Abstract:

Objective To observe the effects of butylphthalide injection on cerebral blood flow in patients with acute cerebral infarction by MRI 3-dimensional arterial spin labeling (3D-ASL) scanning. Methods 60 patients with acute ischemic stroke due to non-major artery stenosis or occulsion were included in this study. All included patients were randomly divided into observation group (30 cases) and control group (30 cases).The patients in control group were given conventional treatment, and the ones in observation group were given butylphthalide injection added on conventional treatment. The treatment course was 14 days. The changes in relative cerebral blood flow (rCBF) were measured by 3D-ASL before and after treatment. Results The difference in rCBF between the observation group and control group was not statistically significant before treatment, and the rCBF in observation group was higher than that in control group after treatment (0.97±0.45 vs 0.35±0.15, P =0.003). Conclusions Butylphthalide can improve the cerebral blood flow perfusion in infarct area.

Key words: Cerebral infarction; Sodium butylphthalide chloride injection; Magnetic resonance imaging; Three-dimensional arterial spin labeling

摘要：

目的 采用MRI 三维动脉自旋标记（3-dimensional arterial spin labeling，3D-ASL）技术观察急性缺血 性卒中患者使用丁苯酞注射液对脑血流灌注的影响。 方法 纳入60例非大动脉狭窄或闭塞性急性缺血性卒中患者，随机分为观察组（30例）和对照组 （30例）。对照组采用常规治疗，观察组在对照组治疗基础上加用丁苯酞注射液，疗程为14 d。治疗前 后均进行头颅3D-ASL检查来测量梗死灶相对脑血流量（relative cerebral blood flow，rCBF）的变化。 结果 观察组和对照组治疗前rCBF差异无统计学意义，治疗后观察组rCBF高于对照组（0.97±0.45 vs 0.35±0.15，P =0.003）。 结论 丁苯酞注射液可以提高急性缺血性卒中患者梗死病灶区域的脑血流灌注水平。

关键词: 缺血性卒中; 丁苯酞氯化钠注射液; 磁共振成像; 三维动脉自旋标记技术