关键词: 超声检查; 多普勒; 彩色; 血流剪切力; 颈动脉狭窄

Abstract: Objective To evaluate wall shear stress in both sides of asymmetrical carotid atherosclerosis patients, and analyze the relationship between wall shear stress and carotid atherosclerosis.Methods 78 participants screened by doppler ultrasound examination who presented unilateralplaque were enrolled. Internal diameter(ID), peak systolic velocity(Vp), and intima-media thickness (IMT) of common carotid were measured by doppler ultrasound independently.. Evaluate the difference of τ m and IMT between the carotids with and without atherosclerotic lesions,andanalyze the relationship between τ m and IMT by linear correlation analysis.Results ID is larger in the side with atherosclerotic lesions than in the side without lesions(6.7±0.9mm vs 6.1±0.8mm, P <0.01). IMT is thicker in the side with atherosclerotic lesions than in the side without lesions(1.3±0.2mm vs 0.8±0.1mm, P <0.01). τ m is lower in the side with atherosclerotic lesions than in the side without lesions(18±5 dynes·cm-2 vs 23±9 dynes·cm-2,P <0.01.) IMT is negatively correlated with τm.Conclusion In asymmetrical carotid atherosclerosis, wall shear stress is different between the different sides, which is lower in the carotid arteries where plaques are present than in plaque-free arteries obviously. The wall shear stress is negatively correlated with IMT. These findings providein vivo evidence for a association between wall shear stress and atherosclerotic lesions.

Key words: Ultrasonography; doppler; color; Atherosclerosis wall shear stress; Cartoid stemosis