Objective To investigate hemodynamic variation of intracranial arteries in hemodialysis patients during interdialytic phases.
Methods A case-control study was performed with 30 hemodialysis patients and 28 age-gender-matched clinical patients with normal renal function as control group. Both of them received transcranial duplex sonography (TCD) examination, including bilateral mean blood flow velocity (MV) of anterior cerebral artery (ACA), middle cerebral artery (MCA), posterior cerebral artery (PCA) and basilar artery (BA), resistance index (RI), pulsatility index(PI). Then Logistic regression analysis was applied to test risk factors of the hemodynamics of intracranial arteries.
Results The MV values in ACA, MCA, PCA and BA were (67.3±12.7)cm/s (P=0.03), (76.5±13.4)cm/s (P=0.04), (66.7±12.5)cm/s (P=0.04), (51.3±10.7)cm/s (P=0.03), respectively, which were significantly increased compared with those in control groups. The Logistic analysis showed that anemia was associated with the increased of MV in each of arteries, the odds ratio (OR) in ACA, MCA, PCA and BA were 1.2(1.1~2.9), 2.2(1.8~3.6), 1.9(1.7~3.2), 1.6(1.5~3.1), respectively; hypertension was also associated with the increased of MV in all intracranial arteries, the OR (95% CI) were 2.4(1.9~3.9), 2.9(1.7~4.2), 2.1(1.7~3.9), 2.6(1.8~3.1), respectively.
Conclusion The MV of intracranial arteries increases significantly in hemodialysis patients during interdialytic phase, which is associated with anemia and hypertension in these patients.
