Abstract: Objective To appraise the effect of Human Albumins in the acute severe cerebral infarction patients.Methods Eighty acute severe cerebral infarction patients were divided into 2 groups. Conventional therapy was applied in the 2 groups, and Human Albumins was used conventionally in treatment group(n=44), whereas it was used in control group(n=36) only when serum albumin was less than 25g/L. Following treatment for 2 weeks, Scandinavian Stroke Scale and Glasgow Coma Scale were evaluated, and the incidence of complications was compared in the 2 groups.Results After treatment, clinical neurologic impairment score of treatment group was significantly lower than that of control group(P<0.05). Coma scale of treatment group was significantly higher than that of control group(P<0.05). The incidence of complications, such as pulmonary infection, renal dysfunction, stress, ulcer and hypoproteinemia, was all higher than that of control group(P<0.05).Conclusion Human Albumins was significant effective for acute severe cerebral infarction patients and could decrease the incidence of complications of severe cerebral infarction patients.

Key words: Brain infarction; Albumins; Treatment outcome; complication

摘要： 目的 观察人血白蛋白治疗急性重症缺血性卒中的疗效。方法 收集急性重症缺血性卒中患者80例，分为两组。治疗组44例，在常规治疗的基础上加用20%人血白蛋白50ml静脉滴注2次/d，连用5d，之后酌情间断应用；对照组36例，仅在血清白蛋白低于25g/L时加用人血白蛋白。比较治疗前、治疗2周后两组间神经功能缺损程度评分和Glasgow昏迷评分的变化，以及治疗期间两组间并发症的发生率。结果 治疗组神经功能缺损评分明显低于对照组（P<0.05），而Glasgow昏迷评分明显高于对照组（P<0.05）；治疗组肺部感染、肾功能不全、应激性溃疡、低蛋白血症等并发症的发生率均明显低于对照组（P<0.05）。结论 人血白蛋白治疗急性重症缺血性卒中的疗效显著，且能降低重症缺血性卒中患者并发症的发生率。

关键词: 脑梗死; 白蛋白; 治疗结果; 并发症