Abstract: Small deep cerebral infarcts, often referred to lacunes，have been traditionally associated withsmall-vessel disease affecting the deep penetrating arterial system. However, small deep cerebralinfarcts with ipsilateral large cerebral artery disease are often observed. The aim of this articleis to investigate the relationship between the small deep cerebral infarcts and the large arterydisease. This article reviewed 21 pieces of related literatures aboard which discussed the pattern ofcerebral infarcts in stenotic or occluded cerebral arteries of anterior circulation, and the potentialmechanisms of small deep cerebral infarcts caused by large artery disease. Large cerebral arterydisease can also cause the small deep cerebral infarcts like “lacunar infarcts”.

Key words: Small deep cerebral infarcts; Border-zone infarcts; Penetrating artery infarcts; Large cerebral artery disease

摘要： 小的深部脑梗死多数被认为与小血管病变有关，常与腔隙性脑梗死划为同一范畴。然而，小的深部脑梗死经常与同侧颅内外大动脉病变同时存在。本文目的即在于探讨二者之间的关系。本文共回顾了21篇国外相关文献，主要涉及前循环大动脉狭窄梗死的类型以及大动脉狭窄所致小的深部脑梗死的发病机制。颅内外大动脉病变能够造成类似“腔隙性梗死”的小的深部脑梗死。

关键词: 小的深部脑梗死; 交界区梗死; 腔隙性梗死; 大动脉病变