Objective To examine the relationship of the level of plasma Hcy with renal dysfunction in
patients with leukoaraiosis (LA).
Methods According to the renal function, the patients were divided into renal dysfunction group
(n =112) and normal control group (n =74). Demographic information such as sex, age, and past
history were collected. The blood Cr, BUN, UA, Hcy, HbA1c, TC, LDL-C were measured. The
degree of LA was measured by Fazekas scale according to MRI imaging.
Results A total of 186 patients with LA were enrolled in this study. (1) The BUN (P =0.001), Cr
(P =0.000), UA (P =0.000) and Hcy levels in renal dysfunction group were significantly higher than
those in control group (P =0.000), and the Fazekas score was significantly higher than that of control
group (P =0.04). (2) The correlation analysis showed that plasma Hcy level were positively correlated
with the Fazekas score (r =0.202, P =0.027), the level of blood Cr (r =0.458, P =0.000), UA (r =0.229,
P =0.010) and BUN (r =0.178, P =0.046). (3) Multivariate logistic regression analysis showed that
plasma Hcy level (OR 4.165, 95%CI 1.138-15.249, P =0.031) was an independent risk factor of renal
dysfunction in patients with LA .
Conclusions Plasma Hcy level may be an independent risk factor of renal dysfunction in patients with
LA, and renal dysfunction may be involved in the development of LA by affecting blood Hcy level.
