampus[J/OL]. Neurosci Res，2020，153：1-7[2021-09-02]. htt ps：//doi.org/10.1016/j.neures.2019.06.002.
[6] O'KEEFE J，DOSTROVSKY J. The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat[J]. Brain Res，1971，34（1）：171-175.
[7] O'KEEFE J，NADEL L. The hippocampus as a cognitive map[M]. New York：Oxford University Press，1978.
[8] RANCK J B. Head-direction cells in the deep cell layers of dorsal presubiculum in freely moving rats[J]. Soc Neurosci Abstr，1984，10（176）：12.
[9] FYHN M，MOLDEN S，WITTER M P，et al. Spatial representation in the entorhinal cortex[J]. Science，2004，305（5688）：1258-1264.
[10] HAFTING T，FYHN M，MOLDEN S，et al. Microstructure of a spatial map in the entorhinal cortex[J]. Nature，2005，436（7052）：801-806.
[11] 汪云九. 身在何处——2014年诺贝尔生理学或医学奖介绍[J]. 自然杂志，2014，36（6）：409-414.
[12] KONG X Z，WANG X，PU Y，et a l. Human navigat ion net work：the intrinsic functional organization and behavioral relevance[J]. Brain Struct Funct，2017，222（2）：749-764.
[13] TAUBE J S，MULLER R U，RANCK J B. Headdirection cells recorded from the postsubiculum in freely moving rats. Ⅱ. Effects of environmental manipulations[J]. J Neurosci，1990，10（2）：436-447.
[14] TAUBE J S. The head direction signal：origins and sensory-motor integration[J/OL]. Annu Rev Neurosci，2007，30：181-207[2021-09-02]. https：//doi.org/10.1146/annurev.neuro.29.051605.112854.
[15] LISMAN J，BUZSÁKI G，EICHENBAUM H，et al. Viewpoints：how the hippocampus contributes to memory，navigation and cognition[J]. Nat Neurosci，2017，20（11）：1434-1447.
[16] FOGWE L A，R EDDY V，MESF I N F B . Neu roanatomy，h i p p o c a m p u s [ M ]. Florida： StatPearls Publishing，2018.
[17] ROWLAND D C，ROUDI Y，MOSER M B，et al. Ten years of grid cells[J/OL]. Annu Rev Neurosci，2016，39：19-40[2021-09-02]. https：//doi.org/10.1146/annurev-neuro-070815-013824.
[18] GOODE T D，TANAKA K Z，SAHAY A，et al. An integrated index：engrams，place cells，and hippocampal memory[J]. Neuron，2020，107（5）：805-820.
[19] PEYRACHE A，DUSZKIEWICZ A J，VIEJO G，et al. Thalamocortical processing of the headdirection sense[J/OL]. Prog Neurobiol，2019，183：101693[2021-09-02]. https：//doi.org/10.1016/j.pneurobio.2019.101693.

[20] BAUMANN O，MATTINGLEY J B. Extrahippocampal contributions to spatial navigation in humans：a review of the neuroimaging evidence[J]. Hippocampus，2021，31（7）：640-657.
[21] WAGATSUMA H，YAMAGUCHI Y. Neural dynamics of the cognitive map in the hippocampus[J]. Cogn Neurodyn，2007，1（2）：119-141.
[22] J IN W J，QIN H，ZHANG K，et a l. Spatial navigation[J/OL]. Adv Exp Med Biol，2020，1284：63-90[2021-09-02]. https：//doi.org/10.1007/978-981-15-7086-5_7.
[23] EDVARDSEN V，BICANSKI A，BURGESS N. Navigating with grid and place cells in cluttered environments[J]. Hippocampus，2020，30（3）：220-232.
[24] SKAGGS W E，MCNAUGHTON B L，WILSON M A，et al. Theta phase precession in hippocampal neuronal populations and the compression of temporal sequences[J]. Hippocampus，1996，6（2）：149-172.
[25] GRIEVES R M，JEFFERY K J. The representation of space in the brain[J/OL]. Behav Processes，2017，135：113-131[2021-09-02]. https：//doi.org/10.1016/j.beproc.2016.12.012.
[26] 于乃功，方略，罗子维，等. 一种网格细胞到位置细胞的高斯分布激活函数模型[J]. 生物医学工程学杂志，2016，33（6）：1158-1167.
[27] DUMONT J R，TAUBE J S. The neural correlates of navigation beyond the hippocampus[J/OL]. Prog Brain Res，2015，219：83-102[2021-09-02]. https：//doi.org/10.1016/bs.pbr.2015.03.004.
[28] BOOKER S A，VIDA I. Morphological diversity and connectivity of hippocampal interneurons[J]. Cell Tissue Res，2018，373（3）：619-641.
[29] LONG X Y，ZHANG S J. A novel somatosensory spatial navigation system outside the hippocampal formation[J]. Cell Res，2021，31（6）：649-663.
[30] EPSTEIN R A，PATAI E Z，JULIAN J B，et al. The cognitive map in humans：spatial navigation and beyond[J]. Nat Neurosci，2017，20（11）：1504-1513.
[31] VEDDER L C，MILLER A M P，HARRISON M B，et al. Retrosplenial cortical neurons encode navigational cues，trajectories and reward locations during goal directed navigation[J]. Cereb Cortex，2017，27（7）：3713-3723.
[32] 于乃功，李倜，方略. 海马空间认知机理及其在仿生机器人导航中的应用[J]. 生物工程前沿：中英文版，2015，4（1）：1-14.
[33] 卢建. 内嗅皮层-海马输出端的空间探索功能图谱[D]. 重庆：第三军医大学，2016.
[34] SHARIF F，TAYEBI B，BUZSÁKI G，et al. Subcircuits of deep and superficial CA1 place cells support efficient spatial coding across heterogeneous environments[J/OL]. Neuron，2021，109（2）：363-376，e6[2021-09-02]. https://doi.org/10.1016/j.neuron.2020.10.034.
[35] KASSAB R，ALEXANDRE F. Pattern separation in the hippocampus：distinct circuits under different conditions[J]. Brain Struct Funct，2018，223（6）：2785-2808.
[36] KITAMURA T，MACDONALD C J，TONEGAWA S. Entorhinal-hippocampal neuronal circuits bridge temporally discontiguous events[J]. Learn Mem，2015，22（9）：438-443.