Abstract: Objective To analyze the influence of coronavirus disease 2019 (COVID-19) on cognitive function and psychological state of stroke inpatients. Methods In this retrospective study, inpatients with stroke admitted to Department of Neurology of Beijing Tiantan Hospital, Capital Medical University during COVID-19 pandemic from January 1 to April 30, 2020 were included as the observation group, and inpatients with stroke in the same department from January 1 to April 30, 2019 were included as the control group. MoCA and the 9-item patient health questionnaire (PHQ-9) scale to screen depression were used in the patients of both groups. The 2-item patient health questionnaire (PHQ-2) was used in all the included patients to screen depression at 3-month follow up. Results A total of 106 patients in observation group and 180 in control group were included in this study. Compared to control group, the proportion of patients with a history of atrial fibrillation

in observation group was higher (13.21% vs 4.44%, P =0.01) and the proportion of patients with a

history of myocardial infarction was lower (0 vs 5.56%, P =0.01). There was no statistical difference in MoCA score between the two groups, but PHQ-9 score of the observation group [13 (11-16) vs 7 (4-11), P <0.01] was higher. With PHQ-9 score ≥10 points as a criterion for diagnosing depression, the proportion of post-stroke depression patients in observation group was higher than that in control group (39.62% vs 35.00%, P <0.01). At 3-month follow-up, PHQ-2 score in observation group was also higher than that in control group [4 (3-5) vs 3 (2-5), P <0.01]. Conclusions Inpatients with stroke were more prone to become depressed during the COVID-19 epidemic, and appropriate psychological interventions should be given to improve the patients’ mental health.

Key words: Coronavirus disease 2019; Stroke; Cognitive function; Depression

摘要： 目的 分析新型冠状病毒肺炎（coronavirus disease 2019，COVID-19）疫情对卒中住院患者认知功能 和心理状态的影响。 方法 本研究回顾性纳入2020年1月1日-4月30日COVID-19疫情期间于首都医科大学附属北京天坛 医院神经内科住院的卒中患者作为观察组，以2019年1月1日-4月30日同科室住院的卒中患者为对照 组。比较两组患者住院期间MoCA和9项患者健康问卷（patient health questionnare-9，PHQ-9）抑郁症筛 查量表评分的差异；比较两组患者3个月随访时的抑郁症筛查量表-2项患者健康问卷（Patient Health Questionnare-2，PHQ-2）评分的差异。 结果 本研究共纳入观察组患者106例，对照组患者180例。观察组患者既往心房颤动病史比例较 高（13.21% vs 4.44%，P＝0.01）、既往心肌梗死病史比例较低（0 vs 5.56%，P＝0.01）。住院期间，两 组患者MoCA评分差异无统计学意义，观察组PHQ-9抑郁症筛查量表得分[13（11～16）vs 7（4～11），P ＜0.01]显著高于对照组。以PHQ-9评分≥10分作为诊断抑郁情绪的界值，观察组出现卒中后抑郁情 绪的比例高于对照组（39.62% vs 35.00%，P＜0.01）。3个月随访时，观察组PHQ-2评分高于对照组[4 （3～5）vs 3（2～4），P＜0.01]。 结论 COVID-19疫情时期卒中住院患者更易出现抑郁情绪，应给予相应的心理干预，以改善患者心 理健康状况。

关键词: 新型冠状病毒肺炎; 卒中; 认知功能; 抑郁