Progress of Non-motor Dysfunction after Cerebellar Stroke

doi:10.3969/j.issn.1673-5765.2022.08.018

Abstract

Abstract: At present, the new understanding of non-motor function of cerebellum is based on the comprehensive evidence of neuroanatomy, neuroimaging and clinical research. In clinical practice, the understanding of this aspect for doctors is insufficient, so they often ignore the symptoms of non-motor function impairment of patients with cerebellar stroke. This article mainly discussed the research progress of non-motor dysfunction after cerebellar stroke from the aspects of anatomy, mechanism, and clinical manifestations including cognition, language, emotion and other non-motor function.

Key words: Cerebellar stroke; Cognition; Emotion; Language

摘要： 目前对小脑非运动功能的新认识是基于神经解剖学、神经影像学和临床研究的综合证据，临床上对其认识不足，因此小脑卒中患者的非运动功能损害症状常常被忽视。目前研究认为小脑的非运动功能主要包括认知、语言及情绪、情感等方面。本文主要从解剖、小脑非运动功能的神经调控模式和临床表现等方面对小脑卒中后非运动功能障碍的研究进展进行阐述。

关键词: 小脑卒中; 认知; 情感; 语言

MU Haoyue, JIANG Ruixuan, WANG Yan, JU Yi, ZHAO Xingquan. Progress of Non-motor Dysfunction after Cerebellar Stroke [J]. Chinese Journal of Stroke, 2022, 17(08): 905-910.

穆浩月, 姜睿璇, 王琰, 鞠奕, 赵性泉. 小脑卒中后非运动功能障碍的研究进展[J]. 中国卒中杂志, 2022, 17(08): 905-910.

References

[1] LEINER H C，LEINER A L，DOW R S. Dow，does the cerebellum contribute to mental skills?[J]. Behav Neurosci，1986，100（4）：443-454.
[2] BOTEZ M I，GRAVEL J，ATTIG E，et al. Reversible chronic cerebellar ataxia after phenytoin intoxication：possible role of cerebellum in cognitive thought[J]. Neurology，1985，35（8）：1152-117.
[3] SCHMAHMANN J D. An emerging concept. The cerebellar contribution to higher function[J]. Arch Neurol，1991，48（11）：1178-1187.
[4] SCHMAHMANN J D，SHERMAN J C. The cerebellar cognitive affective syndrome[J]. Brain，1998，121（4）：561-579.
[5] STOODLEY C J，SCHMAHMANN J D. Evidence for topographic organization in the cerebellum of motor control versus cognitive and affective processing[J]. Cortex，2010，46（7）：831-844.
[6] SUSSMAN D，LEUNG R C，CHAKRAVARTY M M，et al. The developing human brain：age-related changes in cortical，subcortical，and cerebellar anatomy[J/OL]. Brain Behav，2016，6（4）：e00457[2021-11-25]. https://doi.org/10.1002/brb3.457.
[7] XUE A H P，KONG R，YANG Q，et al. The detailed organization of the human cerebellum estimated by intrinsic functional connectivity within the individual[J]. J Neurophysiol，2021，125（2）：358-384.
[8] KING M，HERNANDEZ-CASTILLO C R，POLDRACK R A，et al. Functional boundaries in the human cerebellum revealed by a multi-domain task battery[J]. Nat Neurosci，2019，22（8）：1371-1378.
[9] BOSTAN A C，DUM R P，STRICK P L. Functional anatomy of basal ganglia circuits with the cerebral cortex and the cerebellum[J/OL]. Prog Neurol Surg，2018，33：50-61[2021-11-25]. https://doi.org/10.1159/000480748.
[10] D'ANGELO E. Physiology of the cerebellum[J/OL]. Handb Clin Neurol，2018，154：85-108[2021-11-25]. https://doi.org/10.1016/B978-0-444-63956-1.00006-0.
[11] SHIM H G，LEE Y S，KIM S J. The emerging concept of intrinsic plasticity：activity-dependent modulation of intrinsic excitability in cerebellar purkinje cells and motor learning[J]. Exp Neurobiol，2018，27（3）：139-154.
[12] HONDA T，NAGAO S，HASHIMOTO Y，et al. Tandem internal models execute motor learning in the cerebellum[J]. Proc Natl Acad Sci，2018，115（28）：7428-7433.
[13] ARGYROPOULOS，G The cerebellum，internal models and prediction in 'non-motor' aspects of language：a critical review[J/OL]. Brain Lang，2016，161：4-17[2021-11-25]. https://doi.org/10.1016/j.bandl.2015.08.003.
[14] GUELL X，GABRIELI J D E，SCHMAHMANN J D. Embodied cognition and the cerebellum：perspectives from the dysmetria of thought and the universal cerebellar transform theories[J/OL]. Cortex，2018，100：140-148[2021-11-25]. https://doi.org/10.1016/j.cortex.2017.07.005.
[15] RAMNANI N. Automatic and controlled processing in the corticocerebellar system[J/OL]. Prog Brain Res，2014，210：255-285[2021-11-25]. https://doi.org/10.1016/B978-0-444-63356-9.00010-8.
[16] OHMAE S，KUNIMATSU J，TANAKA M. Cerebellar roles in self-timing for sub- and supra-second intervals[J]. J Neurosci，2017，37（13）：3511-3522.
[17] DIEDRICHSEN J，KING M，HERNANDEZ-CASTILLO C，et al. Universal transform or multiple functionality? Understanding the contribution of the human cerebellum across task domains[J]. Neuron，2019，102（5）：918-928.
[18] TASKIRAN-SAG A，UZUNCAKMAK UYANIK H，UYANIK S A，et al. Prospective investigation of cerebellar cognitive affective syndrome in a previously non-demented population of acute cerebellar stroke[J]. J Stroke Cerebrovasc Dis，2020，29（8）：104923.
[19] AHMADIAN N，VAN BAARSEN K，VAN ZANDVOORT M，et al. The cerebellar cognitive affective syndrome-a meta-analysis[J]. Cerebellum，2019，18（5）：941-950.
[20] HELEVEN E，VAN DUN K，VAN OVERWALLE F. The posterior cerebellum is involved in constructing social action sequences：an fMRI study[J]. Sci Rep，2019，9（1）：11110.
[21] FAN L，HU J，MA W Y，et al. Altered baseline activity and connectivity associated with cognitive impairment following acute cerebellar infarction：a resting-state fMRI study[J/OL]. Neurosci Lett，2019，692：199-203[2021-11-25]. https://doi.org/10.1016/j.neulet.2018.11.007.
[22] PATAY Z. Postoperative posterior fossa syndrome：unraveling the etiology and underlying pathophysiology by using magnetic resonance imaging[J]. Childs Nerv Syst，2015，31（10）：1853-1858.
[23] PLEGER B，TIMMANN D. The role of the human cerebellum in linguistic prediction，word generation and verbal working memory：evidence from brain imaging，non-invasive cerebellar stimulation and lesion studies[J/OL]. Neuropsychologia，2018，115：204-210[2021-11-25]. https://doi.org/10.1016/j.neuropsychologia.2018.03.012.
[24] PETERBURS J，CHENG D T，DESMOND J E. The association between eye movements and cerebellar activation in a verbal working memory task[J]. Cereb Cortex，2016，26（9）：3802-3813.
[25] LESAGE E，HANSEN P C，MIALL R C. Right lateral cerebellum represents linguistic predictability[J]. J Neurosci，2017，37（26）：6231-6241.
[26] GEVA S，SCHNEIDER L M，ROBERTS S，et al. The effect of focal damage to the right medial posterior cerebellum on word and sentence comprehension and production[J/OL]. Front Hum Neurosci，2021，15：664650[2021-11-25]. https://doi.org/10.3389/fnhum.2021.664650.
[27] TANI T，SAKAI Y. Stuttering after right cerebellar infarction：a case study[J]. J Fluency Disord，2010，35（2）：141-145.
[28] FRANK B，MASCHKE M，GROETSCHEL H，et al. Aphasia and neglect are uncommon in cerebellar disease：negative findings in a prospective study in acute cerebellar stroke[J]. Cerebellum，2010，9（4）：556-566.
[29] STAROWICZ-FILIP A，CHROBAK A A，MILCZAREK O，et al. The visuospatial functions in children after cerebellar low-grade astrocytoma surgery：a contribution to the pediatric neuropsychology of the cerebellum[J]. J Neuropsychol，2017，11（2）：201-221.
[30] LEFORT J M，ROCHEFORT C，RONDI-REIG L. Cerebellar contribution to spatial navigation：new insights into potential mechanisms[J]. Cerebellum，2015，14（1）：59-62.
[31] LEFORT J M，ROCHEFORT C，RONDI-REIG L，et al. Cerebellar contribution to spatial realignment：a tDCS study during multiple-step prism adaptation[J/OL]. Neuropsychologia，2018，112：58-65[2021-11-25]. https://doi.org/10.1007/s12311-015-0653-0.
[32] KIM E J，CHOI K D，HAN M K，et al. Hemispatial neglect in cerebellar stroke[J]. J Neurol Sci，2008，275（1/2）：133-138.
[33] BAREŠ M，APPS R，AVANZINO L，et al. Consensus paper：decoding the contributions of the cerebellum as a time machine from neurons to clinical applications[J]. Cerebellum，2019，18（2）：266-286.
[34] TANAKA S Y，HIRANO M，FUNASE K. Modulation of cerebellar brain inhibition during temporal adaptive learning in a coincident timing task[J]. Exp Brain Res，2021，239（1）：127-139.
[35] RUFENER K S，HUSEMANN A M，ZAEHLE T. The internal time keeper：causal evidence for the role of the cerebellum in anticipating regular acoustic events[J/OL]. Cortex，2020，133：177-187[2021-11-25]. https://doi.org/10.1016/j.cortex.2020.09.021.
[36] NOZARADAN S，SCHWARTZE M，OBERMEIER C，et al. Specific contributions of basal ganglia and cerebellum to the neural tracking of rhythm[J/OL]. Cortex，2017，95：156-168[2021-11-25]. https://doi.org/10.1016/j.cortex.2017.08.015.
[37] PETACCHI A，KAERNBACH C，RATNAM R，et al. Increased activation of the human cerebellum during pitch discrimination：a positron emission tomography（PET）study[J]. Hear Res，2011，282（1/2）：35-48.
[38] GUILHERME E M，GIANLORENÇO A C L. The effects of intravermis cerebellar microinjections of dopaminergic agents in motor learning and aversive memory acquisition in mice[J/OL]. Front Behav Neurosci，2021，15：628357[2021-11-25]. https://doi.org/10.3389/fnbeh.2021.628357.
[39] KASHYAP R，ENG G K，BHATTACHARJEE S，et al. Individual-fMRI-approaches reveal cerebellum and visual communities to be functionally connected in obsessive compulsive disorder[J]. Sci Rep，2021，11（1）：1354.
[40] CERAVOLO L，FRÜHHOLZ S，PIERCE J，et al. Basal ganglia and cerebellum contributions to vocal emotion processing as revealed by high-resolution fMRI[J]. Sci Rep，2021，11（1）：10645.
[41] LEGGIO M，OLIVITO G. Topography of the cerebellum in relation to social brain regions and emotions[J/OL]. Handb Clin Neurol，2018，154：71-84[2021-11-25]. https://doi.org/10.1016/B978-0-444-63956-1.00005-9.
[42] FERRARI C，OLDRATI V，GALLUCCI M，et al. The role of the cerebellum in explicit and incidental processing of facial emotional expressions：a study with transcranial magnetic stimulation[J/OL]. Neuroimage，2018，169：256-264[2021-11-25]. https://doi.org/10.1016/j.neuroimage.2017.12.026.
[43] VAN DEN BERG N S，HUITEMA R B，SPIKMAN J M，et al. Impairments in emotion recognition and risk-taking behavior after isolated，cerebellar stroke[J]. Cerebellum，2020，19（3）：419-425.
[44] THOMASSON M，SAJ A，BENIS D，et al. Cerebellar contribution to vocal emotion decoding：Insights from stroke and neuroimaging[J/OL]. Neuropsychologia，2019，132：107141[2021-11-25].https://doi.org/10.1016/j.neuropsychologia.2019.107141.