Cerebral Large-artery Disease Correlates of White Matter Hyperintensities

Abstract

Abstract:

The cerebral vascular tree is composed of cerebral large vessels and cerebral small vessels, which are structurally and functionally connected. Recently, more and more studies concern about the relationship of large-artery disease and cerebral small vessel disease (CSVD). Atherosclerosis, dolichoectasia and stiffness represent different pathophysiological and structural change of large artery. Cerebral white matter hyperintensities (WMH) is a surrogate marker of CSVD. This article reviews the association of large artery atherosclerosis, dolichoectasia and stiffness with WMH to demonstrate the relationship of large-artery disease and CSVD.

Key words: Cerebral artery stenosis; Cerebral small vessel disease; Cerebral white matter
hyperintensities

摘要：

脑大、小血管共同构成了脑的血管树，它们在结构和功能上有一定的相关性。近年来，脑大血管病变与脑小血管病之间相关关系的研究逐渐受到重视。大动脉粥样硬化、动脉延长扩张及管壁僵硬度增大从不同侧面反映了大血管病变的特点，脑白质高信号是脑小血管病重要的影像学表现。本文对动脉粥样硬化、动脉延长扩张及僵硬度增大与脑白质高信号之间的相关性进行综述，以探讨脑大血管病变与脑小血管病的关系。

关键词: 脑动脉狭窄; 脑小血管病; 脑白质高信号

ZHAI Fei-Fei, ZHU Yi-Cheng. Cerebral Large-artery Disease Correlates of White Matter Hyperintensities[J]. Chinese Journal of Stroke, 2015, 10(12): 1020-1025.

翟菲菲，朱以诚. 脑大动脉病变与脑白质高信号的相关性研究进展[J]. 中国卒中杂志, 2015, 10(12): 1020-1025.

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