Advances in Correlation between miRNA and Platelet Activity:a Novel and Potential Biomarker to Evaluate the Efficacy of Anti-platelet Therapy

Abstract

Abstract:

MicroRNA (miRNA) is a non-coding small RNA molecule, participating in regulating biologic activities, with a large quantity. MiRNAs have their specific expression in different processes related to platelet formation, mRNA regulation, protein synthesis and platelet activation. For instance, miRNA participates in regulating the biogenesis and differentiation of megakaryocytes and the pathway of platelet activation. Scientists pay a lot of efforts to figure out the relationship between miRNA and platelet reactivity, which points out a new possibility to evaluate the efficacy of anti-platelet therapy by using miRNA as a novel biomarker. This article is trying to review the studies about the relevance between miRNA and platelet reactivity.

Key words: MicroRNA; Platelet; Biomaker

摘要：

微RNA（microRNA，miRNA）是一种非编码的小RNA分子，在人体内含量丰富且参与许多生命活动的调控。MiRNA在血小板形成、mRNA调控、蛋白合成及激活各个过程均有特异性表达，如 miRNA参与调节巨核细胞的生成、分化和血小板激活通路等。许多研究试图进一步阐明miRNA与血小板活性的关系，为寻找评估抗血小板治疗效果的生物标志物提供了新的方向。

关键词: 微RNA; 血小板; 生物标志物

LIN Ze-Ming, LIU Xin-Tong.. Advances in Correlation between miRNA and Platelet Activity:a Novel and Potential Biomarker to Evaluate the Efficacy of Anti-platelet Therapy[J]. Chinese Journal of Stroke, 2015, 10(04): 331-335.

林泽明1，2，刘新通2. MiRNA与血小板活性的研究进展：一个新的评估抗血小板治疗效果的潜在生物标志物[J]. 中国卒中杂志, 2015, 10(04): 331-335.

References

1 Lee RC, Feinbaum RL, Ambros V, et al. The C.

elegans heterochronic gene lin-4 encodes small RNAs

with antisense complementarity to lin-14[J]. Cell,

1993, 75:843-854.

2 Bar tel DP. MicroRNAs:target recognition and

regulatory functions[J]. Cell, 2009, 136:215-233.

3 Mraz M, Pospisilova S. MicroRNAs in chronic

lymphocytic leukemia:From causality to associations

and back[J]. Expert Rev Hematol, 2012, 5:579-581.

4 Sepramaniam S, Tan JR, Tan KS, et al. Circulating

microRNAs as biomarkers of acute stroke[J]. Int J

Mol Sci, 2014, 15:1418-1432.

5 Hulsmans M, Holvoet P. MicroRNA-containing

microvesicles regulating inflammation in association

with atherosclerotic disease[J]. Cardiovasc Res, 2013,

100:7-18.

6 Landry P, Plante I, Ouellet DL, et al. Existence of

a microRNA pathway in anucleate platelets[J]. Nat

Struct Mol Biol, 2009, 16:961-966.

7 Michelson AD. How platelets work:platelet function and

dysfunction[J]. J Thromb Thrombolysis, 2003, 16:7-12.

8 Osman A, Falker K. Characterization of human

platelet microRNA by quantitative PCR coupled with

an annotation network for predicted target genes[J].

Platelets, 2011, 22:433-441.

9 Hunter MP, Ismail N, Zhang X, et al. Detection of

microRNA expression in human peripheral blood

microvesicles[J]. PLoS One, 2008, 3:e3694.

10 Chen X, Ba Y, Ma L, et al. Characterization of

microRNAs in serum:a novel class of biomarkers for

diagnosis of cancer and other diseases[J]. Cell Res,

2008, 18:997-1006.

11 Georgantas RW 3rd, Hildreth R, Morisot S, et al.

CD34+ hematopoietic stem-progenitor cell microRNA

expression and f unct ion:a ci rcuit diagram of

differentiation control[J]. Proc Natl Acad Sci USA,

2007, 104:2750-2755.

12 Lu J, Guo S, Ebert BL, et al. MicroRNA-mediated

control of cell fate in megakaryocyte-erythrocyte

progenitors[J]. Dev Cell, 2008, 14:843-853.

13 Girardot M, Pecquet C, Boukour S, et al. miR-28

is a thrombopoietin receptor targeting microRNA

detected in a fraction of myeloproliferative neoplasm

patient platelets[J]. Blood, 2010, 116:437-445.

14 Starczynowski DT, Kuchenbauer F, Argiropoulos

B, et al. Identification of miR-145 and miR-146a as

mediators of the 5q- syndrome phenotype[J]. Nat Med,

2010, 16:49-58.

15 Garzon R, Pichiorri F, Palumbo T, et al. MicroRNA

fingerprints during human megakaryocytopoiesis[J].

Proc Natl Acad Sci U S A, 2006, 103:5078-5083.

16 Edel s t e i n LC, McKen z ie SE, Shaw C, e t a l .

MicroRNAs in platelet production and activation[J]. J

Thromb Haemost, 2013, 11:340-350.

17 Kondkar AA, Bray MS, Leal SM, et al. VAMP8/

endobrevin is overexpressed in hyperreactive human

platelets:suggested role for platelet microRNA[J]. J

Thromb Haemost, 2010, 8:369-378.

18 Nagalla S, Shaw C, Kong X, et al. Platelet microRNAmRNA

coexpression profiles correlate with platelet

reactivity[J]. Blood, 2011, 117:5189-5197.

19 Gidlöf O, van der Brug M, Ohman J, et al. Platelets

activated during myocardial infarction release

functional miRNA, which can be taken up by

endothelial cells and regulate ICAM1 expression[J].

Blood, 2013, 121:3908-3917, S1-S26.

20 Shi R, Ge L, Zhou X, et al. Decreased platelet miR-

223 expression is associated with high on-clopidogrel

platelet reactivity[J]. Thromb Res, 2013, 131:508-513.

21 Edelstein LC, Simon LM, Montoya RT, et al. Racial

difference in human platelet PAR4 reactivity reflects

expression of PCTP and miR-376c[J]. Nat Med, 2013,

19:1609-1616.

22 Aradi D, Storey RF, Komócsi A, et al. Expert position

paper on the role of platelet function testing in patients

undergoing percutaneous coronary intervention[J].

Eur Heart J, 2014, 35:209-215.

23 Voora D1, Ginsburg GS, Akerblom A. Platelet RNA

as a novel biomarker for the response to antiplatelet

therapy[J]. Future Cardiol, 2014, 10:9-12.

24 Willeit P, Zampetaki A, Dudek K, et al. Circulating

mic roRNAs a s novel bioma rke r s for plat elet

activation[J]. Circ Res, 2013, 112:595-600.

25 Stratz C, Nührenberg TG, Binder H, et al. Micro-array

profiling exhibits remarkable intra-individual stability

of human platelet micro-RNA[J]. Thromb Haemost,

2012, 107:634-641.

[1]	GUO Shuaiwei, ZHANG Ya’nan, WANG Shuo. The Status and Significance of Platelet Function Tests in the Assessment of Hemostatic Function in Neurosurgery [J]. Chinese Journal of Stroke, 2024, 19(7): 848-853.
[2]	ZHANG Jiancun, WANG Xinxing, TONG Haibo. Research Progress on the Role of Platelet Activation in Acute Cerebral Infarction [J]. Chinese Journal of Stroke, 2024, 19(5): 579-585.
[3]	XIE Yaoyi, HUANG Yanju, FAN Min, CEN Huatao, LI Yanli, LU Miaozhi, LU Boan, WEI Rangfang, WU Zhiwu. Study on the Clinical Efficacy of Antiplatelet Therapy Guided by CYP2C19 Gene Detection in Ischemic Stroke Patients of Different Ethnic Groups [J]. Chinese Journal of Stroke, 2024, 19(10): 1119-1124.
[4]	HOU Yuting, LI Tong. A Case Report of Dual Antiplatelet Therapy for Acute Basilar Artery Occlusion Based on Rapid CYP2C19 Gene Detection [J]. Chinese Journal of Stroke, 2024, 19(10): 1125-1130.
[5]	FANG Xiaomeng, YUAN Qiaoling, WANG Shuo. Factors Related to the Deep Vein Thrombosis in Severe Spontaneous Intracerebral Hemorrhage Patients after Surgical Treatment [J]. Chinese Journal of Stroke, 2023, 18(8): 891-897.
[6]	. Chinese Stroke Association Guidelines for Clinical Management of Cerebrovascular Diseases (Second Edition) (Excerpt)——Chapter Four Clinical Management of Ischaemic Cerebrovascular Diseases [J]. Chinese Journal of Stroke, 2023, 18(8): 910-933.
[7]	LI Zhenhua, ZHANG Jiangang, XIE Weizheng, WANG Yu, LUO Xue, LIU Conghui, SUN Ke, YANG Qingcheng, GUO Yanping. Efficacy and Safety Study of Dual Antiplatelet Versus Alteplase in the Treatment of Acute Mild Non-Disabling Ischemic Stroke [J]. Chinese Journal of Stroke, 2023, 18(12): 1391-1396.
[8]	YU Wenlong, BAI Ruyu, YU Yanxue, GUO Xia, WU Lie. Real World Study on the Current Status and Influencing Factors of Antiplatelet Aggregation Drugs Use among People Aged 40 and above in Baotou, Inner Mongolia [J]. Chinese Journal of Stroke, 2023, 18(06): 651-659.
[9]	LI Zhenhua, LIU Zhu, HU Quanzhong. Progress in Drugs Therapy for Non-disabling Ischemic Cerebrovascular Events [J]. Chinese Journal of Stroke, 2022, 17(04): 407-412.
[10]	ZHANG Dongxue, ZOU Wei. Progress and Mechanism of Exosome in Ischemic Stroke [J]. Chinese Journal of Stroke, 2022, 17(04): 418-425.
[11]	LIU Zhong, LIU Yuanyuan, XU Shaofeng, GUO Wei, KANG Hai. Correlation Analysis of Systemic Immune-Inflammatory Index with Severity and Prognosis of Acute Ischemic Stroke [J]. Chinese Journal of Stroke, 2022, 17(03): 285-291.
[12]	ZHANG Junliang, HUANG Shuangfeng, XU Luyao, XIANG Wei, ZHANG Manman, LIANG Zhigang. Safety and Efficacy of Tirofiban in the Treatment of Mild to Moderate Non-Cardiogenic Ischemic Stroke Screened by MRI [J]. Chinese Journal of Stroke, 2022, 17(01): 66-72.
[13]	WANG Cong-Jie, LI Hong, ZHENG Li, LIU Shan, LU Hai-Li, CHEN Na, ZHANG Bin, ZHOU Heng. Efficacy of Dual Antiplatelet Therapy after Intravenous Thrombolysis in Patients with Mild Ischemic Stroke [J]. Chinese Journal of Stroke, 2021, 16(10): 1044-1049.
[14]	CHENG Yue, SHAO Teng-Fei, HUANG Li-Li, YANG Dan, XU Yun. Platelet Function Test in Predicting the Efficacy and Safety of Clopidogrel Secondary Prevention of Ischemic Stroke#br# [J]. Chinese Journal of Stroke, 2021, 16(06): 574-580.
[15]	YU Yi-Jiao, LIU Li, DU Juan, LI Wei, LIN Tian,LU Dong-Xu, CAI Yi-Ling. Clinical Features and Prognosis of Capsule Warning Syndrome [J]. Chinese Journal of Stroke, 2020, 15(12): 1317-1321.