关键词: 脑出血; 消化道出血; 血管危险因素; 影响因素

Abstract: Objective To analyze the risk factors of gastrointestinal bleeding (GB) secondary to acute cerebral hemorrhage. Methods Patients with acute cerebral hemorrhage admitted to the Department of Neurology, Beijing Tiantan Hospital, Capital Medical University from may to December, 2017 were enrolled in this retrospective analysis. The clinical data, including the demographics information, vascular risk factors, medication history, comorbid diseases, physical examination and laboratory tests, time of onset, bleeding site, bleeding volume, were collected. According to having in-hospital GB or not, the patients were divided into GB group and no-GB group. A multivariate logistic regression model was used to analyze the independent risk factors for GB secondary to acute cerebral hemorrhage. Results A total of 314 patients were included, 16 (5.09%) of whom had secondary GB during hospitalization. Univariate analysis showed that the proportion of alcohol consumption, the NIHSS score and systolic blood pressure and blood glucose level at admission were all higher and the bleeding volume was larger in GB group than that in no-GB group. Multivariate analysis showed that history of coronary heart disease (OR 6.63, 95%CI 1.36-32.34, P =0.019), drinking (OR 6.61, 95%CI 1.45-30.22, P =0.015), high admission NIHSS score (OR 1.15, 95%CI 1.07-1.24, P <0.001)

and high admission systolic blood pressure (OR 1.03, 95%CI 1.00-1.05, P =0.021) were independent

risk factors for in-hospital GB secondary to acute cerebral hemorrhage. Conclusions Patients with acute cerebral hemorrhage with high systolic blood pressure, high NIHSS score, history of drinking, and history of coronary heart disease at admission are at higher risk of gastrointestinal hemorrhage during hospitalization.

Key words: Cerebral hemorrhage; Gastrointestinal hemorrhage; Vascular risk factor; Risk factor