Correlations between Linguistic Functions and Non-Linguistic Cognitive Functions in Patients with Post-Stroke Wernicke’s Aphasia

doi:10.3969/j.issn.1673-5765.2025.08.007

Abstract

Abstract: Objective To investigate the relationship between non-linguistic cognitive function and language impairment in patients with post-stroke Wernicke’s aphasia (WA).
Methods A prospective cohort of patients with post-ischemic stroke WA was consecutively enrolled from the Department of Rehabilitation Medicine, Beijing Tiantan Hospital, Capital Medical University from March 2021 to March 2024. Linguistic function was assessed using the western aphasia battery-revised (WAB-R), including spontaneous speech, auditory comprehension, repetition, and naming. Non-linguistic cognitive function was evaluated using the Loewenstein occupational therapy cognitive assessment (LOTCA), covering orientation, visual perception, spatial perception, motor application, visuomotor organization, thinking operations, and attention. Spearman correlation analysis was used to explore the relationships between various subtests of linguistic functions and non-linguistic cognitive functions. Linear regression analysis was performed with auditory comprehension and naming scores from the WAB-R as dependent variables respectively, and the scores of each LOTCA subtest as independent variables, to assess the influence of non-linguistic cognitive functions on auditory comprehension and naming abilities.
Results A total of 25 patients with WA aged 27 to 73 years were included in this study. Spearman correlation analysis showed that scores of orientation, spatial perception, and motor application in LOTCA were positively correlated with auditory comprehension and naming scores in WAB-R. Linear regression analysis revealed that orientation scores in LOTCA were positively correlated with auditory comprehension scores in WAB-R (P=0.048), visual perception scores in LOTCA were negatively correlated with auditory comprehension scores in WAB-R (P=0.041).
Conclusions In WA patients, non-linguistic cognitive functions such as orientation, spatial perception, and application are positively correlated with language functions like auditory comprehension and naming, while visual perception is negatively correlated with auditory comprehension.

Key words: Ischemic stroke; Wernicke’s aphasia; Non-linguistic cognitive function

摘要： 目的探讨卒中后感觉性失语症[韦尼克失语症（Wernicke’s aphasia，WA）]非语言认知功能与语言障碍的关系。
方法前瞻性连续纳入2021年3月—2024年3月于首都医科大学附属北京天坛医院康复医学科住院的缺血性卒中后WA患者。采用西方失语成套测验-修订版（western aphasia battery-revised，WAB-R）评估语言功能（包括自发言语、听理解、复述和命名）；采用洛文斯顿作业疗法认知评定成套测验（Loewenstein occupational therapy cognitive assessment，LOTCA）评估非语言认知功能（包括定向力、视知觉、空间知觉、动作运用、视运动组织、思维操作和注意力）。通过Spearman相关性分析探究语言功能与非语言认知功能各子项之间的关系；分别以WAB-R中的听理解和命名得分为因变量，以LOTCA各子项得分为自变量进行线性回归分析，以评估非语言认知功能对听理解和命名的影响。
结果本研究共纳入25例年龄27～73岁的WA患者。Spearman相关性分析显示，LOTCA中的定向力、空间知觉及动作运用得分与WAB-R中的听理解及命名得分呈正相关。线性回归分析结果显示，LOTCA中的定向力得分与WAB-R中的听理解得分呈正相关（P=0.048），LOTCA中的视知觉得分与WAB-R中的听理解得分呈负相关（P=0.041）。
结论 WA患者的定向力、空间知觉和动作运用等非语言认知功能与其听理解和命名等语言功能存在正相关关系，而视知觉则与听理解呈负相关关系。

关键词: 缺血性卒中; 感觉性失语症; 非语言认知功能

CLC Number:

LU Xiao, ZHANG Yumei, CHEN Xinya. Correlations between Linguistic Functions and Non-Linguistic Cognitive Functions in Patients with Post-Stroke Wernicke’s Aphasia[J]. Chinese Journal of Stroke, 2025, 20(8): 985-991.

卢肖, 张玉梅, 陈心雅. 卒中后感觉性失语症患者语言功能与非语言认知功能的相关性[J]. 中国卒中杂志, 2025, 20(8): 985-991.

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