Abstract: Objective To analyze the effect of carotid artery stenting(CAS) on cognitive function for thepatients with internal carotid artery(ICA) stenosis.Methods Total 116 patients with ICA stenosis were treated with carotid artery stenting. All thepatients were examined with mini-mental state examination(MMSE) and P300 before and aftertreatment of 1, 3 and 6 months.Results Technical success was achieved in all the patients, with no CAS-related complicationsduring periprocedure. The residual post-procedure stenosis was 4.5%±6.0%, with significantreduction from pre-procedure stenosis (84%±15%, P <0.01). Before the treatment the score ofMMSE and the latent phase of P300 were 20±5 and 434±78 ms, respectively. After treatment of 1,3 and 6 months the scores of MMSE were elevated significantly and the latent phases of P300 wereshortened significantly, especially on 6 months follow-up. The patients had no recurrent transientischemia attach(TIA) or stroke during the follow-up.Conclusion Carotid artery stenosis is related to cognitive impairment. Endovascular stenting forICA stenosis can improve cognitive function during short-term follow-up.

Key words: Carotid artery stenosis; Cognitive impairment; Angioplasty; Stenting

摘要： 目的 观察缺血性卒中患者颈动脉支架成形术（CAS）对患者认知功能的影响。方法 116例颈动脉狭窄患者行颈动脉支架成形术，在支架置入前及置入后1、3、6个月应用简易精神状态检查量表（MMSE）、P300观察认知功能的变化，同时对患者卒中的复发进行登记。结果 所有患者均成功置入支架，围手术期无手术相关的并发症；支架置入前颈动脉的狭窄率为84%±15%，支架置入后颈动脉狭窄率为4.5%±6.0%，明显缩小；支架置入前患者的MMSE评分及P300潜伏期分别为20±5和434±78 ms，在治疗后随访的1、3及6个月，MMSE明显提高而P300明显缩短；而且随随访时间延长，P300及MMSE变化越明显；在随访期内患者无症状性卒中复发。结论 颈动脉狭窄是导致认知功能障碍的原因之一，CAS可以改善患者的认知功能。

关键词: 颈动脉狭窄; 认知功能损害; 血管成形术; 支架