Abstract: Objective To investigate the clinical manifestations, characteristics, and risk factors of intra-andextra-cranial elongation and stenosis.Methods Two thousand two hundred and eighteen patients aged 45 to 89 years old were enrolledto perform aortocranial angiography. Arterial abnormality were classified as arterial elongation andstenosis based on the DSA images. The clinical manifestation was categorized as dizziness, TIAand cerebral infarction, while the risk factors included advanced age, primary hypertension anddiabetes mellitus. Distribution of arterial elongation and stenosis and their clinical manifestationswere compared using Chi-Square test, and multiple risk factors of intra-and extra-cranial elongationand stenosis were analysed by Logistic regression analysis.Results Arterial elongation and stenosis were observed in 1816 patients from 2218 patients,occurence of arterial elongation and stenosis was 76.1% or 23.9% separately. For patients withS- or O-typed elongation in internal carotid arteries, occurence of cerebral infarction was 40.0%or 47.9%. For patients with S- or O-typed elongation in vertebro-basilar arteris, the occurenceof TIA was 57.6% or 25.0%. For severe stenosis in internal carotid artery, occurence of TIA andcerebral infarction was 45.3% or 35.8%. For moderate and severe stenosis in vertebro-basilar artery,occurence of TIA was 48.6% or 48.4% separately. In addition, age (OR=3.28, 95% CI 2.16-4.75),BMI (OR =2.95, 95% CI 2.02-4.31), primary hypertension (OR =3.17, 95% CI 2.12-4.69) anddiabetes mellitus (OR =2.82, 95% CI 1.96-3.87) were related to the occurence of intra-and extracranialelongation and stenosis.Conclusion The arterial elongation and stenosis severity exhibited a significant correlation to theclinical manifestation. And age, BMI, primary hypertension and diabetes were risk factors of theintra-and extra-cranial elongation and stenosi

Key words: Constriction; pathologic; Symptoms & signs; Risk factors

摘要： 目的 研究颅内外动脉纡曲狭窄特点与临床表现及相关危险因素。方法 2218例45～89岁患者行全脑血管造影术。根据数字减影血管造影（d igi tal s u btracti onangiography，DSA）影像，将颅内外动脉形态分为动脉纡曲延长和狭窄，临床特点分为头痛头昏、短暂性脑缺血发作（transient ischemic attack，TIA）和脑梗死，危险因素包括高龄、原发性高血压及糖尿病等。应用χ2检验，对动脉纡曲延长、狭窄分布及临床特点进行比较。应用Logistic回归分析对颅内外动脉狭窄纡曲的危险因素进行多因素分析。结果 2218例造影显示动脉纡曲延长和狭窄1816例，动脉纡曲延长发生率为76.1%，动脉狭窄发生率为23.9%。颈内动脉系统“S”型纡曲和“O”型纡曲临床表现为脑梗死分别为40.0%和47.9%。椎-基底动脉系统“S”型纡曲和“O”型纡曲临床表现为TIA，分别为57.6%和25.0%。颈内动脉系统重度狭窄临床表现为TIA（45.3%）和脑梗死（35.8%）。椎-基底动脉系统中、重度狭窄临床表现为TIA，分别为48.6%和48.4%。年龄（OR =3.28，95% CI 2.16～4.75）、原发性高血压（OR =3.17，95% CI2.12～4.69）、体质指数（body mass index，BMI）（OR =2.95，95% CI 2.02～4.31）和糖尿病（OR =2.82，95% CI 1.96～3.87）与颅内外动脉狭窄纡曲密切相关。结论 颅内外动脉纡曲类型及狭窄程度与临床表现之间有明显相关性，颅内外动脉纡曲狭窄的危险因素主要为年龄、原发性高血压、BMI和糖尿病等。

关键词: 狭窄; 病理性; 症状和体征; 危险因素