头晕/眩晕患者脑小血管病总负荷的危险因素分析

doi:10.3969/j.issn.1673-5765.2022.04.006

摘要/Abstract

摘要：

目的探讨头晕/眩晕患者脑小血管病（cerebral small vessel disease，CSVD）总负荷的危险因素。

方法回顾性分析2021年5-12月首都医科大学附属北京朝阳医院神经内科连续收治住院的头晕/眩晕患者。所有患者住院期间进行常规实验室检查、前庭功能相关检查（包括变位试验）和头颅MRI 检查。对入组患者进行最终病因诊断和CSVD总负荷评分记录。比较不同CSVD负荷评分组（0分、1分、 2分、3分和4分组）的临床资料特点，采用logistic回归模型分析头晕/眩晕患者CSVD总负荷评分的独立危险因素。

结果本研究共纳入头晕/眩晕患者210例，平均年龄66.9±10.7岁，男性患者101例（48.1%）。CSVD 总负荷0分组81例（38.6%），1分组78例（37.1%），2分组23例（11.0%），3分组19例（9.0%），4分组9例（4.3%）。单因素分析结果显示不同CSVD总负荷评分组年龄、高血压、糖尿病、缺血性卒中病史、吸烟、糖化血红蛋白和Hcy水平差异有统计学意义。logistic回归分析显示吸烟（OR 2.386， 95%CI 1.232～4.623，P =0.010）和高血压（OR 1.979，95%CI 1.084～3.612，P =0.026）是头晕/眩晕患者CSVD总负荷评分升高的独立危险因素。

结论吸烟和高血压是头晕/眩晕患者CSVD负荷升高的独立危险因素。

文章导读： 本研究利用头颅MRI对头晕/眩晕患者进行CSVD负荷分层并对其危险因素进行了多因素分析，结果显示吸烟和高血压对CSVD负荷有独立影响。

关键词: 头晕; 眩晕; 脑小血管病; 总负荷评分; 危险因素; 吸烟; 高血压

Abstract: Objective To explore the risk factors for the total cerebral small vessel disease (CSVD) burden in patients with dizziness or vertigo. Methods This retrospective study enrolled consecutive patients with dizziness or vertigo who were admitted in Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University from May 2021 to December 2021. All patients completed routine laboratory examination, vestibular function examinations (including Dix-hallpike test or roll test) and brain MRI. The final diagnosis and total CSVD burden score were recorded. The clinical data of patients in different load score groups (0, 1, 2, 3 and 4 score groups) were compared. Logistic regression model was used to identify the related risk factors of total CSVD burden in patients with dizziness or vertigo. Results A total of 210 eligible patients were included, with an average age of 66.9±10.7 years and 101 males (48.1%). Finally, there were 81 cases (38.6%) in 0 score group, 78 cases (37.1%) in 1 score group, 23 cases (11.0%) in 2 score group, 19 cases (9.0%) in 3 score group and 9 cases (4.3%) in 4 score group. Univariate analysis showed that there were statistical differences in age, hypertension, diabetes, history of ischemic stroke, smoking, glycosylated hemoglobin and the level of Hcy in different CSVD burden score groups. Logistic regression analysis showed that the smoking (OR 2.386, 95%CI 1.232-4.623, P =0.010) and hypertension (OR 1.979, 95%CI 1.084-3.612,

P =0.026) were independent risk factors of total CSVD burden in patients with dizziness or vertigo.

Conclusions Smoking and hypertension were independent risk factors for the total CSVD burden in patients with dizziness or vertigo.

Key words: Dizziness; Vertigo; Cerebral small vessel disease; Total burden score; Risk factor;Smoking; Hypertension

朱翠婷, 胡文立. 头晕/眩晕患者脑小血管病总负荷的危险因素分析[J]. 中国卒中杂志, 2022, 17(04): 354-359.

ZHU Cuiting, HU Wenli. Analysis on Risk Factors for Total Cerebral Small Vessel Disease Burden in Patients with Dizziness or Vertigo[J]. Chinese Journal of Stroke, 2022, 17(04): 354-359.

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