Chinese Journal of Stroke ›› 2014, Vol. 9 ›› Issue (11): 975-979.

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Advances in the Study of the Association between Uric Acid and Carotid Atherosclerotic
Plaque

  

  1. *Department of Neurology, Beijing
    Tiantan Hospital, Capital Medical University, Beijing 100050, China
  • Received:2013-08-20 Online:2014-11-20 Published:2014-11-20

尿酸与颈动脉粥样硬化斑块的关系研究进展

李勍1,2,赵锡海3,赵性泉1   

  1. 1首都医科大学附属北京
    天坛医院神经内科
    2新疆自治区人民医院神
    经内科
    3清华大学医学院生物医
    学影像研究中心
  • 通讯作者: 赵性泉 zxq@vip.163.com
  • 基金资助:

    北京市科委2011年度科
    技计划重大项目《缺
    血性脑卒中高危预警
    体系建立和规范研究》
    (D111107003111007)

Abstract:

Although in the past decade a large number of studies have been performed to identify the relationship between uric acid and carotid atherosclerotic plaques, the issue remains unresolved and it is not clear whether the correlation between uric acid and carotid plaques is circumstantial or causal. This review will evaluate the association between uric acid and carotid atherosclerotic plaques. Some studies have found uric acid may have a role in the pathogenesis of carotid plaques, whereas others have failed to identify uric acid as a significant and independent risk factor after controlling for other atherosclerotic risk factors. Furthermore, uric acid, an endogenous antioxidant, may have a neuroprotective role. More trials are required to provide definite answers in clinical practice in the future.

Key words: Uric acid; Hyperuricemia; Carotid artery, Atherosclerosis; Plaque

摘要:

目前尚不清楚尿酸和颈动脉粥样硬化斑块之间是否有直接或间接的因果关系。一些研究 发现,尿酸可能在颈动脉粥样硬化斑块的发病机制中起作用;而另外一些研究显示尚不能确定尿酸 是独立危险因素。此外,尿酸作为一种内源性抗氧化剂,可能有神经保护作用。为找到明确的答案, 仍然需要进行更多基础和临床试验研究。

关键词: 尿酸; 高尿酸血症; 颈动脉; 动脉粥样硬化; 斑块