Progress of Immunomodulation Therapy for Ischemic Stroke

doi:10.3969/j.issn.1673-5765.2020.01.009

Abstract

Abstract:

The immune system plays an important role in the pathological process of ischemic stroke through innate and adaptive immune responses. After ischemic stroke onset, destructive cytokines released by activated immune cells can damage vascular endothelium, blood-brain barrier and neurons. Then adaptive immune response is activated by the combination of lymphocytes and specific antigen and aggravates neuron injury. On the other hand, there are protective responses in the body, neuron injury can be alleviated by removing necrotic tissue, releasing protective cytokines and regulating immunosuppression. Immunomodulation therapy provides a new direction for the treatment of stroke. Immunoregulatory drugs such as fingomod, minocycline and natazumab have shown good efficacy in animal model experiments and clinical studies of ischemic stroke. This article reviews the research progress of immunomodulation therapy for ischemic stroke.

Key words: Stroke; Therapy; Immunomodulation

摘要：

在缺血性卒中的病理过程中，免疫系统通过固有免疫反应和适应性免疫反应发挥着重要的作用。缺血性卒中发生后，一方面通过激活的免疫细胞释放破坏性细胞因子，损伤血管内皮，破坏血脑屏障和神经元，并在淋巴细胞与特异性抗原结合后诱发适应性免疫反应，加重神经元损伤；另一方面通过清除坏死组织，释放保护性细胞因子，调节免疫抑制等途径减轻神经元损伤。免疫调节治疗为卒中的治疗提供了一个新的方向，以芬戈莫德、米诺环素、那他珠单抗等药物为代表的免疫调节药物在缺血性卒中动物模型实验和临床研究中都呈现出较好的疗效。本文就缺血性卒中免疫调节治疗的研究进展做一综述。

关键词: 卒中; 治疗; 免疫调节

ZOU Ming. Progress of Immunomodulation Therapy for Ischemic Stroke[J]. Chinese Journal of Stroke, 2020, 15(01): 57-62.

邹明. 缺血性卒中免疫调节治疗的研究进展[J]. 中国卒中杂志, 2020, 15(01): 57-62.

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