脑皮质表面铁沉积研究进展

doi:10.3969/j.issn.1673-5765.2020.03.018

摘要/Abstract

摘要：

脑皮质表面铁沉积（cortical superficial siderosis，cSS）是近年来发现的含铁复合物在脑皮质表面形成的线样沉积物。cSS主要存在于淀粉样脑血管病和阿尔茨海默病患者中。其典型临床表现为短暂性局灶性神经样发作和认知功能障碍。MRI T2 *加权梯度回波序列和SWI序列检测到cSS为沿大脑沟回表面分布的线样低信号，分为局灶性cSS和播散性cSS。cSS可预测淀粉样脑血管病患者未来颅内出血风险并且与不良功能结局预后及认知功能障碍相关，有望指导临床抗血栓等治疗决策。

文章导读： 脑皮质表面铁沉积和淀粉样脑血管病患者颅内出血相关，对其综合评估有助于对此类患者未来颅内出血风险分层和预后判断。

关键词: 脑皮质表面铁沉积; 淀粉样脑血管病; 阿尔茨海默病; 认知功能障碍; 颅内出血

Abstract:

Cortical superficial siderosis (cSS) is linear residents of chronic blood products in the superficial layers of cerebral cortex. cSS is mainly found in patients with cerebral amyloid angiopathy (CAA) and Alzheimer’s disease. The typical clinical manifestations of patients with cSS are transient focal neurological episodes and cognitive impairment. The imaging features of cSS shows a characteristic “gyriform” pattern of low signal on MRI T2 *-weighted gradient recalled echo (T2 *-GRE) and susceptibility weighted imaging, and the distribution of cSS was classified as focal and disseminated cSS. cSS can be used to predict the risk of intracerebral haemorrhage in patients with CAA and it is associated with poor functional outcome and cognitive impairment. Therefore, cSS may have a clinical value in guidance for clinical treatment decision-makings such as antithrombotic treatment.

Key words: Cortical superficial siderosis; Cerebral amyloid angiopathy; Alzheimer’s disease;Intracerebral haemorrhage; Cognitive impairment

李梦，李国忠，钟镝. 脑皮质表面铁沉积研究进展[J]. 中国卒中杂志, 2020, 15(03): 320-325.

LI Meng, LI Guo-Zhong, ZHONG Di. Progress in Research on Cortical Superficial Siderosis[J]. Chinese Journal of Stroke, 2020, 15(03): 320-325.

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