缺血性卒中患者颈动脉斑块与内皮素-1及丙二醛水平的相关性分析

doi:10.3969/j.issn.1673-5765.2018.09.009

摘要/Abstract

摘要：

目的探讨急性缺血性卒中患者颈动脉粥样硬化斑块与血浆内皮素-1（endothelin-1，ET-1）及丙二醛（malondialdehyde，MDA）水平的关系。

方法 118例急性缺血性卒中患者均行颈动脉超声检查，分为动脉内膜正常组（12例）、动脉内膜增厚组（28例）及动脉斑块组（78例）；并将斑块组分为I级斑块（21例）、II级斑块（25例）、III级斑块（32例）。测定各组患者血浆ET-1及MDA水平，并进行统计分析。

结果内膜正常组、内膜增厚组和斑块组血浆ET-1水平分别为（2.34±0.27）ng/L、（3.96±0.38）ng/L和（6.23±0.42）ng/L；MDA水平分别为（4.20±0.48）nmol/ml、（6.18±0.52）nmol/ml和（8.37±0.65）nmol/ml。斑块组及内膜增厚组患者血浆ET-1（P =0.036，P =0.031）及MDA（P =0.046，P =0.022）水平均高于内膜正常组，差异有统计学意义；斑块组血浆ET-1（P =0.040）及MDA（P =0.034）水平高于内膜增厚组，差异有统计学意义。斑块组血浆ET-1（P =0.041）及MDA（P =0.037）水平随着斑块的严重程度而增加。

结论血浆ET-1及MDA水平与急性缺血性卒中患者颈动脉粥样硬化及其严重程度有关。

文章导读： 本研究对缺血性卒中患者颈动脉粥样硬化斑块的存在及严重程度与血浆内皮素-1及丙二醛的关系进行了分析，结果显示随着动脉斑块的出现及发展，内皮素-1及丙二醛的水平有显著增高的趋势。

关键词: 缺血性卒中; 颈动脉斑块; 内皮素-1; 丙二醛

Abstract:

Objective To investigate the correlation between carotid plaques and endothelin-1 (ET-1) and malondialdehyde (MDA) in patients with acute ischemic stroke. Methods Carotid ultrasonography was performed in 118 patients with acute ischemic stroke. All patients were divided into normal intima group (n =12), intima thickening group (n =28) and plaque group (n =78). The plaque group was divided into plaque I (n =21), plaque II (n =25) and plaque III (n =32). The plasma ET-1 and MDA level were measured in each group. The correlation of ET-1 and MDA with plaque formation was analyzed. Results The level of plasma ET-1 in normal, thickening intima and plaque groups were (2.34±0.27) ng/L, (3.96±0.38) ng/L and (6.23±0.42) ng/L, respectively; and the level of plasma MDA in the three groups were (4.20±0.48) nmol/ml, (6.18±0.52) nmol/ml and (8.37±0.65) nmol/ml, respectively. The level of plasma ET-1 (P =0.036, P =0.031) and MDA (P =0.046, P =0.022) in plaque group and intima thickening group were significantly higher than that in normal intima group; and both ET-1 and MDA in plaque group were higher than that in intima thickening group (P =0.040, P =0.034). With the severity of plaque increasing, the plasma ET-1 and MDA levels gradually increased (P =0.041, P =0.037). Conclusion Plasma ET-1 and MDA levels are associated with carotid atherosclerosis and its severity in patients with acute ischemic stroke.

Key words: Ischemic stroke; Carotid plaque; Endothelin-1; Malondialdehyde

温慧军, 吕敏. 缺血性卒中患者颈动脉斑块与内皮素-1及丙二醛水平的相关性分析[J]. 中国卒中杂志, 2018, 13(09): 934-937.

WEN Hui-Jun, LYU Min. Correlation of Endothelin-1 and Malondialdehyde with Carotid Plaques in Patients with Ischemic Stroke[J]. Chinese Journal of Stroke, 2018, 13(09): 934-937.

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