Progress of Correlation of Migraine and Ischemic Stroke

doi:10.3969/j.issn.1673-5765.2018.12.017

Abstract

Abstract:

The previous studies have demonstrated migraine may be a risk factor of ischemic stroke. Neuroimaging studies also suggested that migraine is associated with brain structural abnormality. However, the specific pathophysiological mechanism of migraine in ischemic cerebrovascular diseases is still unclear. The possible etiology and pathogenesis include that external factors (such as migraine drugs and lifestyle etc.), endothelial dysfunction and coagulation abnormalities, cortical spreading depression, etc. This article reviewed that the advance in epidemiology, neuroimaging and genetics of migraine increasing the risk of ischemic stroke, and the possible pathophysiologic mechanism involved.

Key words: Migraine; Ischemic stroke; Pathophysiologic mechanism; Cortical spreading depression

摘要：

流行病学数据已证实偏头痛可能增加缺血性卒中风险，神经影像学研究也显示偏头痛与脑结构异常有关。但联系偏头痛与缺血性脑疾病的可能病理生理机制尚不完全清楚，可能的假说包括药物和生活方式等外界因素影响、内皮功能障碍和凝血异常、皮层扩散抑制等。本文就近年来偏头痛增加缺血性卒中风险的流行病学、神经影像学和遗传学的证据，以及目前涉及的可能的主要病理生理机制给予综述。

关键词: 偏头痛; 缺血性卒中; 病理生理机制; 皮层扩散抑制

CUI Shu-Hui, CHEN Ning, HE Li. Progress of Correlation of Migraine and Ischemic Stroke[J]. Chinese Journal of Stroke, 2018, 13(12): 1309-1315.

崔淑慧, 陈宁, 何俐. 偏头痛增加缺血性卒中风险的研究进展[J]. 中国卒中杂志, 2018, 13(12): 1309-1315.

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