Research Progress on the Correlation between Neuroinflammation and Brain Iron Metabolism after Intracerebral Hemorrhage

doi:10.3969/j.issn.1673-5765.2024.10.014

Abstract

Abstract: Intracerebral hemorrhage refers to bleeding caused by non-traumatic rupturing of blood vessels within the brain, which is a serious neurological disorder. Its main pathophysiological characteristics include massive bleeding and neuron death, which impair the neuroimmune system and severely affect the patient’s prognosis. Iron ion homeostasis is crucial for maintaining normal neurological function. However, following intracerebral hemorrhage, disrupted iron metabolism leads to iron accumulation in the brain. Excessive iron participates in neuroinflammatory responses by activating inflammatory signaling pathways and regulating the function of inflammatory cells, while neuroinflammatory cells also participate in regulating the transportation and storage of iron ions. The interaction between the two exacerbates neurol damage. This article reviews the progress of research on the correlation between neuroinflammation and brain iron metabolism after intracerebral hemorrhage, aiming to provide a reference for the clinical treatment of intracerebral hemorrhage.

Key words: Intracerebral hemorrhage; Iron; Iron metabolism; Neuroinflammation

摘要： 脑出血是指脑实质内非外伤性血管破裂引起的出血，是一种严重的神经系统疾病。其主要病理生理特点包括大量出血和神经元死亡，可损害神经免疫系统，严重影响患者的预后。铁离子稳态对维持神经系统的正常功能至关重要，然而脑出血发生后的铁代谢紊乱会导致脑内铁积聚。过量的铁通过激活炎症信号通路、调节炎症细胞功能等途径参与神经炎症反应，而神经炎症细胞也调节铁离子的运输和储存，两者相互作用共同加重神经损伤。本文综述了脑出血后神经炎症与脑铁代谢的相关研究进展，旨在为脑出血的临床治疗提供参考。

关键词: 脑出血; 铁; 铁代谢; 神经炎症

CLC Number:

JU Jiajun, WANG Xinxin, HANG Lihua. Research Progress on the Correlation between Neuroinflammation and Brain Iron Metabolism after Intracerebral Hemorrhage[J]. Chinese Journal of Stroke, 2024, 19(10): 1205-1214.

鞠佳俊, 王心心, 杭黎华. 脑出血后神经炎症与脑铁代谢的相关性研究进展[J]. 中国卒中杂志, 2024, 19(10): 1205-1214.

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