Progress of Blood Pressure and Post-stroke Cognitive Impairment

doi:10.3969/j.issn.1673-5765.2023.01.006

Abstract

Abstract: Post-stroke cognitive impairment is one of the common complications of stroke, which can seriously affect the quality of life and prognosis of stroke patients. At present, it is believed that blood pressure is closely related to post-stroke cognitive impairment. Blood pressure may have a potential impact on the main pathophysiology of post-stroke cognitive impairment, and blood pressure control may contribute to the improvement or prevention of post-stroke cognitive impairment. However, the correlation between blood pressure and post-stroke cognitive impairment may depend on specific blood pressure parameters and different stages of stroke. But there is no consensus on the optimal level of blood pressure control after stroke so far. This article reviewed the epidemiology of post-stroke cognitive impairment, the correlation between blood pressure and post-stroke cognitive impairment, the mechanisms of the effect of blood pressure on post-stroke cognitive impairment, and the role of blood pressure control, to provide an important basis for further elucidation of pathophysiological process of post-stroke cognitive impairment and provide reference for clinical practice.

Key words: Stroke; Blood pressure; Post-stroke cognitive impairment; Antihypertensive drug

摘要： 卒中后认知障碍为卒中的常见并发症之一，可严重影响卒中患者的生活质量及预后。目前认为血压与卒中后认知障碍密切相关，血压可能对卒中后认知障碍的主要病理生理过程产生潜在影响，并且控制血压可能有助于卒中后认知障碍的改善或预防。血压与卒中后认知障碍之间的相关性较为复杂，可能取决于特定的血压参数和卒中的不同阶段。目前卒中后的最佳血压控制水平尚不统一。本文对卒中后认知障碍的流行病学，血压与卒中后认知障碍的相关性，血压影响卒中后认知障碍的相关机制，以及控制血压的作用进行综述，为进一步阐明卒中后认知障碍的病理生理过程提供重要依据，以期有助于指导临床治疗，从而改善卒中患者的预后。

关键词: 卒中; 血压; 卒中后认知障碍; 降压药物

WU Yating, WEI Chenming, WU Jian. Progress of Blood Pressure and Post-stroke Cognitive Impairment[J]. Chinese Journal of Stroke, 2023, 18(01): 68-75.

吴雅婷, 魏宸铭, 武剑. 卒中患者血压水平与卒中后认知障碍关系的研究进展[J]. 中国卒中杂志, 2023, 18(01): 68-75.

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