Abstract:

Objective To investigate the clinical features, thrombosis location, treatment and prognosis in patients with intracranial venous sinus thrombosis (CVST) associated with Behcet's disease (BD). Methods We performed a retrospective analysis of clinical data of 9 inpatients with CVST associated with BD in Beijing Tongren hospital of Capital Medical University from January 2014 to August 2016. Results Nine patients (age range 21-47 years, mean age 35.9 years) with CVST associated with BD were collected, of which 2 (22.2%) cases were male. The results of clinical features showed as follows: 1 acute onset (11.1%) and 8 chronic onset (88.9%); 4 headache (44.4%), 1 dizziness (11.1%), 3 paroxysmal amaurosis (33.3%), 5 decreased binocular vision (55.6%), 9 papilledema (100%), 3 diplopia (33.3%) and only 1 tinnitus (11.1%); 7 sigmoid sinus thrombosis (77.8%), 5 transverse sinus thrombosis (55.6%), 1 straight sinus thrombosis (11.1%), 1 inferior sagittal sinus thrombosis (11.1%) and 2 internal jugular vein thrombosis (22.2%); 4 cases involving only 1 sinus (44.4%) and 5 ones involving 2 and more than 2 sinus (55.6%). All patients were given with oral methazolamide 50 mg bid, and glucocorticoids impact treatment for 3 cases (33.3%), of which 1 case (11.1%) combined with warfarin anticoagulant therapy and the other two (22.2%) undergoing lumbar cistern - celiac bypass surgery. After follow-up of 1- 32 months, all patients obviously improved after treatment. Conclusion BD can cause CVST, one or more than one venous sinuses can be involved, and the possibility of BD should be excluded in CVST patients.

Key words: Behcet's disease; Cerebral venous sinus thrombosis

摘要：

目的 研究白塞病相关颅内静脉窦血栓形成（cerebral venous sinus thrombosis，CVST）的临床表现、血 栓好发部位、治疗及预后。 方法 回顾性分析2014年1月-2016年8月于首都医科大学附属北京同仁医院神经内科住院的白塞病 相关CVST患者的临床资料。 结果 共收集白塞病相关CVST患者9例,其中男性2例（22.2%），女性7例（77.8%），年龄21～47岁，中 位数是35.9岁；急性起病1例（11.1%），慢性起病8例（88.9%）；头痛4例（44.4%）、头晕1例（11.1%）、 阵发性黑蒙3例（33.3%）、双眼视力下降5例（55.6%）、视盘水肿9例（100%）、复视3例（33.3%）、耳 鸣1例（11.1%）；乙状窦血栓形成7例（77.8%）、横窦血栓5例（55.6%）、直窦血栓1例（11.1%）、下矢状 窦血栓1例（11.1%）、颈内静脉血栓2例（22.2%）；仅1处静脉窦受累的4例（44.4%），同时有2处及2处 以上静脉窦受累的5例（55.6%）；所有患者均予醋甲唑胺50 mg 2次/日口服，3例予糖皮质激素冲击 治疗，其中1例合并华法林抗凝治疗、2例进行了腰大池-腹腔分流手术。随访1～32个月,所有患者治疗 后均好转。 结论 白塞病可引起颅内静脉窦血栓形成，可累及单处或多处静脉窦，CVST患者需除外白塞病可能。

关键词: 白塞病; 颅内静脉窦血栓形成