Research Progress on the Role of Sphingosine 1-Phosphate in Ischemic Stroke

doi:10.3969/j.issn.1673-5765.2023.07.014

Abstract

Abstract: After cerebral ischemia and necrosis, inflammatory factors are released to induce inflammatory response, and glial cells are activated to participate in the cascade immune response after ischemia injury. The metabolism of sphingosine 1-phosphate (S1P) is correlated with ischemic stroke. Glial cells up-regulate the expression of sphingosine 1-phosphate receptors (S1PRs) in the inflammatory state. S1PRs sends S1P signal to participate in the up-regulation of inflammatory mediators in the brain tissue. The combination of S1P and S1PRs is involved in the inflammatory and immune response after ischemic stroke, endothelial cell adhesion and angiogenesis, and the improvement of blood-brain barrier function. This article reviews the metabolic and physiological functions of S1P and its potential mechanism of improving ischemic stroke after binding to S1PRs, in order to provide a strong evidence for finding new drug targets related to ischemic stroke.

Key words: Sphingosine 1-phosphate; Ischemic stroke; Sphingosine; Stroke

摘要： 脑组织缺血坏死后释放出炎性因子诱发炎症反应，并激活神经胶质细胞参与损伤后的级联免疫反应，1-磷酸鞘氨醇（sphingosine 1-phosphate，S1P）代谢与缺血性卒中具有相关性，神经胶质细胞在炎症状态下上调1-磷酸鞘氨醇受体（sphingosine 1-phosphate receptors，S1PRs）的表达，S1PRs发出S1P信号参与脑组织中炎症介质的上调，S1P与S1PRs结合参与缺血性卒中后炎症和免疫反应、内皮细胞的黏附和血管生成以及改善血脑屏障功能。本文就S1P的代谢和生理功能及其与S1PRs结合后改善缺血性卒中的潜在机制进行综述，以期为寻找缺血性卒中相关药物新靶点提供依据。

关键词: 1-磷酸鞘氨醇; 缺血性卒中; 鞘氨醇; 卒中

LI Ping, FU Shengqi. Research Progress on the Role of Sphingosine 1-Phosphate in Ischemic Stroke[J]. Chinese Journal of Stroke, 2023, 18(07): 829-836.

李萍, 付胜奇. 1-磷酸鞘氨醇在缺血性卒中中的作用研究进展[J]. 中国卒中杂志, 2023, 18(07): 829-836.

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