Research Review on the Damage of Blood-Brain Barrier after Cerebral Hemorrhage

Abstract

Abstract:

Brain edema is one of the serious complications caused by hemorrhagic stroke, in which the vasogenic brain edema caused by blood-brain barrier damage is the main type of cerebral edema. At present, a number of studies have shown that there are various factors inducing bloodbrain barrier disruption after cerebral hemorrhage. For instance, thrombin, inflammatory mediators, matrix metalloproteinases, complement, hemoglobin breakdown products, aquaporin-4 and the interactions of them all play a significant role in this pathophysiological process.

Key words: Cerebral hemorrhage; Brain edema; Blood-brain barrier damage

摘要：

脑水肿是脑出血的严重并发症之一，其中血脑屏障损害导致的血管源性脑水肿是脑出血后脑水肿的主要类型。凝血酶、炎症因子、基质金属蛋白酶、补体、血红蛋白降解产物、水通道蛋白4 等以及这些因子间的相互作用都可能在脑出血后血脑屏障损害病理过程中发挥重要作用，本文对此做一综述。

关键词: 脑出血; 脑水肿; 血脑屏障损害

XU Nan, CAO Fei.. Research Review on the Damage of Blood-Brain Barrier after Cerebral Hemorrhage[J]. Chinese Journal of Stroke, 2015, 10(02): 181-186.

许楠，曹非. 脑出血后血脑屏障损害研究进展[J]. 中国卒中杂志, 2015, 10(02): 181-186.

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