Research Progress on Lipoprotein(a) and Ischemic Stroke

doi:10.3969/j.issn.1673-5765.2025.06.014

Abstract

Abstract: Lipoprotein(a) [Lp(a)] is a highly heritable lipoprotein whose role in cardiovascular disease has been extensively studied. However, its association with ischemic stroke remains incompletely understood. This review summarizes the biological characteristics of Lp(a) and its variability across different ethnicities, geographic regions, age groups, and genders. It also explores the relationship between Lp(a) and genetic factors, highlighting its role in the onset and recurrence of ischemic stroke. Special emphasis is placed on the pathophysiological mechanisms of Lp(a) in atherosclerosis, inflammatory responses, and thrombogenesis. While conventional lipid-lowering therapies have shown limited efficacy in reducing Lp(a) levels, emerging strategies such as RNA-targeted therapies demonstrate promising potential in lowering Lp(a). These novel therapeutic strategies provide new targets and ideas for reducing stroke risk.

Key words: Lipoprotein(a); Ischemic stroke; Atherosclerosis; Oxidative stress; Inflammatory reaction

摘要： 脂蛋白（a）[lipoprotein(a)，Lp(a)]是一种具有高度遗传性的脂蛋白，其在心血管疾病中的作用已被广泛研究，但与缺血性卒中的关联尚未完全明确。本文回顾了Lp(a)的生物学特性，以及不同种族、地域、年龄和性别人群中Lp(a)水平的差异，并探讨了Lp(a)与遗传因素的关系，阐述了其在缺血性卒中的发生和复发中的作用，重点讨论了Lp(a)在动脉粥样硬化、炎症反应和血栓形成中的病理生理作用。目前，传统的降脂药物降低Lp(a)水平的作用有限，但RNA靶向治疗等新兴治疗策略显示出了降低Lp(a)水平的潜力。这些新兴的治疗策略为降低卒中风险提供了新的靶点与思路。

关键词: 脂蛋白（a）; 缺血性卒中; 动脉粥样硬化; 氧化应激; 炎症反应

CLC Number:

HE Xun, CHEN Xinyi, HU Jie, LI Jiaxuan, JIA Xinhui, WU Juncang. Research Progress on Lipoprotein(a) and Ischemic Stroke[J]. Chinese Journal of Stroke, 2025, 20(6): 775-780.

何讯, 陈心怡, 胡杰, 李佳璇, 贾新会, 吴君仓. 脂蛋白（a）与缺血性卒中的研究进展[J]. 中国卒中杂志, 2025, 20(6): 775-780.

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