Research Advance in Neurogenic Inflammation Induced by Subarachnoid Hemorrhage

doi:10.3969/j.issn.1673-5765.2017.11.016

Abstract

Abstract:

Aneurysmal subarachnoid hemorrhage (aSAH) was a common cerebrovascular disease. With the improvement of clinical surgical technology, the aneurysms can be treated and the mortality caused by rehaemorrhagia decreased, while there were few effective therapeutic measures in allusion to subarachnoid hemorrhage. It was known that neuroinflammation response played a critical role in pathological process after subarachnoid hemorrhage. Studies had shown that inflammation was associated with vasospasm and brain injury. Many preclinical studies had been conducted to explore the correlation between neuroinflammation and aSAH, and the researchers found that inflammatory mediator played an important role in this process. This article provided an overview of the neuroinflammation after aSAH and its pathogenic mechanism.

Key words: Aneurysmal subarachnoid hemorrhage; Cerebral vasospasm; Neuroinflammation response; Delayed cerebral ischemia

摘要：

动脉瘤性蛛网膜下腔出血（aneurysmal subarachnoid hemorrhage，aSAH）是一种常见的脑血管疾病。临床手术技术的提高虽然能够治疗动脉瘤，降低因再次出血而导致患者死亡的概率。但是，目前尚无有效的针对蛛网膜下腔出血并发症的治疗方法。神经系统的炎症反应在蛛网膜下腔出血后的病理过程中起着重要的作用，现研究已表明炎症反应与脑血管痉挛以及脑组织损伤相关。因此，大量的临床前研究也针对神经炎症与aSAH之间的相关性展开，并发现炎症介质在其中发挥着重要的作用。本文就已知的aSAH后神经炎症反应及其发生机制作一综述。

关键词: 动脉瘤性蛛网膜下腔出血; 脑血管痉挛; 神经炎症反应; 迟发性脑缺血

WANG Yong-Peng, ZHANG Tong-Yu, ZHANG Guang, XU Shan-Cai, ZHENG Bing-Jie, SHI Huai-Zhang. Research Advance in Neurogenic Inflammation Induced by Subarachnoid Hemorrhage[J]. Chinese Journal of Stroke, 2017, 12(11): 1061-1066.

王永朋，张彤宇，张广，徐善才，郑秉杰，史怀璋. 蛛网膜下腔出血后神经炎症反应的研究进展[J]. 中国卒中杂志, 2017, 12(11): 1061-1066.

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