关键词: 阿司匹林抵抗; 心血管疾病; 血小板聚集; 血栓素A2

Abstract: Aspirin resistance has two definitions. Clinical aspirin resistance is defined aspatients taking aspirin unable free from ischemic cardiovascular events. This definition ignores thecomplexity of pathogenesis of cardiovascular diseases. Furthermore, it is not realistic to expectthat all vascular complications can be prevented by single preventive strategy. Biochemical aspirinresistance means aspirin cannot produce an anticipated effect on one or more laboratory testsof platelet function when taking aspirin, such as inhibiting platelet aggregation or biosynthesisof thromboxane. However, the methodologies of these tests have not yet been standardized. Theresults of these experiments are lacking in specificity, sensitivity and reproducibility. The clinicalrelevance has not been established. Therefore, at present, aspirin resistance is only an idea withoutclinical significance.

Key words: Aspirin resistance; Cardiovascular disease; Platelet aggregation; Thromboxane A2