Table of Content

20 June 2021, Volume 16 Issue 06

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Progress of Stent-assisted Coiling of Intracranial Aneurysms

CAO Yi

2021, 16(06):  533-536.  DOI: 10.3969/j.issn.1673-5765.2021.06.001

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Endovascular Treatment of Intracranial Aneurysms

CAO Yi

2021, 16(06):  537-537. 

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Progress of Flow Diverter Devices in Treatment of Large or Giant Intracranial Aneurysms

HU Hang, CAO Yi, BAO Juan

2021, 16(06):  538-543.  DOI: 10.3969/j.issn.1673-5765.2021.06.002

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With the development of neurointervention techniques, material science and computer simulation technology, and the application of new generation of flow diverter (FD) devices, these new techniques and materials have changed the direction of treatment for large or giant intracranial aneurysms (LIA/GIA) from the previous treatment for aneurysms to the reconstruction of parent artery. At present, a variety of flow diverter devices have been applied in clinical practice at home and abroad, and their safety and effectiveness have been proved. This article mainly reviewed the clinical feature of LIA or GIA, the mechanism of FD in the treatment of LIA or GIA, current status of clinical application and complications of FD therapy.

Analysis of Stent-assisted Coil Embolization of Wide-necked Anterior Communicating Artery Aneurysms

CHEN Bo-Yu, CAO Yi, BAO Juan, YANG Yong-Tao, JING Rui, LI Yun-Fei, HU Jia-Yi, ZHAO Qing

2021, 16(06):  544-550.  DOI: 10.3969/j.issn.1673-5765.2021.06.003

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Objective To analyze the safety and efficacy of stent-assisted coil embolization of wide-necked anterior communicating artery aneurysms (ACoAA). Methods The patients with wide-necked ACoAA diagnosed by DSA who were treated by stentassisted coil embolization at Department of Cerebrovascular Disease, The Second Affiliated Hospital, Kunming Medical University between July 2016 and July 2020 were included in this retrospective analysis. The clinical relevant data of all patients were collected and analyzed to evaluate the technical feasibility (modified Raymond-Roy occlusion classification at end of precedure), periprocedural complications, aneurysm occlusion (6-month DSA imaging followup), and clinical outcome (mRS score at 6-month follow-up, good prognosis was defined as a mRS score of 0-2). Results A total of 32 patients were included, including 10 ones with unruptured aneurysms and 22 with ruptured aneurysms, of which 10 cases (45.45%) with ruptured aneurysms for Hunt-Hess grade 3-4. The median maximum aneurysm diameter of 32 aneurysms were 4.98 (3.00-8.13) mm. For aneurysm occlusion evaluation, Raymond grade I occlusion (near-complete) was obtained in 28 cases (87.50%). Intraprocedural in-stent thrombosis occurred in 3 cases (9.38%), postprocedural aneurysm rebleeding occurred in 1 case (3.13%), and 2 cases (6.25%) died from postprocedural rebleeding and in-stent thrombosis, respectively. The 6-month DSA follow-up showed no recurrence of aneurysms. 26 cases (81.30%) had a good prognosis at 6-month follow-up. Conclusions The individualized stent-assisted coil embolization of wide-necked ACoAA can be effective and safe.



Analysis of the Efficacy of Endovascular Treatment of Paraclinoid Unruptured Intracranial Aneurysms

HE Yi-Xuan, WANG Bing, DENG Jian-Ping, YU Jia, ZHAO Zhen-Wei

2021, 16(06):  551-555.  DOI: 10.3969/j.issn.1673-5765.2021.06.004

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Objective To evaluate the safety and efficacy of endovascular treatment of paraclinoid unruptured intracranial aneurysms (UIA). Methods Patients with paraclinoid UIA admitted to Department of Neurosurgery of Tangdu Hospital, Air Force Military Medical University from January 2017 to December 2019 were included in this retrospective analysis. The collected data included the baseline data, imaging data, the results of aneurysms embolization, periprocedural complications and the proportion of poor prognosis (mRS>2 points). The factors associated with postprocedural recurrence of aneurysms were analyzed. Results A total of 176 patients were included in this analysis, with a mean age of 54.7±9.6 years (aged 23-74 years) and 32 males (18.2%). Among 184 aneurysms, Raymond Ⅰ 151 (82.1%), Raymond Ⅱ 31 (16.8%) and Raymond Ⅲ 2 (1.1%). Periprocedural complications occurred in 11 cases (6.3%); 5 cases (3.3%) of the 151 patients with clinical follow-up had poor prognosis; 8 cases (7.0%) of the 114 patients with imaging follow-up had aneurysms recurrence. Univariate analysis showed that incomplete embolization was associated with aneurysms recurrence (P =0.004). Conclusions Endovascular treatment of paraclinoid UIA was generally safe and effective, and complete embolization of paraclinoid UIA should be attempted.



Tirofiban for Periprocedural In-stent Thrombosis during Stent-assisted Coiling of Intracranial Aneurysms:A Single Center Experience#br#

XU Wei-Dong, CHEN Ru-Dong, LI Hua, ZENG Ling-Cheng, YANG Hong-Kuan, YU Jia-Sheng

2021, 16(06):  556-560.  DOI: 10.3969/j.issn.1673-5765.2021.06.005

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Objective To investigate the efficacy and safety of tirofiban in treatment of periprocedural in-stent thrombosis during stent-assisted coiling of intracranial aneurysms. Methods This retrospective analysis enrolled the patients with perioprocedural in-stent thrombosis during stent-assisted coiling for intracranial aneurysms at Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology from June 2018 to December 2020. The clinical data of all the patients were analyzed to evaluate the efficacy and safety of tirofiban for periprocedural thrombosis, and the assessment indexes included the thrombus dissolution rate, periprocedural bleeding and mRS score at discharge. Results Of 177 patients who underwent stent-assisted coil embolization, 12 cases (6.8%) had periprocedural thrombotic events, with a median age of 56.5 years and 11 (91.7%) females, including 10 cases (83.3%) with anterior circulation aneurysms and 2 cases (16.7%) with posterior circulation aneurysms, all of which were unruptured aneurysms. Laser sculpting stents were used in 4 cases (33.3%) and braided stents were used in 8 cases (66.7%). Intraprocedural thrombotic events occurred in 9 cases (85.0%), and postprocedural thrombotic events occurred in 3 cases (15.0%). After the application of tirofiban, the thrombus was successfully dissolved in all 12 patients. Only one patient had an intracerebral hemorrhage after using tirofiban, and this patient had a poor prognosis (mRS 4 points) at discharge, and the remaining 11 patients (91.7%) had no complication and they all had a good prognosis (all mRS 0 point). Conclusions The application of tirofiban is a safe and effective treatment for periprocedural instent thrombosis during stent-assisted coiling of intracranial aneurysms.



Effect of Collateral Circulation on Long-term Prognosis in Non-acute Intracranial Anterior Circulation Large Artery Occlusion Patients Treated with Conventional Medicine#br#

LI Tao, ZHAO Li-Li, WU Yu-Lun, WANG Xiao-Ya, WANG He-Ying, JIAN Ya-Ting, JIANG Yu, DANG Mei-Juan, LI Ye, ZHANG Yi-Heng, ZHANG Lei, WANG Hu-Qing, ZHANG Ru, ZHANG Gui-Lian

2021, 16(06):  561-566.  DOI: 10.3969/j.issn.1673-5765.2021.06.006

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Objective To analyze the effect of collateral circulation on long-term prognosis in patients with anterior circulation large vessel occlusion. Methods Patients with non-acute unilateral internal carotid artery (ICA) / middle cerebral artery (MCA) occlusion and receiving aggressive medicine treatment who were admitted in the Second Affiliated Hospital of Xi'an Jiaotong University were enrolled in this retrospective study. The collateral circulation of all the patients were evaluated using American Society of Interventional Neuroradiology (ASITN) / Society of Interventional Radiology (SIR) collateral flow grading system. All the patients were divided into good collateral circulation group (Grade 0-2) and poor collateral circulation group (Grade 3-4). Kaplan-Meier survival curve analysis were used to compare cumulative incidence of recurrent ischemic vascular events and relevant vascular death between

the two groups. Cox regression analysis was used to determine the risk factors for recurrence of

ischemic vascular events. Results Of 302 patients, 222 were in good collateral group and 80 were in poor collateral group. The follow-up time ranged from 2 to 8 years, and the medium follow-up time was 4.0 (3.0-5.0) years. During follow-up, 45 patients (14.9%) had recurrent ischemic vascular events. The 2-year cumulative incidence of ischemic vascular events and mortality in good collateral circulation group were lower than that in poor collateral circulation group (vascular events: 14.3% vs 23.8%, P =0.046; mortality: 4.4% vs 10%, P =0.006, respectively). Cox regression analysis showed that age ≥60 years, history of coronary heart disease, poor collateral circulation (RR 1.86, 95%CI 1.03-4.53, P =0.041), and mRS score >2 points at discharge (RR 3.43, 95%CI 1.69-6.96, P =0.001) were independent risk factors for recurrent ischemic vascular events. Conclusions Patients with non-acute symptomatic ICA/MCA occlusion, especially those with poor collateral circulation, had a high risk of ischemic vascular events recurrence and vascular death within 2 years, even after aggressive medicine treatment. Age ≥60 years, history of coronary heart disease, poor collateral circulation and mRS score >2 points at discharge were independent risk factors for recurrence of ischemic vascular events.



Exploring the Construction Model of Multi-center Clinical Research Biobank for Cerebrovascular Disease in China#br#

LIN Jin-Xi, LIANG Xian-Hong, LI Shang-Zhi, LIU Li, MENG Xia, LI Zi-Xiao, WANG Yong-Jun

2021, 16(06):  567-573.  DOI: 10.3969/j.issn.1673-5765.2021.06.007

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Objective To explore how to construct the biobank for Chinese cerebrovascular disease (CVD) multi-center clinical research and the biobank management model, to improve the quality of CVD biological samples and promote resource sharing. Methods Based on the standardization idea of international standardization organizations, referring to the experience of multi-center clinical trial projects, combined with the actual needs of CVD special-disease cohort study, Chinese multi-center CVD clinical research biobank was constructed, and the biobank management model was developed. The management process of multi-center clinical research biobank was developed from the perspectives of sites, facilities and equipment, operation procedure, quality control, etc. Results According to the construction standards proposed in this article, Tiantan Cerebrovascular Disease Biobank has been established, and the management system of biological samples platform for multi-center CVD clinical research was built. Conclusions Tiantan Cerebrovascular Disease Biobank realized centers unified, standardized, realtime, the whole process quality management for multi-center clinical research, which can guarantee the quality of biological samples in multiple centers, and provide high quality biological sample

resources for precise medicine research, such as CVD screening, early warning, diagnosis and

intervention, etc.



Platelet Function Test in Predicting the Efficacy and Safety of Clopidogrel Secondary Prevention of Ischemic Stroke#br#

CHENG Yue, SHAO Teng-Fei, HUANG Li-Li, YANG Dan, XU Yun

2021, 16(06):  574-580.  DOI: 10.3969/j.issn.1673-5765.2021.06.008

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Objective To evaluate the value of light transmittance aggregometry (LTA), thromboelastography (TEG) and platelet function analyzer (PFA) in predicting clinical outcome of the patients with minor ischemic stroke. Methods Acute minor ischemic stroke inpatients receiving clopidogrel for secondary prevention of ischemic stroke between May 2017 and February 2019 were consecutively collected. Residual platelet reactivity of five days after clopidogrel treatment was analyzed using LTA, TEG, and PFA. The main efficacy endpoint was recurrence of ischemic stroke, and the safety endpoint was antiplatelet therapy related bleeding. The platelet reactivity and CYP2C19 genotype were compared between recurrence group and non-recurrence group and between bleeding and non-bleeding group. Receiver operating characteristic curve analysis was used to evaluate the value of platelet function test in predicting ischemic stroke recurrence.

Results A total of 76 patients were included, and the median follow-up time was 13 months. 5

patients (6.58%) had recurrent ischemic stroke, and bleeding events occurred in 17 patients (22.37%). The on-treatment platelet reactivity by LTA [82.00% (76.00%-85.00%) vs 44.00% (27.00%-60.50%), P =0.005] and TEG [43.30% (34.40%-61.60%) vs 69.00% (52.45%-86.10%), P =0.032] analysis in patients with recurrent stroke was higher than that in patients without recurrent stroke. The area under the curve (AUC) was 0.88 (95%CI 0.73-1.00) for LTA and 0.79 (95%CI 0.61-0.97) for TEG. However, CYP2C19 genotype and PFA results were not associated with ischemic stroke recurrence. The platelet function results by the three tests were not associated with bleeding events. Conclusions LTA and TEG tests may predict 1-year recurrent ischemic stroke events in clopidogrel secondary prevention, while PFA test showed poor predictive power. None of the tests were effective in predicting antiplatelet related bleeding events.



Risk Factors for Hydrocephalus in Children with Intracerebral Hemorrhage

CHANG He-Sheng, ZHANG Gui-Tao, WANG Yu-Bo, YU Miao-Xin, WANG Xiao-Yu, XU Juan-Yu, DENG Ya-Xian, LIU Gai-Fen, ZHAO Cheng-Song, QIN Xuan-Guang

2021, 16(06):  581-584.  DOI: 10.3969/j.issn.1673-5765.2021.06.009

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Objective To investigate the risk factors of hydrocephalus in children with cerebral hemorrhage, and to provide evidence for early identification of the children at high risk of hydrocephalus. Methods This retrospective study enrolled the data of hospitalized children with intracerebral hemorrhage or nontraumatic intracranial hemorrhage from 4 hospitals in Beijing in 2018. The baseline information were collected, including demographics, type of medical insurance, imaging results, complications during hospitalization, length of stay and total cost of hospitalization. Multivariate logistic regression analysis was used to analyze the risk factors of cerebral hemorrhage combined with hydrocephalus in children. Results A total of 140 children with intracerebral hemorrhage were included in the study, of which 17 cases (12.14%) had hydrocephalus during hospitalization. The patients with hydrocephalus had higher incidence of intraventricular hemorrhage (64.71% vs 20.33%, P <0.01) and pulmonary infection during hospitalization (41.18% vs 4.88%, P <0.01), compared with patients without hydrocephalus. Multivariate logistic regression analysis showed that younger age (OR 1.15, 95%CI

1.01-1.31, P =0.03) and intraventricular hemorrhage (OR 9.77, 95%CI 2.99-31.87, P <0.01) were

Objective To investigate the risk factors of hydrocephalus in children with cerebral hemorrhage, and to provide evidence for early identification of the children at high risk of hydrocephalus. Methods This retrospective study enrolled the data of hospitalized children with intracerebral hemorrhage or nontraumatic intracranial hemorrhage from 4 hospitals in Beijing in 2018. The baseline information were collected, including demographics, type of medical insurance, imaging results, complications during hospitalization, length of stay and total cost of hospitalization. Multivariate logistic regression analysis was used to analyze the risk factors of cerebral hemorrhage combined with hydrocephalus in children. Results A total of 140 children with intracerebral hemorrhage were included in the study, of which 17 cases (12.14%) had hydrocephalus during hospitalization. The patients with hydrocephalus had higher incidence of intraventricular hemorrhage (64.71% vs 20.33%, P <0.01) and pulmonary infection during hospitalization (41.18% vs 4.88%, P <0.01), compared with patients without hydrocephalus. Multivariate logistic regression analysis showed that younger age (OR 1.15, 95%CI 1.01-1.31, P =0.03) and intraventricular hemorrhage (OR 9.77, 95%CI 2.99-31.87, P <0.01) were



Comparison of Efficacy of ADAPT Technology and Stent-retriever Thrombectomy in Acute Intracranial Vessel#br# Occlusion#br#

JIAN Neng-Ri, ZHOU Xuan, LUO Yi-Chun, GAO Rong-Hui, HU Hang-Jia, HU Fa-Yun

2021, 16(06):  585-589.  DOI: 10.3969/j.issn.1673-5765.2021.06.010

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Objective To compare the efficacy and safety of a direct aspiration first-pass thrombectomy (ADAPT) technology and stent-retriever thrombectomy for acute intracranial vessel occlusion. Methods This retrospective study enrolled the consecutive patients with acute intracranial vessel occlusion admitted to West China Hospital from March to December 2019, and all the patients were divided into stent group and ADAPT group according to surgical method. Successful recanalization was defined as mTICI 2b or 3 at end of procedure. Treatment technology related indexes included puncture to recanalization time, the percentage of one-time and total complete recanalization, the time of one-time complete recanalization. The efficacy indexes was the percentage of having a good prognosis (90-day mRS≤2 points), safety index included intraoperative thrombus escape and symptomatic intracranial hemorrhage post-procedure. The above indexes were compared between the two groups. Results A total of 106 patients were included, with a mean age of 69.6±13.5 years old (range: 24-

90 years old) and 51 males (48.1%), and 46 patients in ADAPT group and 60 patients in stent

group. 43 patients (93.5%) achieved complete recanalization in ADAPT group and 52 patients (86.7%) in stent group. The puncture to recanalization time was shorter in ADAPT group than in stent group [52.5 (31.5-87.7) min vs 64.0 (51.0-98.7) min, P =0.036]; the time of one-time complete recanalization was shorter in ADAPT group than in stent group (37.2±12.4 min vs 59.5±21.4 min, P <0.001). There were no statistical difference in the percentage of one-time and total complete recanalization. The percentage of patients with good prognosis was higher in ADAPT group than in stent group (63.0% vs 36.7%, P =0.007). There was no statistical difference in the incidence of intraoperative thrombus escape and symptomatic intracranial hemorrhage between the two groups. Conclusions Compared to stent-retriever thrombectomy, ADAPT technology for acute intracranial vessel occlusion had a shorter operation time and better clinical efficacy.



Association between Non-high-density Lipoprotein Cholesterol Level and Peripheral Artery Disease

NIU Song-Tao, WANG An-Xin, WU Jian-Wei, WANG Yu, ZHAO Xing-Quan

2021, 16(06):  590-595.  DOI: 10.3969/j.issn.1673-5765.2021.06.011

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Objective To investigate the association between non-high-density lipoprotein cholesterol (non- HDL-C) level and peripheral artery disease (PAD). Methods From June 2010 to June 2011, this study enrolled participants aged ≥40 years and without history of cardiovascular disease in a community-based program. Demographic information, vascular risk factors and laboratory test results were collected. Participants were diagnosed with PAD based on ankle-brachial index (ABI) <0.9. Multivariate logistic regression analysis was used to determine the association between non-HDL-C level and PAD. Results A total of 5132 eligible participants were included, with a mean age of 55.13±11.80 years, 3214 males (60.07%) and a mean non-HDL-C level of 3.42±1.00 mmol/L. Among them, the prevalence of PAD was 3.39% (174/5132). The level of non-HDL-C in participants with PAD was higher than that in those without PAD (3.51±1.03 mmol/L vs 3.42±1.00 mmol/L, P >0.05). Multivariate analysis showed that there was no association of the marginally-elevated (OR 1.23, 95%CI 0.78-1.93, P >0.05) and high non-HDL-C groups (OR 1.24, 95%CI 0.60-2.55, P >0.05) with PAD. Conclusions There was no association between non-HDL-C level and PAD.

Anodic Transcranial Direct Current Stimulation Combined with Donepezil in the Treatment of Post-stroke Cognitive Impairment#br#

WANG Jian-Hui, MA Jing-Li, WANG Yun-Long, LIU Yang, SI Yan-Qin

2021, 16(06):  596-601.  DOI: 10.3969/j.issn.1673-5765.2021.06.013

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Objective To investigate the clinical efficacy of anodic transcranial direct current stimulation (tDCS) combined with donepezil in the treatment of post-stroke cognitive impairment (PSCI). Methods The consecutive PSCI patients admitted in Department of Rehabilitation Medicine, Henan University Affiliated Nanshi Hospital from October 2019 to September 2020 were prospectively enrolled in this study. All the patients were randomly divided into observation group and control group. Both groups were given conventional medications and rehabilitation, on the basis of above treatment, the observation group were added anodic tDCS + donepezil treatment for 4 weeks and the control group was given pseudo-electric stimulation + donepezil treatment for 4 weeks. The cognitive function, memory capacity and the activity of daily life of the patients were evaluated using MoCA, Loewenstein occupational therapy cognitive assessment (LOTCA), Rivermead behavior memory test (RBMT) and modified Barthel index (MBI) before and after the treatment. Results A total of 80 patients were included, including 39 cases in observation group and 41 cases in control group. Before treatment, there was no statistical difference in general information, the

total and item scores of MoCA, LOTCA, RBMT, MBI scores between the two groups. After

treatment, MoCA, LOTCA, RBMT and MBI scores of the observation group were higher than those before treatment, and MoCA, LOTCA and MBI scores of the control group were higher than those before treatment, all the above differences were statistically significant. After treatment, MoCA total score and item score (language, delayed memory, orientation), LOTCA, RBMT, MBI scores of the observation group were all higher than those of the control group, and all the differences were statistically significant. Conclusions tDCS combined with donepezil can effectively improve the cognitive function, memory capacity and activity of daily life of the patients with PSCI in a short time.



Experts Consensus on Post-stroke Respiratory Tract Infection Management

DONG Yi, YE Ting, DONG Qiang

2021, 16(06):  602-610.  DOI: 10.3969/j.issn.1673-5765.2021.06.015

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A Case of Paroxysmal Sympathetic Hyperactivity in Severe Stroke and Literature Review

ZENG Wen-Jing, HUO Kang, CHEN Chen, LIU Fu-De, SONG Wen-Feng, ZHOU Qing-Qing, HAN Jian-Feng, LUO Guo-Gang, QU Qiu-Min

2021, 16(06):  611-615.  DOI: 10.3969/j.issn.1673-5765.2021.06.016

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A Case of Intravenous Thrombolytic Therapy with Alteplase for Acute Ischemic Stroke without Mismatch beyond the Time Window#br#

WANG Lu-Yao, XIONG Yun-Yun, WANG Shang

2021, 16(06):  616-618.  DOI: 10.3969/j.issn.1673-5765.2021.06.017

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Progress of Intracranial In-stent Restenosis

YU Ying, LOU Ya-Ke, CUI Rong-Rong, JIANG Ling-Xian, MA Ning

2021, 16(06):  619-624.  DOI: 10.3969/j.issn.1673-5765.2021.06.018

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In-stent restenosis (ISR) is a major complication of stent implantation for symptomatic intracranial atherosclerotic stenosis (ICAS) or occlusion, which is closely related to long-term recurrent stroke. The pathophysiological mechanism of ISR is still unclear, but it may be related to intimal hyperplasia after arterial injury, and inflammation plays a crucial role in development of ISR. Risk factors for intracranial ISR include lesion location, diabetes, stent diameter, rapid balloon dilatation and long lesion. Currently, target lesion revascularization is the main therapy for intracranial ISR, including simple balloon dilation, metal stent implantation, drugcoated balloon dilation and drug-eluting stent implantation. Drug-coated balloon is expected to be the main measures to prevent intracranial ISR. Preprocedural identification of high-risk ISR can provide a basis for the device selection for endovascular therapy in ICAS patients.

Progress on the Relationship between Albuminuria and Ischemic Stroke

CHEN Shuang-Shuang, ZHOU Yi-Lun

2021, 16(06):  625-630.  DOI: 10.3969/j.issn.1673-5765.2021.06.019

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Ischemic stroke is one of the most leading diseases with high morbidity and disability worldwide. Extra-and-intracranial large artery atherosclerosis is the primary cause of ischemic stroke. Previous studies have suggested that microalbuminuria is not only an important marker of generalized endothelial dysfunction, but also an early marker of atherosclerosis. More recently, many studies have found that albuminuria is closely linked to the pathogenesis, progression and prognosis of ischemic stroke. This article aimed to review the research advances in the relationship between albuminuria and ischemic stroke.

Discussion on the Training Strategy of Young Talents in Neuroscience

ZHAO Tong, KANG Shuai, WANG An-Xin, HUANG Yi-Bing, LYU Shou-Zhu, GAO Xiao-Yan

2021, 16(06):  631-634.  DOI: 10.3969/j.issn.1673-5765.2021.06.020

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Objective To discuss the training strategy of young talents in neuroscience. Methods The young talents who entered into neuroscience related departments from 2015 to 2019 were selected as subjects. The age, gender, work experience, education experience and professional titles and the other related information were collected. The achievements in scientific research (published papers, research projects) were analyzed. Results A total of 75 young talents were included in this analysis, and they were mainly clinical graduates with doctor academic qualification from domestic universities. They published a total of 153 papers after entering the departments, including 98 SCI papers, 10 of which SCI impact factor (IF) ≥5, accounting for 6.5% of all the papers and 10.2% of all the SCI publications. A total of 20 individuals had the approved projects, of whom 9 had primary professional title and 11 had intermediate title. A total of 23 projects were approved, 15 of which were national-level. The multivariate linear regression analysis showed that the number of papers increased with the increase of working years, and the number of SCI publications increased by 0.56 paper per working year (β =0.56, 95%CI 0.03-1.08, P =0.039), physicians with eight-year doctoral degree published 1.54 fewer SCI papers than those with non-eight-year doctoral degree (β =-1.54, 95%CI -3.05-- 0.02, P =0.047); the number of projects of physicians with intermediate professional title increased by 0.55 project (β =0.55, 95%CI 0.18-0.93, P =0.005) compared with those with primary title, but the number of projects decreased by 0.17 project with the increase of working years (β =-0.17, 95%CI -0.31--0.028, P =0.020). Conclusions Young talents in neuroscience in Beijing Tiantan Hospital had strong scientific research foundations and ability, but the proportion of papers with high IF was low. It was necessary to strengthen the utilization of neuroscience resources and research platforms in the hospital for young talents. Compared to young talents with non-eight-year doctoral degree, those with eightyear doctoral degree had relatively weak scientific research foundation. The cultivation of scientific research capability of young talents with eight-year doctoral degree should be strengthened by the tutorial system and systematic training.

Exploring the Efficacy of Training Model of Endovascular Treatment for Acute Ischemic Stroke

LI Xiao-Qing, GAO Yuan, GAO Feng

2021, 16(06):  635-637.  DOI: 10.3969/j.issn.1673-5765.2021.06.021

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Objective To explore the method and mode of training interventional physicians in endovascular treatment of acute ischemic stroke. Methods The trainees of "endovascular treatment training course for acute ischemic stroke" sponsored by International Stroke Intervention Training College of Chinese Stroke Society (CSA) and Beijing Tiantan Hospital of Capital Medical University received theoretical and practical training on endovascular treatment of acute ischemic stroke. The training results were tested through their graduation defense and practical work assessment after completing the whole training program. Results A total of 193 trainees were included in this analysis. They all performed endovascular treatment of acute ischemic stroke for at least one year in clinical practice after completing the whole training program, and then participated in the open graduation defense. The trainees all passed the defense examination and graduated, with the defense passing rate of 100%. Compared to before the training, the median number of surgeries per year performed by the trainees increased by 112%, the median number of surgeries per year performed independently by them increased by 136%, and the incidence of severe complications decreased by 30% (10.2% vs 7.2%) after the standardized training. Conclusions The standardized training of endovascular treatment for acute ischemic stroke combining theoretical training, practical training and personalized training has achieved satisfactory results.