Loading...

Table of Content

    20 September 2008, Volume 3 Issue 09
    主编手记
    Unite to Future
    Yongjun Wang
    2008, 3(09):  623-625. 
    Asbtract ( )   PDF (1914KB) ( )  
    Related Articles | Metrics
    述评
    Integradtion o f Heart and Body
    2008, 3(09):  627-631. 
    Asbtract ( )   PDF (2001KB) ( )  
    Related Articles | Metrics
    论著
    A Study on Association between Serotonin Transporter Gene-linked Polymorphic Region(5-HTTLPR) and the Etiopathogenisis and Therapeutic Effect of Post-stroke Depression and Unipolar Depression
    JIANG Shao-Ai;PAN Xiao-Ping;ZOU Qing;Xu Li-min;Li Ze;Gui Ai-Hua
    2008, 3(09):  642-647. 
    Asbtract ( )   PDF (2552KB) ( )  
    Related Articles | Metrics
    Objective To investigate the possible association of serotonin transporter gene-linked polymorphic region(5-HTTLPR) and the etiopathogenisis as well as therapeutic effect of post-stroke depression(PSD) and unipolar depression(UD) in Chinese Han population.Methods 45 patients with PSD, 41 patients with UD and 149 healthy controls were enrolled in our case-control study. The genotypes and alleles of 5-HTTLPR were detected with PCR. Then the patients with PSD and UD were treated by fluoxetine for 12 weeks. The severity of symptoms and the responses to fluoxetine were rated by the Hamilton Rating Scale for Depression (HAMD-17) on baseline and the 12th weeks.Results There is no significant differences in genotype(S/S, S/L and L/L) and allele(S and L)frequencies of 5-HTTLPR among PSD, unipolar depression and control group. Patieons with S/S genotype had more severe symptoms than those with S/L and L/L. After 12 weeks of treatment,there are significant differences in genotype(S/S, S/L and L/L) and allele(S and L) frequencies of 5-HTTLPR between cured and uncured group.Conclusion 5-HTTLPR may not be associated with PSD and UD in the Chianese Han population.Patient with S/S genotype may be have the more server symptom. After 12 weeks of treatment,patients with S/S genotype and S allele frequency had lower rate of clinical recovery.
    The Effects of Fluoxertin on the Brain-derived Neurotrophic Factor Levels in theHippocampus of the Animal Model of Post-stroke Depression
    2008, 3(09):  648-653. 
    Asbtract ( )   PDF (2665KB) ( )  
    Related Articles | Metrics
    Objective To observe brain-derived neurotrophic factor levels in the hippocampus of the animal model of post-stroke depression.Methods The focal cerebral ischemia model was set up by blocking the middle cerebral artery(MCA), and then the model rats were separately raised and put into chronic unpredictable mild stress to induce the PSD model, part of them were intervened by fluoxertine. The rats were examined dynamically by Open-field test (OFT), sucrose consumption test. Western-blot and Real time-PCRwere used to detect BDNF protein and mRNA levels respectively.Results On the 14th day after CUMS, the PSD group showed significantly less locomotor activity and sugar-water consumption (P <0.05 or P <0.01) compared with the control group. On the 18th ,28th day, BDNF protein levels of the PSD group declined significantly (P <0.05 or P <0.01) compared with the control group. BDNF mRNA levels on the18th day were reduced, but there was no statisticdifference. While on the 28th day, BDNF mRNA levels significantly declined (P <0.01). On the 14th and 18th day, open-field activities and the amount of sugar-water consumption of the fluoxertin intervention group increased markedly (P <0.05 or P <0.01) compared with the PSD group, while onthe 18th and 28th day, BDNF protein and mRNA levels of the fluoxetine group were significantly increased (P <0.01) compared with the PSD group respectively.Conclusion Anhedonia and underactivity, the core symptoms of depression, exist persistently in the PSD group rats. Fluoxetine may can improve the behavior abnormality of the PSD rats. Brain derived neurotrophic factor levels in the animal model of post-stroke depression was significantlyreduced and fluoxetine can reverse its expression levels, BDNF may has neuroprotect effect in poststroke depression.
    Effects of BPI-1095 on Expression of Bcl-2 in Rats after Focal Cerebral Ischemia
    2008, 3(09):  654-657. 
    Asbtract ( )   PDF (2507KB) ( )  
    Related Articles | Metrics
    Objective To investigate the effects of different doses of BPI-1095 on the area of infarction and Bcl-2 protein expression in middle cerebral artery occlusion (MCAO) rats, as well as to explore the protection effects of BPI-1095 on ischemic brain tissue after local cerebral ischemia and its mechanism.Methods Model rats of cerebral ischemia were randomly divided into six groups. Each rat has been given different dosage of medicine and was sacrificed 24 h after treatment. The brain was removed from the skull. Iimmunohistochemistry staining was used to identify Bcl-2 expression in ischemic brain tissue, and the brain tissue was stained by 2% triphenyl-tetrazolium chloride (TTC) to measure the percentage of infarct area.Results 1. The percentage of infarct area was significantly decreased in treated rats with high or moderate dosage compared with the control group (P <0.05); 2. The expression of Bcl-2 protein increased at the boundary and cortex zone of the infarct compared with contralateral hemisphere area.The percentage of positive cells was significantly increased in rats treated with high dosage compared with control or ASA-treated rats. 3. There were no significant differences among three groups of different dosages of BPI-1095.Conclusion BPI-1095 may has a protection effect on brain, especially with high (240 mg/kg) or moderate dosage (80 mg/kg). The mechanism is closely related with the increase of Bcl-2 protein expression.
    Effect of Stent on Evoked Potentials in Patients with Vertebrobasilar Transient Ischemia Attack
    2008, 3(09):  658-661. 
    Asbtract ( )   PDF (2408KB) ( )  
    Related Articles | Metrics
    Objective To evaluate whether stent could improve the recovery of subclinical symptom of patients with vertebrobasilar transient ischemia attack.Methods A series of 11 patients who underwent stenting for vertebrobasilar transient ischemia attack patients with symptomatic vertebrobasilar artery stenosis was investigated in this study. All patients were evaluated with somatosensory evoked potential, brainstem auditory evoked potential, as well as visual evoked potential both before and after stent placement. Latency and wave amplitude of evoked potentials before and after stent placement were analysed for significance.Results We found abnormal evoked potential before the stenting, especially prolonged latency of N20 and P40 in somatosensory evoked potential (SEP), of wave I, III and V in brainstem auditory evoked potential (BAEP), and of P100 in visual evoked potential (VEP). While after the procedure evoked potential showed that in BAEP the latency of I-III wave significantly decreased (P =0.046) and the amplitude of wave III increased significantly (P =0.05); In SEP the latency of N20 was shortened (P =0.012) and the intervals of N13-N20 (P =0.013) and P14-N20 (P =0.005) were both decreased; In VEP the latency of P100 was shortened significantly (P =0.022).Conclusion somatosensory evoked potential, brainstem auditory evoked potential, and visual evoked potential of patients with vertebrobasilar transient ischemia attack were improved after stenting. Stenting is may be helpful to the recovery of subclinical symptom.
    The Effect of Durative-9-hour Hyperbaric Oxygenation Therapy on Cerebral Infarct Volume of Rats in Super-early Stage
    2008, 3(09):  662-666. 
    Asbtract ( )   PDF (3011KB) ( )  
    Related Articles | Metrics
    Objective To assess the effect of durative-9-hour hyperbaric oxygenation (HBO) on cerebral infarct volume in the treatment of rats with permanent middle cerebral artery occlusion (MCAO) in superearly stage.Methods Using the intraluminal suture method, we subjected male Sprague-Dawley rats topermannent MCAO model, then the rats were randomly divided into control group and HBO group.Three hours after MCAO, the rats in the HBO group stayed in the hyperbaric cabin with a pressure of 0.2Mpa for 9 hours. Thirteen hours and 5d after MCAO we calculated the cerebral infarct volume with triphenyltetrazolium chloride(TTC) staining and measured the expression of vascular endothelial growth factor (VEGF) using immunohistochemical staining.Results (1) On 13h, there was no significant difference in the infarct volume between the two groups(P >0.05), and at 5d the volume of control group was larger than that on 13h(P <0.05), while in HBO group the volume was smaller than that in control group (P <0.05). (2) The expression of VEGF increased in both groups on 13h point, and there was no significant difference between the two groups(P >0.05). At 5d after MCAO, the expression of VEGF in control group decreased significantly compared with that on 13h point(P <0.01), but in HBO group the expression of VEGF increased significantly when compared with that on 13h point and that in control group at 5d point(P <0.01).Conclusion Durative-9h HBO protocol in super-early stage can reduce the volume of cerebral infarction in rats. Stimulating more production of endogenous VEGF may be one of the mechanisms.
    The Comparison of the Incidence and the Knowledge about Stroke in Young between Beijing and out of Beijing
    2008, 3(09):  667-671. 
    Asbtract ( )   PDF (2398KB) ( )  
    Related Articles | Metrics
    Objective To find measures to prevent the young stroke through comparison of the incidence and the knowledge about stroke between Beijing and out of Beijing.Methods Total 1214 stroke patients from the 3A grade hospitals of Beijing and 1056 stroke patients from the 3A grade hospitals out of Beijing were recruited. We collected the data including age, sex,habitation, education, occupation, hypertension history, heart diseases history, diabetes history,smoking, drinking alcohol, incidence state, blood lipids, clinical diagnosis and prognosis and so on.Results 1.There were 55 and 83 young patients less than 45-year-old suffered stroke in Beijing and out of Beijing respectively. The young stroke constituent ratio in Beijing was significantly lower than that out of Beijing(4.5%vs7.9%, P <0.05).The constituent ratio in living in urban field, on the job, and male of young stroke were higher in both groups, but there were no significant difference between them(Beijing group was: 60.0%, 65.5%, 81.8%, respectively; Out of Beijing group was:63.8%, 59.0%, 69.9%, respectively, P >0.05). 2. The young stroke subtypes were ischemic stroke,intracerebral hemorrhage (ICH), transient ischemic attack (TIA)in Beijing and ischemic stroke, ICH,subarachnoid hemorrhage(SAH) out of Beijing. 3. The first three risk factors of young stroke were hypertension, smoking, drinking alcohol in both two groups. 4. More than half of the young stroke patients in two groups went to hospital in 1h after onset, but there was no significantly different between them(72.7% vs 56.6%, P >0.05)). The rates of accepting thrombolysis, beyond the time of thrombolysis and knowing as a high risk individual were no significant difference between Beijing group and out of Beijing group (9.1% vs 4.8%, P >0.05; 29.1%vs 31.3%16.9%, P >0.05; 29.1%vs16.9%, P >0.05, respectively). The death rate were 3.6% and 1.2% in Beijing and out of Beijing respectively.Conclusion 1.The higher constituent ratio is happened in male, living urban field and on the job of young stroke in two groups. 2.Hypertension, smoking and drinking are the important risk factors in both two groups. 3.The young stroke subtypes are ischemic stroke and intracerebral hemorrhage in two groups. 4.The lower death rate happens in young stroke patients in Beijing and out of Beijing.5.The young patients with stroke in two groups know a few of knowledge about stroke.
    综述
    The Role of the Non-language-based Depression Scale in Indentifying Depression ofStroke Survivors with Aphasia
    2008, 3(09):  704-708. 
    Asbtract ( )   PDF (2011KB) ( )  
    Related Articles | Metrics
    One third stroke survivors have aphasia which seriously affects their work, study, daily life and social activities. Therefore, patients with aphasia are more susceptive to have depression. Traditional depression identifying methods are language-based and often ignore the depression of patients with post-stroke aphasia, they are not suitable for identifying the depression of patients with aphasia. In order to solve this problem, scholars have developed a number of nonlanguage-dependent depression rating scales. This review is to emonstrate the application of the non-language-based depression screening tools.