Study Progress of Correlation between the Change of Mitochondrial Morphology and Acute Ischemic Stroke

Abstract

Abstract:

As a highly dynamic organelle in cells, mitochondria regulates its own quantity, morphology, and distribution through continual morphological changes of fission and fusion, thus indirectly determines the function and even the survival of tissue cells. This mechanism exists in various physiological and pathological procedures in mammalian animals’ cells. The pathogenesis and biology involving ischemic stroke includes calcium overload, oxidative stress, apoptosis et al, and these are relevant to the imbalance of mitochondrial fission and fusion. Hence, fully understanding and studying the correlation between mitochondrial fission and fusion and pathogenic factors of stroke could help to find new targets and methods for treating stroke.

Key words: Mitochondrial fission; Mitochondrial fusion; Stroke

摘要：

线粒体作为细胞内高度动态的细胞器，通过不断地分裂、融合等形态学变化来调节自身的数量、形态和分布，进而间接决定着组织细胞的功能甚至存亡，这一机制普遍存在于哺乳动物细胞内各种生理和病理过程中。缺血性卒中病理生理所涉及的钙超载、氧化应激和细胞凋亡等机制均与线粒体的分裂、融合失衡密不可分。因此，充分了解和研究线粒体融合、分裂与卒中致病因素之间的联系，将有利于找到治疗卒中的新靶点和新方法。

关键词: 线粒体分裂; 线粒体融合; 卒中

LI Yu-Chen, WANG Yong-Peng, DAI Jia-Xing, et al.. Study Progress of Correlation between the Change of Mitochondrial Morphology and Acute Ischemic Stroke[J]. Chinese Journal of Stroke, 2016, 11(02): 150-154.

李俞辰，王永朋，戴家兴，吴培，史怀璋. 线粒体形态学变化与急性缺血性卒中相关性的研究进展[J]. 中国卒中杂志, 2016, 11(02): 150-154.

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