关键词: 缺血性卒中; 动脉硬化性狭窄; 代谢综合征

Abstract:

Objective To investigate the relationship between intracranial atherosclerotic Stenosis and metabolic syndrome at different blood glucose levels in patients with acute ischemic stroke (AIS). Methods A total of 352 AIS patients who were treated in Dept. of Neurology of our hospital between June 2013 and June 2016 were selected as the study group, and were divided into stenosis group (n =227) and non-stenosis group (n =125), according to the degrees of intracranial vascular stenosis. A total of 310 subjects with non-intracranial atherosclerotic stenosis who visited our hospital for medical examination in the same period were selected as the control group. Patients with metabolic syndrome in the study group were divided into 3 subgroups: normal glucose tolerance group, diabetic group, and hyperglycemia group (including impaired fasting glucose and impaired glucose tolerance). The levels of blood lipid in metabolic syndrome patients were measured, and the correlation between metabolic syndrome at different blood glucose levels and intracranial atherosclerotic stenosis was analyzed. Results Among 352 AIS patients, 195 cases were diagnosed as metabolic syndrome. The incidence of metabolic syndrome in the study group was significantly higher than that in the control group, which had significantly difference (P <0.05). The incidence of metabolic syndrome in the stenosis group was significantly higher than that in the non-stenosis group, which had significant difference (P <0.05). The proportion of metabolic syndrome patients with diabetes in the stenosis group was significantly higher than that in the non-stenosis group and control group, which had significant difference (P <0.05). There was no significant difference in the proportion of metabolic syndrome patients with hyperglycemia and impaired glucose tolerance in the stenosis group and non-stenosis group (P >0.05). Logistic regression analysis showed that there was a significant correlation between metabolic syndrome and intracranial atherosclerotic stenosis; and there was significant positive correlation between metabolic syndrome with diabetes, with low high density lipoprotein (HDL), high triglyceride (TG) and intracranial atherosclerotic stenosis risk. Conclusion Among AIS patients, the metabolic syndrome with diabetes, high blood TG, low HDL levels was closely associated with intracranial atherosclerosis stenosis.

Key words: Ischemic stroke; Atherosclerotic stenosis; Metabolic syndrome