Abstract: Objective To quantitatively assess the neovascularization within human carotid atheroscleroticplaque in patients with ischemic stroke by real-time contrast-enhanced ultrasonography.Methods Ninety-six patients with carotid atherosclerotic plaques were examined with real-timecontrast-enhanced ultrasonography and divided into two groups: Stroke group including sixtyeightpaitents with ischemic stroke and non-stroke group including twenty-eight patients withoutischemic stroke. Carotid atherosclerotic plaques were detected using the real-time contrastenhancedultrasonography and analyzed using coded phase-inversion harmonic ultrasound(CPI)technology analysis software. The results of the two groups were compared.Results The enhanced rate and enchanced intensity of stroke group was significantly higher thanthat of non-stroke group(P <0.05). The arrival time(AT) and the time to peak(TTP) have significantlydifference in different position of the same group(P <0.05), and did not have significantly differencein the same position of different group(P >0.05).Conclusion The real-time contrast-enhanced ultrasonography can assess the neovascularizationwithin carotid atherosclerotic plaque non-invasively and quantitatively, and provide valuableinformation for plaque risk stratification. The density of intraplaque nevascularization in carotidarteries on ischemic stroke is higher than that of the control group.

Key words: Ultrasonography; interventional; Aotrography; Carotid artery diseases; Carotid stenosis; Neovascularization; pathologic; Brain infarction

摘要： 目的 探讨实时超声造影在定量评价缺血性卒中患者颈动脉硬化斑块内新生血管中的应用价值。方法 96例颈动脉硬化斑块患者分为卒中组（68例）与非卒中组（28例），应用实时超声造影分别对颈动脉硬化斑块进行检测，运用编码反相谐波成像技术软件在机分析，并进行组间比较。结果 卒中组斑块增强率及增强强度与非卒中组比较明显升高，差异有统计学意义（P <0.05）；同组间比较造影剂到达斑块时间及达峰值时间均迟于颈动脉，差异有统计学意义（P <0.05），不同组别相同部位比较造影剂到达时间及达峰值时间差异无统计学意义（P >0.05）。结论 超声造影可实时观察斑块内新生血管情况，评价斑块易损性。缺血性卒中患者颈动脉斑块新生血管密度高于非卒中患者。

关键词: 超声检查; 介入性; 血管造影术; 颈动脉疾病; 颈动脉狭窄; 新生血管; 病理性; 脑梗死