Advances in Assessment of Treatment Effect of Statin for Atherosclerotic Diseases by High Resolution Magnetic Resonance Vessel Wall Imaging

Abstract

Abstract:

A number of studies demonstrated that high resolution magnetic resonance imaging (HRMRI) is accurately capable of evaluating atherosclerotic plaque burden and compositions qualitatively and quantitatively. In addition, HRMRI is an imaging technique with high reproducibility which has been largely utilized to monitor the treatment effect of statin for atherosclerotic diseases in clinical trials. This review will summarize the characteristics of HRMRI techniques, studies on reproducibility and clinical trials where this technique was used to monitor the treatment effect of statin for atherosclerotic diseases.

Key words: Magnetic resonance imaging, High resolution; Atherosclerotic plaque; Statin

摘要：

研究显示高分辨率磁共振成像技术能够准确定性和定量分析动脉粥样硬化斑块的负荷和成分特征，并具有高度可重复性，已被广泛应用于监测他汀类药物对动脉粥样硬化斑块治疗效果的临床试验中。本文将从高分辨率磁共振的成像方法、可重复性以及观察他汀类药物对动脉粥样硬化斑块疗效方面的研究进行综述，总结该技术在评估药物治疗动脉粥样硬化斑块疗效方面的应用价值。

关键词: 磁共振成像; 高分辨; 动脉粥样硬化斑块; 他汀

ZHUANG Zhong, PENG Xiao-Gang,ZHAO Xi-Hai. Advances in Assessment of Treatment Effect of Statin for Atherosclerotic Diseases by High Resolution Magnetic Resonance Vessel Wall Imaging[J]. Chinese Journal of Stroke, 2016, 11(03): 229-234.

庄仲，彭晓刚，赵锡海. 高分辨率磁共振管壁成像评估他汀类药物对动脉粥样硬化病变治疗效果的研究进展[J]. 中国卒中杂志, 2016, 11(03): 229-234.

References

1 管懋彬, 赵锡海, 杜芳, 等. 卒中相关的粥样硬化易损

斑块的病理与分布特点研究进展[J]. 中国卒中杂志,

2015, 10:243-247.

2 Gupta S. LDL cholesterol, statins and PC SK 9

inhibitors[J]. Indian Heart J, 2015, 67:419-424.

3 董莉, 于薇, 濮欣, 等. 高分辨MRI技术对动脉粥样硬

化斑块的评价[J]. 中国卒中杂志, 2014, 9:152-157.

4 王忠艳, 高培毅, 隋滨滨, 等. 颈动脉粥样硬化疾病的

高分辨磁共振成像研究进展[J]. 中国卒中杂志, 2014,

9:445-449.

5 Saam T, Kerwin WS, Chu B, et al. Sample size

calculat ion for clinical t r ials using magnet ic

resonance imaging for the quantitative assessment of

carotid atherosclerosis[J]. J Cardiovasc Magn Reson,

2005, 7:799-808.

6 Zhao X, Underhill HR, Yuan C, et al. Minimization

of MR contrast weightings for the comprehensive

evaluation of carotid atherosclerotic disease[J]. Invest

Radiol, 2010, 45:36-41.

7 Takaya N, Cai J, Ferguson MS, et al. Intra- and

interreader reproducibility of magnetic resonance

imaging for quantifying the lipid-rich necrotic core is

improved with gadolinium contrast enhancement[J]. J

Magn Reson Imaging, 2006, 24:203-210.

8 Touzé E, Toussaint JF, Coste J, et al. Reproducibility

of high-resolution MRI for the identification and

the quantification of carotid atherosclerotic plaque

components:consequences for prognosis studies and

therapeutic trials[J]. Stroke, 2007, 38:1812-1819.

9 Sa am T, Fe rg uson MS, Ya r nyk h VL, e t a l .

Quantitative evaluation of carotid plaque composition

by in vivo MRI[J]. Arterioscler Thromb Vasc Biol,

2005, 25:234-239.

10 Cai J, Hatsukami TS, Ferguson MS, et al. In vivo

quantitative measurement of intact f ibrous cap

and lipid-rich necrotic core size in atherosclerotic

carotid plaque:compar ison of high-resolution,

contrast-enhanced magnetic resonance imaging and

histology[J]. Circulation, 2005, 112:3437-3444.

11 Kerwin WS, O'Brien KD, Ferguson MS. Inflammation

in carotid atherosclerotic plaque:a dynamic contrastenhanced

MR imaging study[J]. Radiology, 2006,

241:459-468.

12 Kerwin WS, Oikawa M, Yuan C. MR imaging of

adventitial vasa vasorum in carotid atherosclerosis[J].

Magn Reson Med, 2008, 59:507-514.

13 EI Aidi H, Mani V, Weinshelbaum KB, et al. Crosssectional,

prospective study of MRI reproducibility in

the assessment of plaque burden of the carotid arteries

and aorta[J]. Nat Clin Pract Cardiovasc Med, 2009,6:219-228.

14 Varghese A, Crowe LA, Mohiaddin RH, et al.

Interstudy reproducibility of three-dimensional

volume-selective fast spin echo magnetic resonance

for quantifying carotid artery wall volume[J]. J Magn

Reson Imaging, 2005, 21:187-191.

15 Li F, Yarnykh VL, Hatsukami TS, et al. Scan-rescan

reproducibility of carotid atherosclerotic plaque

morphology and tissue composition measurements

using multicontrast MRI at 3T[J]. J Magn Reson

Imaging, 2010, 31:168-176.

16 Saam T, Yuan C, Chu B, et al. Predictors of carotid

atherosclerotic plaque progression as measured

by noninvasive magnetic resonance imaging[J].

Atherosclerosis, 2007, 194:e34-e42.

17 Underhill HR, Yuan C, Zhao XQ, et al. Effect of

rosuvastatin therapy on carotid plaque morphology

and composition in moderately hypercholesterolemic

patients:a high-resolution magnetic resonance imaging

trial[J]. Am Heart J, 2008, 155:584, e581-588.

18 Du R, Cai J, Zhao XQ, et al. Early decrease in

carotid plaque lipid content as assessed by magnetic

resonance imaging during treatment of rosuvastatin[J].

BMC Cardiovasc Disord, 2014, 14:83.

19 Lee JM, Robson MD, Yu LM, et al. Effects of highdose

modified-release nicotinic acid on atherosclerosis

and vascular function:a randomized, placebocontrolled,

magnetic resonance imaging study[J]. J

Am Coll Cardiol, 2009, 54:1787-1794.

20 Corti R, Fayad ZA, Fuster V, et al. Effects of lipidlowering

by simvastatin on human atherosclerotic

lesions:a longitudinal study by high-resolution,

noninvasive magnet ic resonance imaging[J ].

Circulation, 2001, 104:249-252.

21 Corti R, Fuster V, Fayad ZA, et al. Lipid lowering

by simvastat in induces regression of human

atherosclerotic lesions:two years' follow-up by highresolution

noninvasive magnetic resonance imaging[J].

Circulation, 2002, 106:2884-2887.

22 Sibley CT, Vavere AL, Got tlieb I, et al. MRImeasured

regression of carotid atherosclerosis induced

by statins with and without niacin in a randomised

controlled trial:the NIA plaque study[J]. Heart, 2013,

99:1675-1680.

23 Cor ti R, Fuster V, Fayad ZA, et al. Effects of

aggressive versus conventional lipid-lowering therapy

by simvastatin on human atherosclerotic lesions:a

prospective, randomized, double-blind trial with highresolution

magnetic resonance imaging[J]. J Am Coll

Cardiol, 2005, 46:106-112.

24 Yonemura A, Momiyama Y, Fayad ZA, et al. Effectof lipid-lowering therapy with atorvastatin on

atherosclerotic aortic plaques detected by noninvasive

magnetic resonance imaging[J]. J Am Coll Cardiol,

2005, 45:733-742.

25 Lee JM, Wiesmann F, Shirodaria C, et al. Early

changes in arterial structure and function following

statin initiation:quantification by magnetic resonance

imaging[J]. Atherosclerosis, 2008, 197:951-958.

26 Yonemura A, Momiyama Y, Fayad ZA, et al. Effect

of lipid-lowering therapy with atorvastatin on

atherosclerotic aortic plaques:a 2-year follow-up by

noninvasive MRI[J]. Eur J Cardiovasc Prev Rehabil,

2009, 16:222-228.

27 Migrino RQ, Bowers M, Harmann L, et al. Carotid

plaque regression fol lowing 6 -mont h stat in

therapy assessed by 3T cardiovascular magnetic

resonance:comparison with ultrasound intima media

thickness[J]. J Cardiovasc Magn Reson, 2011, 13:37.

28 Zhao XQ, Dong L, Hat sukami T, e t a l. MR

imaging of carotid plaque composition during

lipid-lowering therapy a prospective assessment

of effect and time course[J]. JACC Cardiovasc

Imaging, 2011, 4:977-986.

29 Lima JA, Desai MY, Steen H, et al. Statin-induced

cholesterol lowering and plaque regression after 6

months of magnetic resonance imaging-monitored

therapy[J]. Circulation, 2004, 110:2336-2341.

30 Gottlieb I, Agarwal S, Gautam S, et al. Aortic plaque

regression as determined by magnetic resonance

imaging with high-dose and low-dose statin therapy[J].

J Cardiovasc Med (Hagerstown), 2008, 9:700-706.

31 McGill HC Jr, Mc Mahan CA, Malcom GT, et

al. Effects of serum lipoproteins and smoking on

atherosclerosis in young men and women. The PDAY

Research Group. Pathobiological Determinants of

Atherosclerosis in Youth[J]. Arterioscler Thromb Vasc

Biol, 1997, 17:95-106.

32 Kawahara T, Nishikawa M, Furusawa T, et al. Effect

of atorvastatin and etidronate combination therapy on

regression of aortic atherosclerotic plaques evaluated

by magnetic resonance imaging[J]. J Atheroscler

Thromb, 2011, 18:384-395.

33 West AM, Anderson JD, Meyer CH, et al. The effect

of ezetimibe on peripheral arterial atherosclerosis

depends upon statin use at baseline[J]. Atherosclerosis,

2011, 218:156-162.

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