Abstract: Animal experiments has revealed that there are much of apoptotic cells inischemic region, especially in penumbra during the first several hours or days after an ischemicevent, which accounts for the parts of the total lesions during the initial stages of ischemia. It iscurrently accepted that cerebral ischemia triggers two general pathways of apoptosis: the intrinsicand extrinsic pathway. This brief review provides a general overview of current knowledges ofapoptotic mechanisms after ischemia.

Key words: Brain ischemia; Ischemic penumbra; Apoptosis; Intrinsic pathway; Extrinsicpathway

摘要： 动物实验证明，脑缺血事件发生后的几小时至几天时间里，缺血区域尤其是缺血半暗带区域存在着大量的细胞凋亡，它构成了最初阶段脑缺血总体损害的一部分。目前认为，脑缺血启动了两条主要的凋亡路径：内源性凋亡路径和外源性凋亡路径。脑缺血后抗凋亡治疗的研究成为目前脑缺血治疗新的研究方向。本文就当前脑缺血后细胞凋亡机制的研究现状作一综述。

关键词: 脑缺血; 缺血半暗带; 细胞凋亡; 内源性途径; 外源性途径